Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Apoptotic execution phase

Class:IdPathwayDiagram:500685
_displayNameDiagram of Apoptotic execution phase
_timestamp2018-02-27 03:57:48
created[InstanceEdit:500686] Matthews, L, 2010-02-04
height1876
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:1933180] Rothfels, K, 2011-11-02
[InstanceEdit:3006830] Jassal, B, 2013-02-01
[InstanceEdit:3010067] Jassal, B, 2013-02-05
[InstanceEdit:3604378] Matthews, L, 2013-05-22
[InstanceEdit:3877114] D'Eustachio, P, 2013-07-10
[InstanceEdit:4393426] Orlic-Milacic, M, 2013-08-22
[InstanceEdit:6797649] Garapati, Phani Vijay, 2015-09-15
[InstanceEdit:6809555] Shamovsky, Veronica, 2015-11-11
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:9029654] Orlic-Milacic, Marija, 2017-11-21
[InstanceEdit:9029666] Orlic-Milacic, Marija, 2017-11-21
[InstanceEdit:9029670] Orlic-Milacic, Marija, 2017-11-21
[InstanceEdit:9029673] Orlic-Milacic, Marija, 2017-11-21
[InstanceEdit:9029683] Orlic-Milacic, Marija, 2017-11-21
[InstanceEdit:9029684] Orlic-Milacic, Marija, 2017-11-21
[InstanceEdit:9029712] Orlic-Milacic, Marija, 2017-11-21
[InstanceEdit:9029726] Orlic-Milacic, Marija, 2017-11-21
[InstanceEdit:9029729] Orlic-Milacic, Marija, 2017-11-21
[InstanceEdit:9029827] Orlic-Milacic, Marija, 2017-11-22
[InstanceEdit:9029871] Orlic-Milacic, Marija, 2017-11-22
[InstanceEdit:9029872] Orlic-Milacic, Marija, 2017-11-22
[InstanceEdit:9029992] Orlic-Milacic, Marija, 2017-11-24
[InstanceEdit:9029993] Orlic-Milacic, Marija, 2017-11-24
[InstanceEdit:9029997] Orlic-Milacic, Marija, 2017-11-24
[InstanceEdit:9038447] Matthews, Lisa, 2018-02-27
representedPathway[Pathway:75153] Apoptotic execution phase [Homo sapiens]
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textPosition="2280 1036" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="721" reactomeId="211225" position="2302 1174" bounds="2262 1162 80 25" textPosition="2267 1166" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>DFFA:DFFB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="722" reactomeId="211208" position="2301 1279" bounds="2242 1261 119 36" textPosition="2247 1262" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Caspase cleaved DFFA (117)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="723" reactomeId="211223" position="2172 1277" bounds="2115 1266 115 22" textPosition="2119 1267" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>active caspase-3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="725" reactomeId="211196" 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bounds="2061 1386 93 22" textPosition="2061 1386"> <Properties> <displayName>SATB1(1-254)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1667" reactomeId="352264" position="1988 1400" bounds="1934 1389 109 22" textPosition="1934 1389"> <Properties> <displayName>SATB1(255-763)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="1700" reactomeId="5460" position="1220 1447" bounds="855 1347 731 201" textPosition="889 1501" bgColor="250 240 240" lineColor="255 153 102" insets="865 1357 709 180"> <Properties> <displayName>mitochondrial matrix</displayName> </Properties> <Components> <Component id="1997" /> <Component id="1983" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="1982" reactomeId="351943" position="1297 1272" bounds="1272 1261 51 22" textPosition="1272 1261"> <Properties> <displayName>DNM1L</displayName> </Properties> 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bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>active caspase-8</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1999" reactomeId="58200" position="606 198" bounds="558 187 96 22" textPosition="582 187"> <Properties> <displayName>PRKCD</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2000" reactomeId="3209845" position="145 383" bounds="127 372 36 22" textPosition="127 372"> <Properties> <displayName>TJP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2001" reactomeId="3209844" position="164 491" bounds="129 480 70 22" textPosition="132 480"> <Properties> <displayName>TJP1 (?-?)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2002" reactomeId="2530516" position="304 380" bounds="261 369 87 22" textPosition="261 369"> <Properties> <displayName>FNTA(2-379)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2003" reactomeId="350870" position="1170 705" bounds="1124 695 92 21" textPosition="1134 695" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Caspase-3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2080" reactomeId="350267" position="2475 1187" bounds="2425 1163 101 49" textPosition="2426 1163" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>importin-alpha:importin-beta complex</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="1" reactomeId="201608" points="902 227, 935 227, 958 227" position="935 227" lineWidth="1.0"> <Inputs> <Input id="2" /> </Inputs> <Outputs> <Output id="3" points="980 196" /> <Output id="4" points="1001 227" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1162 692, 882 319" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of alpha