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Details on Person UniProt:Q9NP61 ARFGAP3
| Class:Id | ReferenceGeneProduct:50255 |
|---|---|
| _chainChangeLog | chain:1-516 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NP61 ARFGAP3 |
| _timestamp | 2024-11-03 19:55:11 |
| chain | chain:1-516 |
| checksum | E355E56A5D867F8E |
| comment | FUNCTION GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.ACTIVITY REGULATION GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).INTERACTION Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.ALTERNATIVE PRODUCTS Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary.DEVELOPMENTAL STAGE Expressed at higher level in adult thymus, brain and lung, than in corresponding fetal tissues. Expressed at lower level in spleen, heart, kidney and liver during development.CAUTION Was originally termed ARFGAP1.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: ADP-ribosylation factor GTPase-activating protein 3 shortName: ARF GAP 3 |
| geneName | ARFGAP3 ARFGAP1 |
| identifier | Q9NP61 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Coiled coil Cytoplasm ER-Golgi transport Golgi apparatus GTPase activation Membrane Metal-binding Phosphoprotein Protein transport Proteomics identification Reference proteome Transport Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ARFGAP3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962319] ENSEMBL:ENSG00000242247 ARFGAP3 [Homo sapiens] |
| secondaryIdentifier | ARFG3_HUMAN E9PB03 Q9BSC6 Q9H9J0 Q9NT10 Q9NUP5 Q9Y4V3 Q9Y4V4 |
| sequenceLength | 516 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8972286] UniProt:Q9NP61-1 ARFGAP3 [Homo sapiens] [ReferenceIsoform:8972287] UniProt:Q9NP61-2 ARFGAP3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5216040] ARFGAP3 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:6807740] ARFGAP3 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NP61 ARFGAP3 (50255)
