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Details on Person Diagram of Phase II - Conjugation of compounds, Defective AHCY causes HMAHCHD, Defective GCLC causes HAGGSD, Defective GGT1 causes GLUTH, Defective GSS causes GSS deficiency, Defective MAT1A causes MATD, Defective OPLAH causes OPLAHD, Defective SLC35D1 causes SCHBCKD, and Defective TPMT causes TPMT deficiency
| Class:Id | PathwayDiagram:500771 |
|---|---|
| _displayName | Diagram of Phase II - Conjugation of compounds, Defective AHCY causes HMAHCHD, Defective GCLC causes HAGGSD, Defective GGT1 causes GLUTH, Defective GSS causes GSS deficiency, Defective MAT1A causes MATD, Defective OPLAH causes OPLAHD, Defective SLC35D1 causes SCHBCKD, and Defective TPMT causes TPMT deficiency |
| _timestamp | 2026-02-25 10:59:50 |
| created | [InstanceEdit:500770] Jassal, B, 2010-02-05 |
| height | 2000 |
| modified | [InstanceEdit:1679954] Wu, G, 2011-10-20 [InstanceEdit:1791258] Jassal, B, 2011-10-21 [InstanceEdit:1918100] Rothfels, K, 2011-11-02 [InstanceEdit:1920013] Rothfels, K, 2011-11-02 [InstanceEdit:2121206] Matthews, L, 2012-02-13 [InstanceEdit:2193078] Wu, G, 2012-04-11 [InstanceEdit:2603292] D'Eustachio, P, 2012-11-19 [InstanceEdit:3037589] Jassal, B, 2013-02-06 [InstanceEdit:3302058] Jassal, B, 2013-04-23 [InstanceEdit:3341401] D'Eustachio, P, 2013-05-11 [InstanceEdit:3343792] Jassal, B, 2013-05-13 [InstanceEdit:3499327] Jassal, B, 2013-05-17 [InstanceEdit:3548370] Jassal, B, 2013-05-20 [InstanceEdit:3903040] Jassal, B, 2013-07-17 [InstanceEdit:3907286] Gillespie, ME, 2013-07-18 [InstanceEdit:3968343] Gillespie, ME, 2013-07-23 [InstanceEdit:5580284] Jassal, Bijay, 2014-06-10 [InstanceEdit:5601814] Jassal, Bijay, 2014-06-13 [InstanceEdit:5607772] Jassal, Bijay, 2014-07-14 [InstanceEdit:5621775] Jassal, Bijay, 2014-09-05 [InstanceEdit:5622089] Jassal, Bijay, 2014-09-10 [InstanceEdit:5634114] Jassal, Bijay, 2014-11-03 [InstanceEdit:6782073] Jassal, Bijay, 2015-06-04 [InstanceEdit:6782074] Jassal, Bijay, 2015-06-04 [InstanceEdit:6783231] Jassal, Bijay, 2015-06-11 [InstanceEdit:6783355] Jassal, Bijay, 2015-06-12 [InstanceEdit:6784311] Jassal, Bijay, 2015-06-19 [InstanceEdit:6784313] Jassal, Bijay, 2015-06-19 [InstanceEdit:6785944] Jassal, Bijay, 2015-07-02 [InstanceEdit:6797421] Jassal, Bijay, 2015-09-11 [InstanceEdit:6814690] Jassal, Bijay, 2015-11-27 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8942721] D'Eustachio, Peter, 2016-10-19 [InstanceEdit:8942722] D'Eustachio, Peter, 2016-10-19 [InstanceEdit:8942990] D'Eustachio, Peter, 2016-10-21 [InstanceEdit:8943287] D'Eustachio, Peter, 2016-10-24 [InstanceEdit:8943475] Jassal, Bijay, 2016-10-25 [InstanceEdit:8943476] Jassal, Bijay, 2016-10-25 [InstanceEdit:8943477] Jassal, Bijay, 2016-10-25 [InstanceEdit:8954003] Jassal, Bijay, 2017-01-04 [InstanceEdit:8954015] Jassal, Bijay, 2017-01-04 [InstanceEdit:8954165] Jassal, Bijay, 2017-01-05 [InstanceEdit:8954298] Jassal, Bijay, 2017-01-06 [InstanceEdit:8954306] Jassal, Bijay, 2017-01-06 [InstanceEdit:8959737] Jassal, Bijay, 2017-01-30 [InstanceEdit:8959981] Jassal, Bijay, 2017-02-01 [InstanceEdit:8959995] Jassal, Bijay, 2017-02-01 [InstanceEdit:9632042] Jassal, Bijay, 2018-12-13 [InstanceEdit:9632049] Jassal, Bijay, 2018-12-13 [InstanceEdit:9638051] Jassal, Bijay, 2019-02-25 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9697719] Jassal, Bijay, 2020-08-20 [InstanceEdit:9704993] Jassal, Bijay, 2020-10-19 [InstanceEdit:9704995] Jassal, Bijay, 2020-10-19 [InstanceEdit:9704999] Jassal, Bijay, 2020-10-19 [InstanceEdit:9713162] Jassal, Bijay, 2021-01-21 [InstanceEdit:9716766] D'Eustachio, Peter, 2021-02-24 [InstanceEdit:9774475] D'Eustachio, Peter, 2022-05-23 [InstanceEdit:9838651] D'Eustachio, Peter, 2023-06-23 [InstanceEdit:9912893] D'Eustachio, Peter, 2024-06-10 [InstanceEdit:9942392] Stephan, Ralf, 2025-03-16 [InstanceEdit:9948478] Stephan, Ralf, 2025-05-21 [InstanceEdit:9953025] Stephan, Ralf, 2025-05-28 [InstanceEdit:9953026] Stephan, Ralf, 2025-05-28 [InstanceEdit:9954140] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9968098] D'Eustachio, Peter, 2025-10-09 [InstanceEdit:9968099] D'Eustachio, Peter, 2025-10-09 [InstanceEdit:9968113] D'Eustachio, Peter, 2025-10-09 [InstanceEdit:9971072] Stephan, Ralf, 2025-11-04 [InstanceEdit:9971730] D'Eustachio, Peter, 2025-11-10 [InstanceEdit:9983647] Stephan, Ralf, 2026-02-25 |
| representedPathway | [Pathway:156580] Phase II - Conjugation of compounds [Homo sapiens] [Pathway:5578997] Defective AHCY causes HMAHCHD [Homo sapiens] [Pathway:5578999] Defective GCLC causes HAGGSD [Homo sapiens] [Pathway:5579022] Defective GGT1 causes GLUTH [Homo sapiens] [Pathway:5579006] Defective GSS causes GSS deficiency [Homo sapiens] [Pathway:5579024] Defective MAT1A causes MATD [Homo sapiens] [Pathway:5578998] Defective OPLAH causes OPLAHD [Homo sapiens] [Pathway:5579020] Defective SLC35D1 causes SCHBCKD [Homo sapiens] [Pathway:5578995] Defective TPMT causes TPMT deficiency [Homo sapiens] |
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position="890 1543" bounds="859 1528 62 31" textPosition="864 1532"> <Properties> <displayName>formate</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1117" reactomeId="5693717" position="1000 1465" bounds="966 1454 69 23" textPosition="968 1455" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ESD dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1119" reactomeId="174404" position="3660 292" bounds="3602 277 116 31" textPosition="3612 281"> <Properties> <displayName>5-methyl-THFPG</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1120" reactomeId="197969" position="3628 440" bounds="3600 425 56 31" textPosition="3605 429"> <Properties> <displayName>THFPG</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1170" reactomeId="5696216" position="4054 1018" bounds="4011 1003 86 31" textPosition="4019 1007"> <Properties> <displayName>arsenite(3-)</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1171" reactomeId="5696214" position="4263 1016" bounds="4211 1001 105 31" textPosition="4216 1005"> <Properties> <displayName>methylarsonate</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1172" reactomeId="5696206" position="4159 1004" bounds="4135 993 49 23" textPosition="4135 993" /> <org.gk.render.RenderableChemical id="1174" reactomeId="71284" position="4056 1085" bounds="4026 1070 61 31" textPosition="4031 1074"> <Properties> <displayName>AdoMet</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1176" reactomeId="71285" position="4234 1090" bounds="4204 1075 61 31" textPosition="4209 1079" /> <org.gk.render.RenderableChemical id="1178" reactomeId="5696224" position="4540 1014" bounds="4490 999 101 31" textPosition="4495 