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Details on Person UniProt:P27540 ARNT
| Class:Id | ReferenceGeneProduct:50297 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-789 added on Fri February 6 2015;initiator methionine:1 for 50297 removed on Fri Nov 03 2023;initiator methionine: for 50297 added on Fri Nov 03 2023;initiator methionine: for 50297 removed on Fri Aug 15 2025;initiator methionine:1 for 50297 added on Fri Aug 15 2025 |
| _displayName | UniProt:P27540 ARNT |
| _timestamp | 2025-08-15 21:43:28 |
| chain | initiator methionine:1 chain:2-789 |
| checksum | 2E278F8E62BFBF6D |
| comment | FUNCTION Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).SUBUNIT Monomer. Homodimer only upon binding to a DNA (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with TACC3 (By similarity). Interacts with HIF1A, EPAS1, NPAS1 and NPAS3; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity) (PubMed:16181639, PubMed:20699359). Forms a heterodimer with AHRR, as well as with other bHLH proteins (Probable). Interacts with NOCA7 (PubMed:10395741). Interacts with TACC3 (By similarity). Interacts with AHR; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409, PubMed:34521881). Interacts with SIM1 and NPAS4 (By similarity).INTERACTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: fullName evidence="16"Aryl hydrocarbon receptor nuclear translocator shortName: ARNT protein alternativeName: Class E basic helix-loop-helix protein 2 shortName: bHLHe2 alternativeName: Dioxin receptor, nuclear translocator alternativeName: Hypoxia-inducible factor 1-beta shortName: HIF-1-beta shortName: HIF1-beta |
| geneName | ARNT BHLHE2 |
| identifier | P27540 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Alternative splicing Direct protein sequencing DNA-binding Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ARNT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001611] ENSEMBL:ENSG00000143437 ARNT [Homo sapiens] |
| secondaryIdentifier | ARNT_HUMAN B2R9H1 C4AMA1 F8WAP6 Q59ED4 Q5QP39 Q8NDC7 |
| sequenceLength | 789 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144194] UniProt:P27540-2 ARNT [Homo sapiens] [ReferenceIsoform:394530] UniProt:P27540-3 ARNT [Homo sapiens] [ReferenceIsoform:403495] UniProt:P27540-1 ARNT [Homo sapiens] [ReferenceIsoform:8969090] UniProt:P27540-4 ARNT [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:1234098] ARNT [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8936836] ARNT [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8962617] ARNT [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P27540 ARNT (50297)
