Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:O15511 ARPC5

Class:Id	ReferenceGeneProduct:50196
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-151 added on Fri February 6 2015;initiator methionine:1 for 50196 removed on Fri Nov 03 2023;initiator methionine: for 50196 added on Fri Nov 03 2023;initiator methionine: for 50196 removed on Fri Aug 15 2025;initiator methionine:1 for 50196 added on Fri Aug 15 2025
_displayName	UniProt:O15511 ARPC5
_timestamp	2026-02-20 21:27:33
chain	initiator methionine:1 chain:2-151
checksum	F050B11774EA6E66
comment	FUNCTION Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).SUBUNIT Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.INTERACTION Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ARPC5 family.
description	recommendedName: Actin-related protein 2/3 complex subunit 5 alternativeName: Arp2/3 complex 16 kDa subunit shortName: p16-ARC
geneName	ARPC5 ARC16
identifier	O15511
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Actin-binding Alternative splicing Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Nucleus Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	ARPC5
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8960236] ENSEMBL:ENSG00000162704 ARPC5 [Homo sapiens]
secondaryIdentifier	ARPC5_HUMAN A6NEC4 Q6PG42
sequenceLength	151
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:219252] UniProt:O15511-2 ARPC5 [Homo sapiens] [ReferenceIsoform:401350] UniProt:O15511-1 ARPC5 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:200806] ARPC5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202995] ARPC5 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6801065] ARPC5 [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801071] ARPC5 [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801548] ARPC5 [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:6806476] ARPC5 [extracellular region] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:O15511 ARPC5 (50196)