1003"> <Properties> <displayName>methylarsonite</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1179" reactomeId="5696211" position="4542 1193" bounds="4486 1178 112 31" textPosition="4492 1182"> <Properties> <displayName>dimethylarsinate</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1493" reactomeId="111745" position="4471 976" bounds="4448 961 47 31" textPosition="4452 965"> <Properties> <displayName>GSSG</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1494" reactomeId="29356" position="4467 1055" bounds="4446 1040 43 31" textPosition="4451 1044" /> <org.gk.render.RenderableComplex id="1495" reactomeId="198825" position="4407 946" bounds="4364 935 87 23" textPosition="4366 936" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GSTO1 dimer</displayName> </Properties> 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<Properties> <displayName>APAP</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableChemical id="1707" reactomeId="70106" position="583 180" bounds="569 169 28 23" textPosition="571 169" /> <org.gk.render.RenderableCompartment id="1708" reactomeId="17963" position="363 491" bounds="239 310 248 363" textPosition="253 617" bgColor="250 240 240" lineColor="255 153 102" insets="248 319 230 354"> <Components> <Component id="1715" /> <Component id="1719" /> <Component id="1717" /> <Component id="1721" /> <Component id="1729" /> <Component id="1730" /> <Component id="1731" /> <Component id="1732" /> <Component id="1733" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="1717" reactomeId="1889970" position="380 571" bounds="343 556 74 31" textPosition="350 560" /> <org.gk.render.RenderableChemical id="1718" reactomeId="109402" position="536 645" bounds="515 630 42 31" textPosition="519 634" /> <org.gk.render.RenderableProtein id="1719" reactomeId="744235" position="482 527" bounds="451 516 62 23" textPosition="453 516"> <Properties> <displayName>SLC35D2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1721" reactomeId="735698" position="423 632" bounds="402 617 42 31" textPosition="406 621"> <Properties> <displayName>UMP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1730" reactomeId="425969" position="314 543" bounds="296 528 36 31" textPosition="302 532" /> <org.gk.render.RenderableChemical id="1731" reactomeId="742361" position="377 381" bounds="345 366 65 31" textPosition="352 370"> <Properties> <displayName>UDP-Xyl</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1732" reactomeId="8863760" position="316 422" bounds="295 407 42 31" textPosition="300 411"> <Properties> <displayName>CO2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1733" reactomeId="9912900" position="484 478" bounds="449 460 70 36" textPosition="457 460" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>UXS1 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1734" reactomeId="174362" position="2561 135" bounds="2490 103 142 65" textPosition="2497 113"> <Properties> <displayName>Transport and metabolism of PAPS</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemical id="1737" reactomeId="193132" position="1256 388" bounds="1225 373 62 31" textPosition="1230 377"> <Properties> <displayName>EST17b</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1745" reactomeId="9971077" position="2953 1308" bounds="2901 1293 104 31" textPosition="2905 1297"> <Properties> <displayName>phenylacetyl-Gly</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="1747" reactomeId="3968340" position="2819 1204" bounds="2757 1193 125 23" textPosition="2762 1193"> <Properties> <displayName>GLYAT-like proteins</displayName> </Properties> <Shortcuts> <Shortcut id="1747" /> <Shortcut id="1762" /> </Shortcuts> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="1751" reactomeId="159549" position="2678 1242" bounds="2661 1227 35 31" textPosition="2666 1231"> <Properties> <displayName>Gly</displayName> </Properties> <Shortcuts> <Shortcut id="1751" /> <Shortcut id="1764" /> </Shortcuts> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1753" reactomeId="29374" position="2960 1259" bounds="2929 1244 62 31" textPosition="2935 1248" /> <org.gk.render.RenderableChemical id="1755" reactomeId="113529" position="2929 1224" bounds="2913 1209 33 31" textPosition="2917 1213" /> <org.gk.render.RenderableChemical id="1759" reactomeId="9972915" position="2936 1546" bounds="2895 1531 83 31" textPosition="2899 1535" /> <org.gk.render.RenderableChemical id="1760" reactomeId="9972914" position="2644 1575" bounds="2619 1560 50 31" textPosition="2623 1564" /> <org.gk.render.RenderableEntitySet id="1762" reactomeId="3968340" position="2796 1644" bounds="2734 1633 125 23" textPosition="2739 1633" /> <org.gk.render.RenderableChemical id="1764" reactomeId="159549" position="2903 1598" bounds="2886 1583 35 31" textPosition="2891 1587" /> <org.gk.render.RenderableChemical id="1766" reactomeId="113529" position="2695 1617" bounds="2679 1602 33 31" textPosition="2683 1606" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="9" reactomeId="174916" points="717 909, 717 946, 717 992" position="717 946" lineWidth="1.0"> <Inputs> <Input id="6" points="744 884" /> <Input id="23" points="644 844" /> </Inputs> <Outputs> <Output id="5" points="661 1040" /> <Output id="7" points="747 1026" /> </Outputs> <Catalysts> <Catalyst id="4" points="958 879, 770 945" /> </Catalysts> <Properties> <displayName>Formation of N-glucuronides</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10" reactomeId="174931" points="571 903, 571 948, 571 987" position="571 948" lineWidth="1.0"> <Inputs> <Input id="2" points="536 876" /> <Input id="23" points="616 844" /> </Inputs> <Outputs> <Output id="3" points="526 1024" /> <Output id="5" points="628 1040" /> </Outputs> <Catalysts> <Catalyst id="8" points="519 948" /> </Catalysts> <Properties> <displayName>UGTs transfer GlcA from UDP-GlcA to O-centre substrates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="174368" points="598 701, 598 741, 599 775" position="598 741" lineWidth="1.0"> <Inputs> <Input id="737" points="648 683" /> <Input id="18" points="625 647" /> </Inputs> <Outputs> <Output id="23" points="619 807" /> <Output id="725" points="664 785" /> </Outputs> <Catalysts> <Catalyst id="12" points="648 741" /> </Catalysts> <Properties> <displayName>SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="25" reactomeId="70286" points="630 204, 631 252, 631 292" position="631 252" lineWidth="1.0"> <Inputs> <Input id="13" points="654 193" /> <Input id="20" points="630 170" /> <Input id="1707" points="600 187" /> </Inputs> <Outputs> <Output id="21" points="683 306" /> <Output id="14" points="631 336" /> </Outputs> <Catalysts> <Catalyst id="17" points="662 252" /> </Catalysts> <Properties> <displayName>UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="26" reactomeId="173597" points="634 