adducin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6" reactomeId="202967" points="1214 232, 1244 232, 1274 232" position="1244 232" lineWidth="1.0"> <Inputs> <Input id="7" /> </Inputs> <Outputs> <Output id="8" points="1303 219" /> <Output id="9" points="1306 253" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1171 692" /> </Catalysts> <Properties> <displayName>Caspase mediated cleavage of alpha-II-Fodrin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10" reactomeId="201639" points="534 990, 560 990, 598 990" position="560 990" lineWidth="1.0"> <Inputs> <Input id="11" /> </Inputs> <Outputs> <Output id="12" points="656 1004" /> <Output id="13" points="648 982" /> </Outputs> <Catalysts> <Catalyst id="14" points="557 1028" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of GAS2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15" reactomeId="202966" points="1495 253, 1528 253, 1561 253" position="1528 253" lineWidth="1.0"> <Inputs> <Input id="16" /> </Inputs> <Outputs> <Output id="17" points="1594 230" /> <Output id="18" points="1595 271" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1179 692, 1529 295" /> </Catalysts> <Properties> <displayName>Caspase mediated cleavage of HIP-55</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="19" reactomeId="201628" points="519 1129, 562 1128, 594 1129" position="562 1128" lineWidth="1.0"> <Inputs> <Input id="20" /> </Inputs> <Outputs> <Output id="21" points="626 1146" /> <Output id="22" points="628 1110" /> </Outputs> <Catalysts> <Catalyst id="14" points="557 1072" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of vimentin at DSVD (85)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="23" reactomeId="350319" points="471 1145, 471 1183, 431 1183" position="471 1183" lineWidth="1.0"> <Inputs> <Input id="20" /> </Inputs> <Outputs> <Output id="24" points="404 1221" /> <Output id="25" points="381 1183" /> </Outputs> <Catalysts> <Catalyst id="1993" points="473 1328" /> </Catalysts> <Properties> <displayName>Caspase mediated cleavage of vimentin at IDVD (259)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="55" reactomeId="350318" points="487 1145, 555 1190, 577 1202" position="555 1190" lineWidth="1.0"> <Inputs> <Input id="20" /> </Inputs> <Outputs> <Output id="56" points="666 1266" /> <Output id="57" points="640 1213" /> </Outputs> <Catalysts> <Catalyst id="58" points="542 1223" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of vimentin at TNLD (429)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="59" reactomeId="201622" points="1578 373, 1618 373, 1653 373" position="1618 373" lineWidth="1.0"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="61" points="1684 355" /> <Output id="62" points="1685 391" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1186 692, 1618 414" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of gelsolin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="63" reactomeId="201637" points="428 1438, 472 1438, 472 1461" position="472 1438" lineWidth="1.0"> <Inputs> <Input id="64" /> </Inputs> <Outputs> <Output id="65" points="527 1487" /> <Output id="66" points="423 1486" /> </Outputs> <Catalysts> <Catalyst id="1993" points="473 1356" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of plectin-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="67" reactomeId="201629" points="1700 456, 1728 456, 1765 456" position="1728 456" lineWidth="1.0"> <Inputs> <Input id="68" /> </Inputs> <Outputs> <Output id="69" points="1803 475" /> <Output id="70" points="1802 435" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1197 692, 1728 495" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Tau</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="72" reactomeId="202939" points="1406 99, 1452 86, 1489 116, 1559 74" position="1489 116" lineWidth="1.0"> <Inputs> <Input id="73" /> </Inputs> <Outputs> <Output id="74" points="1583 102" /> <Output id="75" points="1672 102" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1175 692" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of E-Cadherin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="77" reactomeId="202969" points="1990 464, 2034 464, 2071 464" position="2034 464" lineWidth="1.0"> <Inputs> <Input id="78" /> </Inputs> <Outputs> <Output id="79" points="2109 439" /> <Output id="80" points="2112 483" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1215 692, 2034 506" /> </Catalysts> <Properties> <displayName>Caspase mediated cleavage of beta-catenin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="109" reactomeId="201631" points="321 117, 395 119, 446 125" position="395 119" lineWidth="1.0"> <Inputs> <Input id="110" /> </Inputs> <Outputs> <Output id="111" points="546 123" /> <Output id="112" points="505 144" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1156 692, 719 364" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Desmoglein 3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="113" reactomeId="351877" points="734 117, 771 121, 803 118" position="771 121" lineWidth="1.0"> <Inputs> <Input id="114" /> </Inputs> <Outputs> <Output id="115" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1161 692, 