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Details on Person APEX1 [nucleoplasm]

Class:Id	EntityWithAccessionedSequence:50119
_displayName	APEX1 [nucleoplasm]
_timestamp	2014-11-11 18:52:55
compartment	[Compartment:7660] nucleoplasm
endCoordinate	318
modified	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00 [InstanceEdit:110406] Matthews, L, 2004-04-02 03:43:20 [InstanceEdit:111433] Matthews, L, 2004-02-14 01:20:00 [InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08 [InstanceEdit:141731] Matthews, L, 2004-10-03 14:13:00 [InstanceEdit:3632907] Wu, G, 2013-05-28 [InstanceEdit:5637644] Orlic-Milacic, Marija, 2014-11-11
name	APEX1 APE1 DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein) DNA-(apurinic or apyrimidinic site) lyase AP endonuclease 1 APEX nuclease APEN REF-1 protein HAP1
referenceEntity	[ReferenceGeneProduct:50120] UniProt:P27695 APEX1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:365039] R-HSA-50119.1
startCoordinate	2
(activeUnit)	[CatalystActivity:5649547] DNA endonuclease activity of APEX1:AP-dsDNA [nucleoplasm]
(hasComponent)	[Complex:110332] APEX1:AP-dsDNA [nucleoplasm] [Homo sapiens] [Complex:110334] APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] [Homo sapiens] [Complex:110347] DNA containing unligated replacement-synthesized patch [nucleoplasm] [Homo sapiens] [Complex:110348] LIG1:APEX1 [nucleoplasm] [Homo sapiens] [Complex:110407] APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Homo sapiens] [Complex:110408] APE1:FEN1 complex [nucleoplasm] [Homo sapiens] [Complex:111434] Ligated patch-repaired DNA [nucleoplasm] [Homo sapiens] [Complex:5649859] APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] [Homo sapiens] [Complex:5649885] POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] [Homo sapiens] [Complex:5651804] APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] [Homo sapiens] List all 12 refering instances
(input)	[Reaction:110349] Displacement of UNG glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110350] Displacement of TDG glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110351] Displacement of SMUG1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110353] Displacement of MBD4 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110354] Displacement of OGG1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110355] Displacement of MUTYH glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:110356] Displacement of MPG glycosylase by APEX1 at the AP site [Homo sapiens]
(output)	[Reaction:110375] Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break [Homo sapiens] [Reaction:5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site [Homo sapiens] [Reaction:5651809] LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA [Homo sapiens]
(physicalEntity)	[CatalystActivity:110358] DNA endonuclease activity of APEX1 [nucleoplasm]
(regulator)	[PositiveGeneExpressionRegulation:9965266] Positive gene expression regulation by 'APEX1 [nucleoplasm]'
(updatedInstance)	[_UpdateTracker:9883294] Update Tracker - [EntityWithAccessionedSequence:50119] APEX1 [nucleoplasm] - v45:[addName]
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No pathways have been reviewed or authored by APEX1 [nucleoplasm] (50119)