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Details on Person UniProt:P56559 ARL4C
| Class:Id | ReferenceGeneProduct:50287 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-192 added on Sat February 7 2015;initiator methionine:1 for 50287 removed on Fri Nov 03 2023;initiator methionine: for 50287 added on Fri Nov 03 2023;initiator methionine: for 50287 removed on Fri Aug 15 2025;initiator methionine:1 for 50287 added on Fri Aug 15 2025 |
| _displayName | UniProt:P56559 ARL4C |
| _timestamp | 2025-08-15 21:20:57 |
| chain | initiator methionine:1 chain:2-192 |
| checksum | 389BD49CF9E6D10D |
| comment | FUNCTION Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.SUBUNIT Interacts with CYTH2. Interacts with alpha tubulin; interaction is independent on the ARL4C GTP or GDP binding status.SUBCELLULAR LOCATION Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.INDUCTION By liver X-receptor/retinoid X receptor agonists or cholesterol loading.SIMILARITY Belongs to the small GTPase superfamily. Arf family.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: ADP-ribosylation factor-like protein 4C alternativeName: ADP-ribosylation factor-like protein 7 alternativeName: ADP-ribosylation factor-like protein LAK |
| geneName | ARL4C ARL7 |
| identifier | P56559 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Cell projection Cytoplasm GTP-binding Lipoprotein Membrane Myristate Nucleotide-binding Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ARL4C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993469] ENSEMBL:ENSG00000188042 ARL4C [Homo sapiens] |
| secondaryIdentifier | ARL4C_HUMAN Q4A519 Q53R10 Q9BVN1 Q9UQ34 |
| sequenceLength | 192 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969086] UniProt:P56559-1 ARL4C [Homo sapiens] [ReferenceIsoform:8969087] UniProt:P56559-2 ARL4C [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9618406] ARL4C [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P56559 ARL4C (50287)
