Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q9H1Y0 ATG5

Class:Id	ReferenceGeneProduct:50130
_chainChangeLog	chain:1-275 added on Fri February 6 2015
_displayName	UniProt:Q9H1Y0 ATG5
_timestamp	2025-08-15 21:58:57
chain	chain:1-275
checksum	C33A1E0B3C1DBE5C
comment	FUNCTION Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. As part of the ATG8 conjugation system with ATG12 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity).FUNCTION May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.FUNCTION (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601).SUBUNIT Forms a conjugate with ATG12 (PubMed:11825910, PubMed:12207896, PubMed:17709747, PubMed:26812546). Part of the minor complex composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa); this complex interacts with ATG3 leading to disruption of ATG7 interaction and promotion of ATG8-like proteins lipidation (PubMed:24191030). Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (By similarity). The ATG12-ATG5 conjugate interacts with RAB33A; this interaction is bridged by ATG16L1 and promotes ATG12-ATG5-ATG16L1 complex recruitment to phagophores (PubMed:32960676). Interacts with TECPR1; the interaction is direct and does not take place when ATG16L1 is associated with the ATG5-ATG12 conjugate (PubMed:21575909, PubMed:22342342). Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate form. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Interacts with ATG3 (PubMed:11825910, PubMed:12207896). Interacts with ATG7 and ATG10 (By similarity). Interacts with FADD (PubMed:15778222). Interacts with Bassoon/BSN; this interaction is important for the regulation of presynaptic autophagy (By similarity). Interacts with ATG16L2 (By similarity).SUBUNIT (Microbial infection) Interacts transiently interacts with hepatitis C virus (HCV) protein NS5B during HCV infection.SUBUNIT (Microbial infection) Interacts with S.flexneri IcsA; bacterial IcsB inhibits this interaction.INTERACTION Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. Under starved conditions, the ATG12-ATG5-ATG16L1 complex is translocated to phagophores driven by RAB33B (PubMed:32960676).ALTERNATIVE PRODUCTS Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.INDUCTION By apoptotic stimuli.PTM Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.PTM Acetylated by EP300.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ATG5 family.
description	recommendedName: fullName evidence="21"Autophagy protein 5 alternativeName: APG5-like alternativeName: Apoptosis-specific protein
geneName	ATG5 APG5L ASP
identifier	Q9H1Y0
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Apoptosis Autophagy Cytoplasm Disease variant Host-virus interaction Immunity Isopeptide bond Membrane Neurodegeneration Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	ATG5
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8999922] ENSEMBL:ENSG00000057663 ATG5 [Homo sapiens]
secondaryIdentifier	ATG5_HUMAN O60875 Q5JVR2 Q68DI4 Q9H2B8 Q9HCZ7
sequenceLength	275
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:144081] UniProt:Q9H1Y0-2 ATG5 [Homo sapiens] [ReferenceIsoform:414177] UniProt:Q9H1Y0-1 ATG5 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:936010] ATG5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5205636] ATG5 [phagocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:5683582] GlyK130-ATG5 [cytosol] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:5683568] N6-glycyl-L-lysine at 130
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q9H1Y0 ATG5 (50130)