840 306" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Desmoglein 2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="116" reactomeId="201636" points="143 209, 145 248, 146 291" position="145 248" lineWidth="1.0"> <Inputs> <Input id="117" /> </Inputs> <Outputs> <Output id="118" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1151 692, 538 341" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Desmoplakin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="206" reactomeId="202917" points="993 115, 1066 120, 1104 123" position="1066 120" lineWidth="1.0"> <Inputs> <Input id="207" /> </Inputs> <Outputs> <Output id="208" points="1152 120" /> <Output id="209" points="1171 159" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1169 692, 1152 270" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Desmoglein 1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="238" reactomeId="201595" points="149 848, 146 887, 146 938" position="146 887" lineWidth="1.0"> <Inputs> <Input id="239" /> </Inputs> <Outputs> <Output id="240" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1121 713" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of plakophilin-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="270" reactomeId="351913" points="145 397, 146 436, 160 477" position="146 436" lineWidth="1.0"> <Inputs> <Input id="2000" /> </Inputs> <Outputs> <Output id="2001" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1140 692, 555 484" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of TJP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="385" reactomeId="351871" points="146 606, 147 649, 147 688" position="147 649" lineWidth="1.0"> <Inputs> <Input id="386" /> </Inputs> <Outputs> <Output id="387" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1121 704, 302 695" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Z0-2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="444" reactomeId="351876" points="133 1048, 108 1065, 144 1094, 89 1126" position="144 1094" lineWidth="1.0"> <Inputs> <Input id="445" /> </Inputs> <Outputs> <Output id="446" points="122 1127" /> <Output id="447" points="141 1171" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1121 714, 304 877, 217 1092" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of occludin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="448" reactomeId="264865" points="1846 1387, 1826 1393, 1769 1450" position="1826 1393" lineWidth="1.0"> <Inputs> <Input id="449" /> </Inputs> <Outputs> <Output id="450" points="1802 1450" /> <Output id="451" points="1802 1508, 1787 1508" /> </Outputs> <Catalysts> <Catalyst id="452" points="1794 1336, 1796 1336, 1777 1356, 1778 1392" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Lamin A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="453" reactomeId="264871" points="1824 1274, 1792 1255, 1829 1219, 1787 1179" position="1829 1219" lineWidth="1.0"> <Inputs> <Input id="454" /> </Inputs> <Outputs> <Output id="455" points="1810 1176" /> <Output id="456" points="1813 1139, 1812 1140" /> </Outputs> <Catalysts> <Catalyst id="452" points="1791 1316, 1778 1314, 1779 1219" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Lamin B1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="514" reactomeId="202947" points="371 640, 402 640, 437 640" position="402 640" lineWidth="1.0"> <Inputs> <Input id="1994" /> </Inputs> <Outputs> <Output id="1995" points="475 620" /> <Output id="1996" points="512 648" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1121 703, 402 675" /> </Catalysts> <Properties> <displayName>Caspase mediated cleavage of APC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="518" reactomeId="202960" points="375 760, 418 760, 460 760" position="418 760" lineWidth="1.0"> <Inputs> <Input id="519" /> </Inputs> <Outputs> <Output id="520" points="503 760" /> <Output id="521" points="473 738" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1121 711, 418 812" /> </Catalysts> <Properties> <displayName>Caspase mediated cleavage of C-IAP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="522" reactomeId="201634" points="504 881, 503 901, 502 922" position="503 901" lineWidth="1.0"> <Inputs> <Input id="523" /> </Inputs> <Outputs> <Output id="524" points="470 933" /> <Output id="525" points="534 934" /> </Outputs> <Catalysts> <Catalyst id="526" points="403 902" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of FADK 1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="527" reactomeId="212552" points="623 212, 682 246, 713 246" position="682 246" lineWidth="1.0"> <Inputs> <Input id="1999" /> </Inputs> <Outputs> <Output id="529" points="718 224" /> <Output id="530" points="740 259" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1157 692, 685 296" /> </Catalysts> <Properties> <displayName>Caspase 3-mediated cleavage of PKC delta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="531" reactomeId="201603" points="256 210, 284 214, 321 214" position="284 214" lineWidth="1.0"> <Inputs> <Input id="532" /> </Inputs> <Outputs> <Output id="533" points="411 234" /> <Output id="534" points="341 185" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1152 