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Details on Person UniProt:Q92481 TFAP2B
| Class:Id | ReferenceGeneProduct:50086 |
|---|---|
| _chainChangeLog | chain:1-460 added on Sat February 7 2015 |
| _displayName | UniProt:Q92481 TFAP2B |
| _timestamp | 2024-11-03 19:39:58 |
| chain | chain:1-460 |
| checksum | A6420EA0C265DDA2 |
| comment | FUNCTION Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.SUBUNIT Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity.INTERACTION In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum.ALTERNATIVE PRODUCTS Sumoylated on Lys-21; which inhibits transcriptional activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the AP-2 family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION Activating protein 2 entry |
| description | recommendedName: Transcription factor AP-2-beta shortName: AP2-beta alternativeName: Activating enhancer-binding protein 2-beta |
| geneName | TFAP2B |
| identifier | Q92481 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Disease variant DNA-binding Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TFAP2B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993462] ENSEMBL:ENSG00000008196 TFAP2B [Homo sapiens] |
| secondaryIdentifier | AP2B_HUMAN Q5JYX6 Q9NQ63 Q9NU99 Q9UJI7 Q9Y214 Q9Y3K3 |
| sequenceLength | 460 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144066] UniProt:Q92481-2 TFAP2B [Homo sapiens] [ReferenceIsoform:412415] UniProt:Q92481-1 TFAP2B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:3234060] TFAP2B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3234107] monoSUMO1-K21-TFAP2B [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:3234065] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 21 |
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No pathways have been reviewed or authored by UniProt:Q92481 TFAP2B (50086)