434, 634 490, 635 552" position="634 490" lineWidth="1.0"> <Inputs> <Input id="16" points="618 420" /> <Input id="11" stoichiometry="2" points="659 420" /> <Input id="14" points="632 375" /> </Inputs> <Outputs> <Output id="18" points="633 610" /> <Output id="19" stoichiometry="2" points="666 570" /> <Output id="15" stoichiometry="3" points="597 570" /> </Outputs> <Catalysts> <Catalyst id="22" points="601 489" /> </Catalysts> <Properties> <displayName>UDP-glucose is oxidised to UDP-glucuronate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="75" reactomeId="176494" points="1745 471, 1745 504, 1745 536" position="1745 504" lineWidth="1.0"> <Inputs> <Input id="53" points="1728 389" /> <Input id="55" points="2296 173, 1827 339" /> </Inputs> <Outputs> <Output id="32" points="1745 675" /> <Output id="64" points="2299 927, 1825 695" /> </Outputs> <Catalysts> <Catalyst id="50" points="1710 502" /> </Catalysts> <Properties> <displayName>SULTs transfer (SO4)2- group to 27HCHOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="76" reactomeId="176669" points="1919 469, 1919 502, 1919 534" position="1919 502" lineWidth="1.0"> <Inputs> <Input id="66" points="1906 410" /> <Input id="55" points="2296 179, 1998 362" /> </Inputs> <Outputs> <Output id="52" points="1919 654" /> <Output id="64" points="2299 922, 1998 697" /> </Outputs> <Catalysts> <Catalyst id="29" points="1884 503" /> </Catalysts> <Properties> <displayName>N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="77" reactomeId="176517" points="1574 476, 1573 498, 1573 560" position="1573 498" lineWidth="1.0"> <Inputs> <Input id="481" points="1576 399" /> <Input id="55" points="2296 172, 1642 354" /> </Inputs> <Outputs> <Output id="45" points="1572 634" /> <Output id="64" points="2299 930, 1678 721" /> </Outputs> <Catalysts> <Catalyst id="44" points="1541 495" /> </Catalysts> <Properties> <displayName>SULTs transfer (SO4)2- group to PREG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="78" reactomeId="176646" points="3372 388, 3372 449, 3372 518, 3372 587" position="3372 518" lineWidth="1.0"> <Inputs> <Input id="55" points="2347 170" /> <Input id="1097" points="3444 353" /> </Inputs> <Outputs> <Output id="31" points="3405 650" /> <Output id="64" points="2344 932, 3289 689" /> </Outputs> <Catalysts> <Catalyst id="46" points="3402 515" /> </Catalysts> <Properties> <displayName>p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="79" reactomeId="158860" points="3217 469, 3217 502, 3217 534" position="3217 502" lineWidth="1.0"> <Inputs> <Input id="54" points="3224 418" /> <Input id="55" points="2347 171, 3137 369" /> </Inputs> <Outputs> <Output id="36" points="3217 629" /> <Output id="64" points="2344 930, 3131 683" /> </Outputs> <Catalysts> <Catalyst id="67" points="3148 492" /> </Catalysts> <Properties> <displayName>SULT1A1 dimer sulfonates NHABP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="80" reactomeId="176664" points="1416 457, 1416 500, 1416 540" position="1416 500" lineWidth="1.0"> <Inputs> <Input id="55" points="2296 171, 1477 357" /> <Input id="35" points="1418 408" /> </Inputs> <Outputs> <Output id="39" points="1414 613" /> <Output id="64" points="2299 931, 1529 711" /> </Outputs> <Catalysts> <Catalyst id="70" points="1377 498" /> </Catalysts> <Properties> <displayName>estrone + PAPS => estrone 3-sulfate + PAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="81" reactomeId="176474" points="2390 473, 2390 506, 2390 538" position="2390 506" lineWidth="1.0"> <Inputs> <Input id="59" points="2428 396" /> <Input id="55" points="2324 185" /> </Inputs> <Outputs> <Output id="49" points="2436 630" /> <Output id="64" points="2323 919" /> </Outputs> <Catalysts> <Catalyst id="60" points="2434 503" /> </Catalysts> <Properties> <displayName>3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="82" reactomeId="176521" points="1256 457, 1256 496, 1256 541" position="1256 496" lineWidth="1.0"> <Inputs> <Input id="1737" points="1256 407" /> <Input id="55" points="2296 170, 1355 363" /> </Inputs> <Outputs> <Output id="56" points="1256 594" /> <Output id="64" points="2299 931, 1341 667" /> </Outputs> <Catalysts> <Catalyst id="33" points="1232 495" /> </Catalysts> <Properties> <displayName>beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="83" reactomeId="176609" points="871 461, 871 494, 871 526" position="871 494" lineWidth="1.0"> <Inputs> <Input id="68" points="871 381" /> <Input id="55" points="2296 169, 927 357" /> </Inputs> <Outputs> <Output id="48" points="821 560" /> <Output id="64" points="2299 932, 871 613" /> </Outputs> <Catalysts> <Catalyst id="38" points="844 494" /> </Catalysts> <Properties> <displayName>cholesterol + PAPS => cholesterol sulfate + PAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="84" reactomeId="176604" points="1111 468, 1111 501, 1111 533" position="1111 501" lineWidth="1.0"> <Inputs> <Input id="55" points="2296 169, 1210 360" /> <Input id="34" points="1111 410" /> </Inputs> <Outputs> <Output id="71" points="1111 582" /> <Output id="64" points="2299 932, 1234 672" /> </Outputs> <Catalysts> <Catalyst id="62" points="1086 498" /> </Catalysts> <Properties> <displayName>taurolithocholate + PAPS => taurolithocholate sulfate + PAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="85" reactomeId="176588" points="949 478, 949 495, 949 511" position="949 495" lineWidth="1.0"> <Inputs> <Input id="41" points="949 420" /> <Input id="55" points="2296 169, 1017 357" /> </Inputs> <Outputs> <Output id="69" points="941 576" /> <Output id="64" points="2299 932, 1053 643" /> </Outputs> <Catalysts> <Catalyst id="62" points="981 494" /> </Catalysts> <Properties> <displayName>lithocholate + PAPS => lithocholate sulfate + PAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="86" reactomeId="176631" points="2107 481, 2106 505, 2107 521" position="2106 505" lineWidth="1.0"> <Inputs> <Input id="65" points="2112 399" /> <Input id="55" points="2310 185" /> </Inputs> <Outputs> <Output id="57" points="2102 654" /> <Output id="64" points="2313 919" /> </Outputs> <Catalysts> <Catalyst id="47" points="2066 503" /> </Catalysts> <Properties> <displayName>dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="87" reactomeId="158849" points="2842 431, 2842 501, 2842 539" position="2842 501" lineWidth="1.0"> <Inputs> <Input id="28" points="2841 385" /> <Input id="55" points="2347 177" /> </Inputs> <Outputs> <Output id="40" points="2842 624" /> <Output id="64" points="2341 919" /> </Outputs> <Catalysts> <Catalyst id="67" points="3043 488" /> </Catalysts> <Properties> <displayName>Phenol can form a sulfate conjugate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="159358" points="2633 