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Details on Person UniProt:Q99767 APBA2
Class:Id
ReferenceGeneProduct:50104
_chainChangeLog
chain:1-749 added on Fri February 6 2015
_displayName
UniProt:Q99767 APBA2
_timestamp
2024-11-03 19:49:55
chain
chain:1-749
checksum
C15AE9CFAEF51D85
comment
FUNCTION Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.SUBUNIT Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid-beta protein, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of NECAB3.INTERACTION Brain.DOMAIN Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
description
recommendedName: Amyloid-beta A4 precursor protein-binding family A member 2 alternativeName: Adapter protein X11beta alternativeName: Neuron-specific X11L protein alternativeName: Neuronal Munc18-1-interacting protein 2 shortName: Mint-2
geneName
APBA2 MINT2 X11L
identifier
Q99767
isSequenceChanged
FALSE
keyword
Alternative splicing Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Transport
