Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P07741 APRT
| Class:Id | ReferenceGeneProduct:50172 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-180 added on Fri February 6 2015;initiator methionine:1 for 50172 removed on Fri Nov 03 2023;initiator methionine: for 50172 added on Fri Nov 03 2023;initiator methionine: for 50172 removed on Fri Aug 15 2025;initiator methionine:1 for 50172 added on Fri Aug 15 2025 |
| _displayName | UniProt:P07741 APRT |
| _timestamp | 2025-08-15 21:20:53 |
| chain | initiator methionine:1 chain:2-180 |
| checksum | CDC7703337A6E453 |
| comment | FUNCTION Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.CATALYTIC ACTIVITY AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenineBIOPHYSICOCHEMICAL PROPERTIES Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.SUBUNIT Homodimer.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the purine/pyrimidine phosphoribosyltransferase family.ONLINE INFORMATION Adenine phosphoribosyltransferase entry |
| description | recommendedName: fullName evidence="14"Adenine phosphoribosyltransferase shortName: APRT ecNumber evidence="4"2.4.2.7 |
| geneName | APRT |
| identifier | P07741 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant Glycosyltransferase Phosphoprotein Proteomics identification Purine salvage Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | APRT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994664] ENSEMBL:ENSG00000198931 APRT [Homo sapiens] |
| secondaryIdentifier | APT_HUMAN G5E9J2 Q3KP55 Q68DF9 |
| sequenceLength | 180 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8970387] UniProt:P07741-1 APRT [Homo sapiens] [ReferenceIsoform:8970388] UniProt:P07741-2 APRT [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:50171] APRT [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6801079] APRT [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801581] APRT [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801587] APRT [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:6806528] APRT [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9734183] APRT D65V [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9734184] APRT M136T [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9734191] APRT L110P [cytosol] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:9734187] L-methionine 136 replaced with L-threonine [ReplacedResidue:9734188] L-aspartic acid 65 replaced with L-valine [ReplacedResidue:9734189] L-leucine 110 replaced with L-proline |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P07741 APRT (50172)