483, 2633 507, 2633 531" position="2633 507" lineWidth="1.0"> <Inputs> <Input id="30" points="2634 421" /> <Input id="55" points="2336 185" /> </Inputs> <Outputs> <Output id="72" points="2624 625" /> <Output id="64" points="2332 919" /> </Outputs> <Catalysts> <Catalyst id="1625" points="2660 506" /> </Catalysts> <Properties> <displayName>SULT1A3,4 dimers sulfate DA to DAOS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="176585" points="2321 479, 2321 503, 2321 527" position="2321 503" lineWidth="1.0"> <Inputs> <Input id="58" points="2258 408" /> <Input id="55" points="2321 185" /> </Inputs> <Outputs> <Output id="63" points="2268 608" /> <Output id="64" points="2321 919" /> </Outputs> <Catalysts> <Catalyst id="37" points="2283 503" /> </Catalysts> <Properties> <displayName>3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="90" reactomeId="158468" points="3018 453, 3021 542, 3021 574" position="3021 542" lineWidth="1.0"> <Inputs> <Input id="1703" points="3018 417" /> <Input id="55" points="2347 173, 2886 347" /> </Inputs> <Outputs> <Output id="73" points="3016 646" /> <Output id="64" points="2344 928, 2933 684" /> </Outputs> <Catalysts> <Catalyst id="67" points="3079 501" /> </Catalysts> <Properties> <displayName>SULT1A1 dimer sulfonates PARA to PARA-SO4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="101" reactomeId="174959" points="1388 846, 1387 943, 1388 1042" position="1387 943" lineWidth="1.0"> <Inputs> <Input id="96" points="1416 794" /> <Input id="94" points="1360 847" /> </Inputs> <Outputs> <Output id="98" points="1416 1064" /> <Output id="93" points="1297 1044" /> </Outputs> <Catalysts> <Catalyst id="94" points="1338 863, 1356 943" /> </Catalysts> <Properties> <displayName>The acetyl group from acetyl-CoA is transferred to NAT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="102" reactomeId="174967" points="1693 1039, 1603 931, 1603 847" position="1603 931" lineWidth="1.0"> <Inputs> <Input id="97" points="1648 1040" /> <Input id="99" points="1731 1039" /> </Inputs> <Outputs> <Output id="91" points="1636 846" /> <Output id="95" points="1554 846" /> </Outputs> <Catalysts> <Catalyst id="97" points="1608 1027" /> </Catalysts> <Properties> <displayName>NAT2 acetylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="103" reactomeId="158832" points="1468 845, 1468 940, 1468 1039" position="1468 940" lineWidth="1.0"> <Inputs> <Input id="96" points="1434 794" /> <Input id="95" points="1506 845" /> </Inputs> <Outputs> <Output id="97" points="1571 1040" /> <Output id="98" points="1446 1064" /> </Outputs> <Catalysts> <Catalyst id="95" points="1526 861, 1498 940" /> </Catalysts> <Properties> <displayName>The acetyl group from acetyl-CoA is transferred to NAT2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="104" reactomeId="174963" points="1167 1041, 1250 929, 1250 847" position="1250 929" lineWidth="1.0"> <Inputs> <Input id="92" points="1129 1041" /> <Input id="93" points="1220 1043" /> </Inputs> <Outputs> <Output id="94" points="1312 847" /> <Output id="100" points="1189 844" /> </Outputs> <Catalysts> <Catalyst id="93" points="1257 1031" /> </Catalysts> <Properties> <displayName>NAT1 acetylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="131" reactomeId="175983" points="4431 603, 4431 697, 4351 821" position="4431 697" lineWidth="1.0"> <Inputs> <Input id="108" points="4427 557" /> <Input id="130" points="4180 418, 4272 452" /> </Inputs> <Outputs> <Output id="124" points="4295 848" /> <Output id="111" points="4084 825" /> </Outputs> <Catalysts> <Catalyst id="129" points="4455 697" /> </Catalysts> <Properties> <displayName>COMT transfer CH3 from AdoMet to 3,4DHBNZ</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="132" reactomeId="174391" points="4142 218, 4144 284, 4146 334" position="4144 284" lineWidth="1.0"> <Inputs> <Input id="112" points="4176 209" /> <Input id="110" points="4113 210" /> <Input id="119" points="4138 146" /> </Inputs> <Outputs> <Output id="123" points="4206 357" /> <Output id="116" points="4112 351" /> <Output id="130" points="4146 390" /> </Outputs> <Catalysts> <Catalyst id="121" points="4170 284" /> </Catalysts> <Properties> <displayName>MAT1A multimers transfer Ado from ATP to L-Met</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="133" reactomeId="174374" points="3738 590, 3738 486, 3809 422" position="3738 486" lineWidth="1.0"> <Inputs> <Input id="118" points="3738 696" /> <Input id="501" points="3653 502" /> </Inputs> <Outputs> <Output id="119" points="4120 146" /> <Output id="742" points="3810 373" /> </Outputs> <Catalysts> <Catalyst id="501" points="3703 486" /> </Catalysts> <Properties> <displayName>MTR transfers CH3 from MeCbl to HCYS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="134" reactomeId="158609" points="4149 598, 4149 681, 4175 724" position="4149 681" lineWidth="1.0"> <Inputs> <Input id="107" points="4205 577" /> <Input id="130" points="4146 427" /> </Inputs> <Outputs> <Output id="111" points="4068 808" /> <Output id="114" points="4194 768" /> <Output id="365" points="4216 728" /> </Outputs> <Catalysts> <Catalyst id="115" points="4228 677" /> </Catalysts> <Properties> <displayName>TPMT transfers CH3 from AdoMet to 6MP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="135" reactomeId="174401" points="3884 825, 3831 825, 3737 825" position="3831 825" lineWidth="1.0"> <Inputs> <Input id="111" points="4017 825" /> <Input id="138" points="3913 849" /> </Inputs> <Outputs> <Output id="122" points="3684 825" /> <Output id="118" points="3737 733" /> </Outputs> <Catalysts> <Catalyst id="125" points="3831 792" /> </Catalysts> <Properties> <displayName>AHCY:NAD+ tetramer hydrolyses AdoHcy</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="136" reactomeId="175987" points="4293 500, 4293 600, 4293 698" position="4293 600" lineWidth="1.0"> <Inputs> <Input id="105" points="4233 491" /> <Input id="130" points="4170 427" /> </Inputs> <Outputs> <Output id="127" points="4323 735" /> <Output id="111" points="4084 822, 4292 802" /> </Outputs> <Catalysts> <Catalyst id="500" points="4326 600" /> </Catalysts> <Properties> <displayName>NNMT transfers CH3 from AdoMet to PY</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="137" reactomeId="175976" points="4017 502, 4018 568, 4018 626" position="4018 568" lineWidth="1.0"> <Inputs> <Input id="113" points="3989 489" /> <Input id="130" points="4124 427" /> </Inputs> <Outputs> <Output id="120" points="3956 686" /> <Output id="111" points="4047 808" /> </Outputs> <Catalysts> <Catalyst id="109" points="3932 568" /> </Catalysts> <Properties> <displayName>TMT transfers CH3 from AdoMet to BME</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="146" reactomeId="176059" points="680 