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Details on Person UniProt:P61158 ACTR3

Class:Id	ReferenceGeneProduct:50303
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-418 added on Fri February 6 2015;initiator methionine:1 for 50303 removed on Fri Nov 03 2023;initiator methionine: for 50303 added on Fri Nov 03 2023;initiator methionine: for 50303 removed on Fri Aug 15 2025;initiator methionine:1 for 50303 added on Fri Aug 15 2025
_displayName	UniProt:P61158 ACTR3
_timestamp	2025-08-15 21:36:12
chain	initiator methionine:1 chain:2-418
checksum	23E5564198B81C63
comment	FUNCTION ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563).SUBUNIT Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (PubMed:11741539, PubMed:9000076, PubMed:9230079). Interacts with WHDC1 (PubMed:18614018). Interacts weakly with MEFV (PubMed:19109554). Interacts with AVIL (PubMed:29058690).INTERACTION In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).SIMILARITY Belongs to the actin family. ARP3 subfamily.ONLINE INFORMATION On mar and motion - Issue 208 of November 2018
description	recommendedName: Actin-related protein 3 alternativeName: Actin-like protein 3
geneName	ACTR3 ARP3
identifier	P61158
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Actin-binding ATP-binding Cell projection Cilium biogenesis/degradation Cytoplasm Cytoskeleton Direct protein sequencing Nucleotide-binding Nucleus Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	ACTR3
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8958520] ENSEMBL:ENSG00000115091 ACTR3 [Homo sapiens]
secondaryIdentifier	ARP3_HUMAN P32391 Q53QM2
sequenceLength	418
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:200811] ACTR3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202989] ACTR3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8958109] ACTR3 [extracellular region] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P61158 ACTR3 (50303)