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Details on Person UniProt:Q8N6T3 ARFGAP1
| Class:Id | ReferenceGeneProduct:50251 |
|---|---|
| _chainChangeLog | chain:1-406 added on Sat February 7 2015 |
| _displayName | UniProt:Q8N6T3 ARFGAP1 |
| _timestamp | 2024-11-03 19:55:11 |
| chain | chain:1-406 |
| checksum | CAE41828DE660621 |
| comment | FUNCTION GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).SUBUNIT Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. The interaction with TMED2 inhibits the GAP activity (By similarity).INTERACTION Associates with the Golgi complex.ALTERNATIVE PRODUCTS The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity).SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Intron retention. |
| description | recommendedName: ADP-ribosylation factor GTPase-activating protein 1 shortName: ARF GAP 1 alternativeName: ADP-ribosylation factor 1 GTPase-activating protein shortName: ARF1 GAP alternativeName: ARF1-directed GTPase-activating protein |
| geneName | ARFGAP1 ARF1GAP |
| identifier | Q8N6T3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm ER-Golgi transport Golgi apparatus GTPase activation Metal-binding Phosphoprotein Protein transport Proteomics identification Reference proteome Transport Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ARFGAP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5642275] ENSEMBL:ENSG00000101199 ARFGAP1 [Homo sapiens] |
| secondaryIdentifier | ARFG1_HUMAN B7Z3U0 B7Z8H8 B7ZBI3 E1P5I9 E7EV62 Q6PK71 Q96KC4 Q96T02 Q9NSU3 Q9NVF6 Q9UIL0 |
| sequenceLength | 406 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144144] UniProt:Q8N6T3-2 ARFGAP1 [Homo sapiens] [ReferenceIsoform:219002] UniProt:Q8N6T3-3 ARFGAP1 [Homo sapiens] [ReferenceIsoform:411338] UniProt:Q8N6T3-1 ARFGAP1 [Homo sapiens] [ReferenceIsoform:8970389] UniProt:Q8N6T3-4 ARFGAP1 [Homo sapiens] [ReferenceIsoform:8970390] UniProt:Q8N6T3-5 ARFGAP1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:200464] ARFGAP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:201333] ARFGAP1 [Golgi-associated vesicle membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8N6T3 ARFGAP1 (50251)