1489, 631 1489, 568 1489" position="631 1489" lineWidth="1.0"> <Inputs> <Input id="144" points="811 1489" /> <Input id="145" points="699 1516" /> </Inputs> <Outputs> <Output id="141" /> </Outputs> <Catalysts> <Catalyst id="143" points="631 1600" /> </Catalysts> <Properties> <displayName>GST trimers transfer GS from GSH to luminal substrates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="147" reactomeId="176054" points="1218 1741, 1116 1741, 1066 1740" position="1116 1741" lineWidth="1.0"> <Inputs> <Input id="142" points="1218 1788" /> <Input id="151" points="1283 1741" /> </Inputs> <Outputs> <Output id="139" /> </Outputs> <Catalysts> <Catalyst id="503" points="1115 1712" /> </Catalysts> <Properties> <displayName>GST dimers conjugate GSH with cytosolic substrates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="157" reactomeId="174367" points="1305 1310, 1304 1344, 1304 1374" position="1304 1344" lineWidth="1.0"> <Inputs> <Input id="148" points="1305 1226" /> <Input id="152" points="1487 1310" /> <Input id="345" points="1282 1290" /> </Inputs> <Outputs> <Output id="149" points="1285 1394" /> <Output id="150" points="1320 1387" /> <Output id="154" points="1303 1449" /> </Outputs> <Catalysts> <Catalyst id="156" points="1273 1344" /> </Catalysts> <Properties> <displayName>GCL ligates L-Glu to L-Cys</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="158" reactomeId="174394" points="1304 1539, 1304 1579, 1305 1624" position="1304 1579" lineWidth="1.0"> <Inputs> <Input id="154" points="1303 1486" /> <Input id="346" points="1383 1514" /> <Input id="377" points="1280 1525" /> </Inputs> <Outputs> <Output id="151" points="1305 1723" /> <Output id="381" points="1278 1650" /> <Output id="383" points="1267 1631" /> </Outputs> <Catalysts> <Catalyst id="153" points="1257 1579" /> </Catalysts> <Inhibitors> <Inhibitor id="151" points="1319 1723, 1348 1691, 1348 1578" /> </Inhibitors> <Properties> <displayName>GSS:Mg2+ dimer synthesizes GSH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="169" reactomeId="177157" points="2535 1391, 2535 1350, 2535 1316" position="2535 1350" lineWidth="1.0"> <Inputs> <Input id="160" points="2536 1463" /> <Input id="167" points="2601 1422" /> <Input id="166" points="2489 1424" /> </Inputs> <Outputs> <Output id="159" points="2506 1265" /> <Output id="163" points="2582 1258" /> <Output id="168" points="2623 1309" /> </Outputs> <Catalysts> <Catalyst id="164" points="2500 1349" /> </Catalysts> <Properties> <displayName>phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="170" reactomeId="177160" points="2759 1394, 2759 1426, 2753 1451" position="2759 1426" lineWidth="1.0"> <Inputs> <Input id="161" points="2799 1365" /> <Input id="168" points="2698 1325" /> </Inputs> <Outputs> <Output id="162" points="2786 1468" /> <Output id="167" points="2666 1442" /> </Outputs> <Catalysts> <Catalyst id="165" points="2785 1426" /> </Catalysts> <Properties> <displayName>phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="181" reactomeId="159443" points="3114 1482, 3114 1384, 3114 1300" position="3114 1384" lineWidth="1.0"> <Inputs> <Input id="176" points="3115 1548" /> <Input id="180" points="3188 1521" /> <Input id="179" points="3075 1513" /> </Inputs> <Outputs> <Output id="172" points="3051 1243" /> <Output id="171" points="3195 1250" /> <Output id="174" points="3119 1216" /> </Outputs> <Catalysts> <Catalyst id="175" points="3060 1383" /> </Catalysts> <Properties> <displayName>benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="182" reactomeId="159566" points="3276 1311, 3282 1397, 3281 1478" position="3282 1397" lineWidth="1.0"> <Inputs> <Input id="171" points="3230 1250" /> <Input id="173" points="3320 1248" /> </Inputs> <Outputs> <Output id="178" points="3326 1523" /> <Output id="180" points="3233 1521" /> </Outputs> <Catalysts> <Catalyst id="743" points="3313 1395" /> </Catalysts> <Properties> <displayName>benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="193" reactomeId="159574" points="3503 1292, 3505 1394, 3501 1483" position="3505 1394" lineWidth="1.0"> <Inputs> <Input id="184" points="3461 1250" /> <Input id="191" points="3555 1245" /> </Inputs> <Outputs> <Output id="189" points="3584 1536" /> <Output id="190" points="3450 1522" /> </Outputs> <Catalysts> <Catalyst id="743" points="3450 1394" /> </Catalysts> <Properties> <displayName>GLYAT-like proteins transfer glycine to ST-CoA to form SUA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="194" reactomeId="159567" points="3709 1502, 3709 1402, 3710 1260" position="3709 1402" lineWidth="1.0"> <Inputs> <Input id="189" points="3638 1536" /> <Input id="188" points="3773 1549" /> <Input id="192" points="3709 1556" /> </Inputs> <Outputs> <Output id="183" points="3775 1247" /> <Output id="185" points="3712 1213" /> <Output id="191" points="3606 1233" /> </Outputs> <Catalysts> <Catalyst id="738" points="3741 1406" /> </Catalysts> <Properties> <displayName>ACSM2B-like proteins transform ST to ST-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="348" reactomeId="176606" points="2321 981, 2376 980, 2427 981" position="2376 980" lineWidth="1.0"> <Inputs> <Input id="349" points="2267 994" /> <Input id="64" points="2321 956" /> </Inputs> <Outputs> <Output id="350" points="2494 979" /> <Output id="351" points="2480 944" /> </Outputs> <Catalysts> <Catalyst id="352" points="2373 1003" /> </Catalysts> <Properties> <displayName>Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="354" reactomeId="76386" points="4551 459, 4551 496, 4551 526" position="4551 496" lineWidth="1.0"> <Inputs> <Input id="355" points="4606 443" /> <Input id="356" points="4586 408" /> <Input id="357" points="4624 413" /> <Input id="358" points="4534 426" /> </Inputs> <Outputs> <Output id="359" points="4551 578" /> <Output id="360" points="4642 548" /> <Output id="361" points="4612 517" /> <Output id="362" points="4596 568" /> </Outputs> <Catalysts> <Catalyst id="363" points="4523 496" /> </Catalysts> <Properties> <displayName>CYP1A2 S-demethylates 6MMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="368" reactomeId="1247935" points="1748 1206, 1690 1206, 1661 1206" position="1690 1206" lineWidth="1.0"> <Inputs> <Input id="387" points="1748 1312" /> <Input id="399" stoichiometry="2" points="1792 1237" /> <Input id="400" points="1796 1206" /> </Inputs> <Outputs> <Output id="372" points="1583 1176" /> <Output id="373" points="1598 1160" /> <Output id="148" points="1334 1206" /> </Outputs> <Catalysts> <Catalyst id="374" points="1690 1174" /> </Catalysts> <Properties> <displayName>OPLAH hydrolyses OPRO to L-Glu</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="386" reactomeId="1247922" points="1338 1466, 1582 1466, 1582 1369" position="1582 