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Details on Person UniProt:P25098 GRK2
| Class:Id | ReferenceGeneProduct:50271 |
|---|---|
| _chainChangeLog | chain:1-689 added on Fri February 6 2015 |
| _displayName | UniProt:P25098 GRK2 |
| _timestamp | 2026-02-20 21:46:52 |
| chain | chain:1-689 |
| checksum | 4DB68F62841AFA7D |
| comment | FUNCTION Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses (By similarity). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:21799898, PubMed:23077507). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927).CATALYTIC ACTIVITY [beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+)ACTIVITY REGULATION In contrast to other AGC family kinases, the catalytic activity is solely regulated by the binding of substrates and ligands, not by phosphorylation of the kinase domain.SUBUNIT Interacts with the heterodimer formed by GNB1 and GNG2 (By similarity). Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5 (PubMed:10085131). Interacts with ARRB1 (PubMed:9501202). Interacts with LPAR1 and LPAR2 (PubMed:19306925). Interacts with RALA in response to LPAR1 activation (PubMed:19306925). ADRBK1 and RALA mutually inhibit each other's binding to LPAR1 (PubMed:19306925). Interacts with ADRB2 (PubMed:19715378).INTERACTION Expressed in peripheral blood leukocytes.DOMAIN The PH domain binds anionic phospholipids and helps recruiting ADRBK1 from the cytoplasm to plasma membrane close to activated receptors. It mediates binding to G protein beta and gamma subunits, competing with G-alpha subunits and other G-betagamma effectors.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.ONLINE INFORMATION Beta adrenergic receptor kinase entry |
| description | recommendedName: Beta-adrenergic receptor kinase 1 shortName: Beta-ARK-1 ecNumber evidence="12"2.7.11.15 alternativeName: fullName evidence="18"G-protein coupled receptor kinase 2 |
| geneName | GRK2 ADRBK1 BARK BARK1 |
| identifier | P25098 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cell membrane Cell projection Cytoplasm Kinase Membrane Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Synapse Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GRK2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998168] ENSEMBL:ENSG00000173020 GRK2 [Homo sapiens] |
| secondaryIdentifier | ARBK1_HUMAN B0ZBE1 Q13837 Q6GTT3 |
| sequenceLength | 689 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:50270] GRK2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:111969] p-S29-ADRBK1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5632504] ADRBK1 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9645318] p-S29-ADRBK1 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:111968] O-phospho-L-serine at 29 |
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No pathways have been reviewed or authored by UniProt:P25098 GRK2 (50271)
