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Details on Person UniProt:P08519 LPA
| Class:Id | ReferenceGeneProduct:50156 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Fri February 6 2015;chain:20-4548 added on Fri February 6 2015;chain:20-4548 for 50156 removed on Wed May 4 2022;chain:20-2040 for 50156 added on Wed May 4 2022 |
| _displayName | UniProt:P08519 LPA |
| _timestamp | 2024-11-03 20:13:15 |
| chain | signal peptide:1-19 chain:20-2040 |
| checksum | AC7D76CE0A0358CD |
| comment | FUNCTION Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.SUBUNIT Disulfide-linked to apo-B100. Binds to fibronectin and decorin.INTERACTION N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected.POLYMORPHISM LPA genetic variants, including variations in the number of Kringle domains, define the lipoprotein(a) quantitative trait locus (LPAQTL) and influence lipoprotein(a) levels in plasma [MIM:618807]. Depending on the individual, the encoded protein contains 2-43 copies of kringle IV-2 repeats. Often the assignement of amino acids in lipoprotein(a) is based on a long allele that contains 37 copies of the kringle-type repeats (PubMed:3670400). The reference allele represented here contains 15 copies of the kringle-type repeats.MISCELLANEOUS Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.SIMILARITY Belongs to the peptidase S1 family. Plasminogen subfamily. |
| description | recommendedName: Apolipoprotein(a) shortName: Apo(a) shortName: Lp(a) ecNumber: 3.4.21.- |
| geneName | LPA |
| identifier | P08519 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Atherosclerosis Autocatalytic cleavage Disulfide bond Glycoprotein Hydrolase Kringle Lipid transport Protease Proteomics identification Reference proteome Repeat Serine protease Signal Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LPA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998739] ENSEMBL:ENSG00000198670 LPA [Homo sapiens] |
| secondaryIdentifier | APOA_HUMAN Q5VTD7 Q9UD88 |
| sequenceLength | 2040 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:176877] LPA [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P08519 LPA (50156)