1466" lineWidth="1.0"> <Inputs> <Input id="154" /> </Inputs> <Outputs> <Output id="387" points="1721 1335" /> <Output id="152" points="1532 1329" /> </Outputs> <Catalysts> <Catalyst id="388" points="1613 1466" /> </Catalysts> <Properties> <displayName>GGCT transforms gGluCys to OPRO</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="428" reactomeId="1247915" points="1305 1760, 1305 1879, 1305 1920" position="1305 1879" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="151" /> </Inputs> <Outputs> <Output id="429" /> </Outputs> <Properties> <displayName>GSH translocates from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="435" reactomeId="1247939" points="1515 1920, 1515 1880, 1515 1689" position="1515 1880" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="433" /> </Inputs> <Outputs> <Output id="437" /> </Outputs> <Properties> <displayName>CysGly translocates from extracellular region to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="441" reactomeId="1247910" points="1515 1628, 1515 1604, 1515 1544" position="1515 1604" lineWidth="1.0"> <Inputs> <Input id="745" points="1554 1647" /> <Input id="437" points="1515 1652" /> </Inputs> <Outputs> <Output id="346" points="1424 1514" /> <Output id="152" points="1515 1329" /> </Outputs> <Catalysts> <Catalyst id="455" points="1553 1603" /> </Catalysts> <Properties> <displayName>CNDP2:2Mn2+ dimer hydrolyses CysGly</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="456" points="1232 489, 1283 483, 1293 481" position="1283 483" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="33" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="457" points="1071 508, 1107 515, 1250 515, 1277 507" position="1178 515" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="62" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="458" points="3074 472, 3055 464, 2568 472, 2524 483" position="2811 468" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="67" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="460" points="1198 510, 1242 534, 2375 547, 2464 518" position="1808 540" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="33" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="461" points="1056 479, 1087 466, 2374 470, 2448 483" position="1730 468" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="62" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="462" points="823 482, 960 445, 1546 446, 1616 476" position="1253 445" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="50" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="463" points="3258 407, 3304 421, 3331 1107, 1107 1113, 1078 1060" position="3331 1107" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="54" /> </Inputs> <Outputs> <Output id="92" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="464" points="844 504, 949 521, 1398 526, 1437 517" position="1173 523" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="465" points="1194 510, 1237 541, 1467 542, 1477 517" position="1352 541" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="33" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="466" points="1190 510, 1227 548, 1936 553, 1982 527" position="1581 550" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="33" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="467" points="1041 508, 1089 565, 1940 567, 1989 527" position="1514 566" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="62" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="468" points="816 482, 957 435, 1844 439, 1960 478" position="1400 437" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="471" points="3148 484, 3260 481, 3402 501" position="3260 481" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="67" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="476" points="3258 410, 3278 420, 3300 1022, 1843 1039" position="3289 721" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="54" /> </Inputs> <Outputs> <Output id="99" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="477" points="3092 501, 3079 555, 2277 559, 2233 523" position="2678 557" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="67" /> </Inputs> <Outputs> <Output id="37" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="479" points="1226 481, 1378 446, 2162 447, 2210 488" position="1770 446" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="33" /> </Inputs> <Outputs> <Output id="37" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="480" points="1043 508, 1095 559, 2116 560, 2199 523" position="1605 559" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="62" /> </Inputs> <Outputs> <Output id="37" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="483" points="2283 503, 2434 500" position="2358 501" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="37" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="484" points="2162 505, 1884 505" position="2023 505" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="37" /> </Inputs> <Outputs> <Output id="29" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="485" points="2162 503, 1541 492" position="1851 497" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="37" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="486" points="2162 504, 1377 498" position="1769 501" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="37" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="487" points="2283 505, 3402 510" position="2842 507" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="37" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="488" points="2162 503, 2066 502" position="2114 502" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="37" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="489" points="2434 500, 1884 504" position="2159 502" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="29" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="490" points="2434 499, 1541 492" position="1987 495" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="491" points="2434 499, 1377 498" position="1905 498" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="492" points="2555 500, 3402 510" position="2978 505" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="493" points="2434 500, 2066 501" position="2250 500" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="494" points="1884 505, 3402 510" position="2643 507" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="29" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="495" points="1596 496, 1541 493" position="1568 494" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="50" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="496" points="1710 500, 1952 501" position="1831 500" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="50" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="497" points="1427 