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Details on Person UniProt:O15145 ARPC3
| Class:Id | ReferenceGeneProduct:50206 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-178 added on Fri February 6 2015;initiator methionine:1 for 50206 removed on Fri Nov 03 2023;initiator methionine: for 50206 added on Fri Nov 03 2023;initiator methionine: for 50206 removed on Fri Aug 15 2025;initiator methionine:1 for 50206 added on Fri Aug 15 2025 |
| _displayName | UniProt:O15145 ARPC3 |
| _timestamp | 2025-08-15 21:51:09 |
| chain | initiator methionine:1 chain:2-178 |
| checksum | 7149F598B48F0EAC |
| comment | FUNCTION Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).SUBUNIT Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.INTERACTION Belongs to the ARPC3 family. |
| description | recommendedName: Actin-related protein 2/3 complex subunit 3 alternativeName: Arp2/3 complex 21 kDa subunit shortName: p21-ARC |
| geneName | ARPC3 ARC21 |
| identifier | O15145 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ARPC3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001612] ENSEMBL:ENSG00000111229 ARPC3 [Homo sapiens] |
| secondaryIdentifier | ARPC3_HUMAN O00554 |
| sequenceLength | 178 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:200812] ARPC3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202997] ARPC3 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O15145 ARPC3 (50206)