493, 1377 495" position="1402 494" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="44" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="498" points="1541 492, 1952 500" position="1746 496" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="44" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="499" points="1377 498, 1952 501" position="1664 499" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="70" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="717" reactomeId="3301943" points="2310 1243, 2340 1243, 2364 1243" position="2340 1243" lineWidth="1.0"> <Inputs> <Input id="723" points="2281 1225" /> <Input id="718" points="2285 1257" /> </Inputs> <Outputs> <Output id="720" points="2391 1260" /> <Output id="721" points="2399 1224" /> </Outputs> <Catalysts> <Catalyst id="722" points="2340 1211" /> </Catalysts> <Properties> <displayName>GSTK1 dimer transfers GS from GSH to CDNB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="740" points="3741 1422, 3627 1453, 2599 1459, 2469 1381" position="3113 1456" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="738" /> </Inputs> <Outputs> <Output id="164" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="741" points="3761 1387, 3652 1322, 3175 1329, 3060 1363" position="3413 1325" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="738" /> </Inputs> <Outputs> <Output id="175" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="808" reactomeId="5603114" points="4349 249, 4349 305, 4349 361" position="4349 305" lineWidth="1.0"> <Inputs> <Input id="810" points="4349 213" /> <Input id="119" points="4167 141" /> <Input id="112" points="4225 210" /> </Inputs> <Outputs> <Output id="130" points="4180 400" /> <Output id="123" points="4239 361" /> <Output id="813" points="4378 370" /> </Outputs> <Catalysts> <Catalyst id="811" points="4378 305" /> </Catalysts> <Properties> <displayName>MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="821" reactomeId="159194" points="869 1023, 869 1071, 869 1114" position="869 1071" lineWidth="1.0"> <Inputs> <Input id="822" points="869 989" /> <Input id="1594" points="895 1013" /> </Inputs> <Outputs> <Output id="823" points="890 1154" /> <Output id="1596" points="835 1145" /> </Outputs> <Catalysts> <Catalyst id="1691" points="978 1149" /> </Catalysts> <Properties> <displayName>UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="827" reactomeId="159179" points="899 1243, 899 1272, 899 1303" position="899 1272" lineWidth="1.0"> <Inputs> <Input id="823" points="899 1191" /> <Input id="834" points="876 1235" /> </Inputs> <Outputs> <Output id="828" points="875 1319" /> <Output id="836" points="931 1324" /> </Outputs> <Catalysts> <Catalyst id="1691" points="983 1178" /> </Catalysts> <Properties> <displayName>UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="844" reactomeId="5694563" points="2332 1617, 2367 1617, 2406 1617" position="2367 1617" lineWidth="1.0"> <Inputs> <Input id="845" points="2306 1617" /> <Input id="846" points="2313 1596" /> </Inputs> <Outputs> <Output id="847" points="2455 1617" /> <Output id="848" points="2454 1580" /> </Outputs> <Catalysts> <Catalyst id="849" points="2367 1581" /> </Catalysts> <Properties> <displayName>ABHD10 hydrolyses MPAG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1094" reactomeId="5695964" points="3466 223, 3466 257, 3466 287" position="3466 257" lineWidth="1.0"> <Inputs> <Input id="1095" points="3466 202" /> <Input id="1096" points="3485 216" /> </Inputs> <Outputs> <Output id="1097" points="3466 326" /> <Output id="1098" points="3503 314" /> </Outputs> <Catalysts> <Catalyst id="1099" points="3495 257" /> </Catalysts> <Properties> <displayName>ABHD14B hydrolyses PNPB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1107" reactomeId="5692232" points="2910 912, 2942 912, 2985 912" position="2942 912" lineWidth="1.0"> <Inputs> <Input id="1108" points="2863 912" /> <Input id="1109" points="2878 933" /> </Inputs> <Outputs> <Output id="1110" points="3022 912" /> <Output id="1111" points="3010 938" /> </Outputs> <Catalysts> <Catalyst id="1112" points="2942 882" /> </Catalysts> <Properties> <displayName>AKR1A1 oxidises BaPtDHD to BaP-7,8-dione</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1113" reactomeId="5693724" points="912 1429, 912 1466, 890 1489" position="912 1466" lineWidth="1.0"> <Inputs> <Input id="1115" points="892 1411" /> <Input id="1114" points="933 1410" /> </Inputs> <Outputs> <Output id="1116" points="890 1525" /> <Output id="144" points="858 1489" /> </Outputs> <Catalysts> <Catalyst id="1117" points="963 1465" /> </Catalysts> <Properties> <displayName>ESD dimer hydrolyses S-FGSH to GSH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1118" reactomeId="3160769" points="3709 351, 3744 393, 3744 434" position="3744 393" lineWidth="1.0"> <Inputs> <Input id="742" points="3754 351" /> <Input id="1119" points="3672 311" /> </Inputs> <Outputs> <Output id="1120" points="3659 438" /> <Output id="501" points="3664 473" /> </Outputs> <Catalysts> <Catalyst id="742" points="3781 373" /> </Catalysts> <Properties> <displayName>MTR transfers CH3 from MTHFPG to B12s</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1169" reactomeId="5696220" points="4114 1051, 4160 1052, 4200 1052" position="4160 1052" lineWidth="1.0"> <Inputs> <Input id="1170" points="4082 1037" /> <Input id="1174" points="4082 1067" /> </Inputs> <Outputs> <Output id="1171" points="4235 1035" /> <Output id="1176" points="4220 1072" /> </Outputs> <Catalysts> <Catalyst id="1172" points="4159 1019" /> </Catalysts> <Properties> <displayName>AS3MT transfers CH3 from AdoMet to arsenite(3-)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1177" reactomeId="5696213" points="4541 1064, 4542 1097, 4542 1134" position="4542 1097" lineWidth="1.0"> <Inputs> <Input id="1178" points="4540 1033" /> <Input id="1549" points="4580 1054" /> </Inputs> <Outputs> <Output id="1179" points="4542 1175" /> <Output id="1551" points="4580 1148" /> </Outputs> <Catalysts> <Catalyst id="1499" points="4574 1097" /> </Catalysts> <Properties> <displayName>AS3MT transfers CH3 from AdoMet to methylarsonite</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1492" reactomeId="5696230" points="4354 1014, 4408 1014, 4443 1014" position="4408 1014" lineWidth="1.0"> <Inputs> <Input id="1171" points="4319 1014" /> <Input id="1498" stoichiometry="2" points="4337 989" /> </Inputs> <Outputs> <Output id="1493" points="4459 995" /> <Output id="1494" points="4457 1037" /> <Output id="1178" points="4487 1014" /> </Outputs> <Catalysts> <Catalyst id="1495" points="4407 961" /> </Catalysts> <Properties> <displayName>GSTO1 dimer reduces methylarsonate to methylarsonite</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1552" reactomeId="6785928" points="1330 1740, 1465 1740, 1490 1740" position="1465 1740" lineWidth="1.0"> <Inputs> <Input id="151" /> </Inputs> <Outputs> <Output id="437" points="1509 1689" /> <Output id="387" points="1748 1349, 1746 1738" /> </Outputs> <Catalysts> <Catalyst id="1553" points="1465 1767" /> </Catalysts> <Properties> <displayName>CHAC1,2 cleaves GSH to OPRO and CysGly</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1555" reactomeId="6800149" points="3685 178, 3734 178, 3784 178" position="3734 178" lineWidth="1.0"> <Inputs> <Input id="1556" points="3647 178" /> <Input id="1562" points="3638 150" /> </Inputs> <Outputs> <Output id="1557" points="3844 178" /> <Output id="1560" points="3827 152" /> </Outputs> <Catalysts> <Catalyst id="1558" points="3734 139" /> </Catalysts> <Properties> <displayName>N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1568" reactomeId="8943279" points="1361 1937, 1409 1937, 1446 1937" position="1409 1937" lineWidth="1.0"> <Inputs> <Input id="1569" points="1354 1956" /> <Input id="429" points="1329 1937" /> </Inputs> <Outputs> <Output id="433" points="1486 1937" /> <Output id="1570" points="1461 1958" /> </Outputs> <Catalysts> <Catalyst id="434" points="1409 1900" /> </Catalysts> <Properties> <displayName>GGT dimers hydrolyse GSH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1581" reactomeId="8941701" points="542 1239, 542 1275, 542 1305" position="542 1275" lineWidth="1.0"> <Inputs> <Input id="1582" points="542 1217" /> <Input id="1587" points="572 1227" /> </Inputs> <Outputs> <Output id="1583" points="542 1335" /> <Output id="1589" points="581 1316" /> </Outputs> <Catalysts> <Catalyst id="1584" points="484 1275" /> </Catalysts> <Properties> <displayName>UGT1A10 transfers GlcA from UDP-GlcA to GCTN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1604" reactomeId="8953499" points="3215 176, 3257 176, 3288 176" position="3257 176" lineWidth="1.0"> <Inputs> <Input id="1605" points="3143 168" /> <Input id="1606" points="3192 196" /> </Inputs> <Outputs> <Output id="1607" points="3326 144" /> <Output id="1608" points="3306 176" /> </Outputs> <Catalysts> <Catalyst id="1609" points="3257 146" /> </Catalysts> <Inhibitors> <Inhibitor id="1624" points="3257 198" /> </Inhibitors> <Properties> <displayName>IMPAD1 hydrolyses PAP to AMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1620" reactomeId="8954262" points="2912 166, 2959 166, 3030 166" position="2959 166" lineWidth="1.0"> <Inputs> <Input id="1621" points="2901 190" /> <Input id="735" stoichiometry="2" points="2862 166" /> </Inputs> <Outputs> <Output id="1622" points="3058 193" /> <Output id="1605" stoichiometry="2" points="3098 166" /> </Outputs> <Catalysts> <Catalyst id="1623" points="2959 230" /> </Catalysts> <Properties> <displayName>TPST1,2 transfer SO4(2-) from PAPS to PODXL2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1631" reactomeId="9632039" points="892 1029, 892 1059, 892 1112" position="892 1059" lineWidth="1.0"> <Inputs> <Input id="822" points="875 989" /> <Input id="1594" points="910 1013" /> </Inputs> <Outputs> <Output id="823" points="897 1154" /> <Output id="1596" points="844 1148" /> </Outputs> <Catalysts> <Catalyst id="1632" points="950 1059" /> </Catalysts> <Properties> <displayName>UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1633" points="950 1053, 519 958" position="734 1005" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1632" /> </Inputs> <Outputs> <Output id="8" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1634" reactomeId="9632038" points="939 1208, 939 1258, 939 1293" position="939 1258" lineWidth="1.0"> <Inputs> <Input id="823" points="916 1191" /> <Input id="834" points="876 1218" /> </Inputs> <Outputs> <Output id="828" points="875 1323" /> <Output id="836" points="948 1320" /> </Outputs> <Catalysts> <Catalyst id="1674" points="944 1257" /> </Catalysts> <Properties> <displayName>UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1715" reactomeId="9912889" points="482 599, 483 585, 482 599" position="483 585" lineWidth="1.0"> <Inputs> <Input id="1721" points="447 620" /> <Input id="18" points="593 620" /> </Inputs> <Outputs> <Output id="1717" points="420 581" /> <Output id="1718" points="517 627" /> </Outputs> <Catalysts> <Catalyst id="1719" points="482 542" /> </Catalysts> <Properties> <displayName>SLC35D2 exchanges UDP-GlcA for UMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1729" reactomeId="8863761" points="379 527, 378 477, 378 440" position="378 477" lineWidth="1.0"> <Inputs> <Input id="1730" points="335 538" /> <Input id="1717" points="379 553" /> </Inputs> <Outputs> <Output id="1731" points="377 400" /> <Output id="1732" points="340 428" /> </Outputs> <Catalysts> <Catalyst id="1733" points="446 477" /> </Catalysts> <Properties> <displayName>UXS1 tetramer decarboxylates UDP-glucuronate to UDP-xylose</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1735" interactionType="Activate" points="2487 144, 2347 163" position="2417 153" lineWidth="2.0"> <Inputs> <Input id="1734" /> </Inputs> <Outputs> <Output id="55" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1736" interactionType="Activate" points="2635 142, 2811 163" position="2723 152" lineWidth="2.0"> <Inputs> <Input id="1734" /> </Inputs> <Outputs> <Output id="735" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1754" reactomeId="9971063" points="2774 1282, 2821 1282, 2859 1280" position="2821 1282" lineWidth="1.0"> <Inputs> <Input id="168" points="2742 1288" /> <Input id="1751" points="2699 1249" /> </Inputs> <Outputs> <Output id="1755" points="2910 1237" /> <Output id="1745" points="2900 1290" /> <Output id="1753" points="2926 1265" /> </Outputs> <Catalysts> <Catalyst id="1747" points="2819 1222" /> </Catalysts> <Properties> <displayName>GLYAT-like proteins transfer glycine to phenylacetyl-CoA</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1758" reactomeId="9972916" points="2828 1572, 2795 1572, 2760 1572" position="2795 1572" lineWidth="1.0"> <Inputs> <Input id="1759" points="2883 1591" /> <Input id="1764" points="2892 1555" /> </Inputs> <Outputs> <Output id="167" points="2647 1459" /> <Output id="1760" points="2715 1605" /> <Output id="1766" points="2672 1574" /> </Outputs> <Catalysts> <Catalyst id="1762" points="2795 1627" /> </Catalysts> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Phase II - Conjugation of compounds, Defective AHCY causes HMAHCHD, Defective GCLC causes HAGGSD, Defective GGT1 causes GLUTH, Defective GSS causes GSS deficiency, Defective MAT1A causes MATD, Defective OPLAH causes OPLAHD, Defective SLC35D1 causes SCHBCKD, and Defective TPMT causes TPMT deficiency (500771)