692, 531 321, 288 267" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of PKC theta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="535" reactomeId="201630" points="962 337, 989 337, 1026 337" position="989 337" lineWidth="1.0"> <Inputs> <Input id="536" /> </Inputs> <Outputs> <Output id="537" points="1063 322" /> <Output id="538" points="1072 360" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1164 692" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Acinus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="567" reactomeId="201611" points="374 541, 421 541, 469 537" position="421 541" lineWidth="1.0"> <Inputs> <Input id="568" /> </Inputs> <Outputs> <Output id="569" points="493 521" /> <Output id="570" points="507 545" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1121 696, 423 569" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Rock-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="599" reactomeId="201640" points="351 378, 387 378, 422 378" position="387 378" lineWidth="1.0"> <Inputs> <Input id="2002" /> </Inputs> <Outputs> <Output id="601" points="461 386" /> <Output id="602" points="445 366" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1142 692, 482 443" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="603" reactomeId="351894" points="888 1205, 918 1178, 969 1221, 1080 1178" position="969 1221" lineWidth="1.0"> <Inputs> <Input id="604" /> </Inputs> <Outputs> <Output id="605" points="1091 1253" /> <Output id="606" points="1240 1209" /> <Output id="607" points="1140 1210" /> </Outputs> <Catalysts> <Catalyst id="1997" points="971 1338" /> </Catalysts> <Properties> <displayName>Caspase mediated cleavage of BAP31</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="610" reactomeId="351849" points="1919 590, 1952 590, 1982 590" position="1952 590" lineWidth="1.0"> <Inputs> <Input id="611" /> </Inputs> <Outputs> <Output id="612" points="2012 609" /> <Output id="613" points="2009 572" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1219 700, 1952 629" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of Etk</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="642" reactomeId="350651" points="1784 704, 1814 704, 1849 704" position="1814 704" lineWidth="1.0"> <Inputs> <Input id="643" /> </Inputs> <Outputs> <Output id="644" points="1894 722" /> <Output id="645" points="1891 685" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1219 708, 1813 748" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of MASK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="646" reactomeId="351901" points="2616 818, 2617 866, 2617 900" position="2617 866" lineWidth="1.0"> <Inputs> <Input id="647" /> </Inputs> <Outputs> <Output id="648" points="2677 938" /> <Output id="649" points="2564 938" /> </Outputs> <Catalysts> <Catalyst id="14" points="606 1052, 1629 1115, 1744 1848, 2823 1846, 2820 868" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of MST3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="678" reactomeId="351936" points="2126 1631, 2127 1664, 2129 1687" position="2127 1664" lineWidth="1.0"> <Inputs> <Input id="679" /> </Inputs> <Outputs> <Output id="680" points="2092 1702" /> <Output id="681" points="2174 1703" /> </Outputs> <Catalysts> <Catalyst id="682" points="2088 1664" /> </Catalysts> <Properties> <displayName>Caspase-mediated cleavage of claspin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="711" reactomeId="211224" points="2342 726, 2342 746, 2342 774" position="2342 746" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="712" stoichiometry="2" points="2395 698" /> <Input id="713" stoichiometry="2" points="2300 698" /> </Inputs> <Outputs> <Output id="714" /> </Outputs> <Properties> <displayName>Association of DFF40 with DFF45</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="715" reactomeId="211191" points="2342 838, 2343 861, 2343 900" position="2343 861" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="716" points="2372 838" /> <Input id="714" points="2342 805" /> </Inputs> <Outputs> <Output id="717" /> </Outputs> <Properties> <displayName>Association of DFF with alpha:beta importin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="718" reactomeId="211206" points="2343 970, 2343 1001, 2343 1032" position="2343 1001" lineWidth="1.0"> <Inputs> <Input id="717" /> </Inputs> <Outputs> <Output id="719" /> </Outputs> <Properties> <displayName>Translocation of DFF to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="720" reactomeId="211190" points="2301 1190, 2301 1223, 2301 1258" position="2301 1223" lineWidth="1.0"> <Inputs> <Input id="721" /> </Inputs> <Outputs> <Output id="722" /> </Outputs> <Catalysts> <Catalyst id="723" points="2179 1263, 2209 1223" /> </Catalysts> <Properties> <displayName>Caspase 3-mediated cleavage of DFF45 (117)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="724" reactomeId="211186" points="2300 1300, 2300 1325, 2301 1363" position="2300 1325" lineWidth="1.0"> <Inputs> <Input id="722" /> </Inputs> <Outputs> <Output id="725" /> </Outputs> <Catalysts> <Catalyst id="723" points="2182 1291, 2215 1324" /> </Catalysts> <Properties> <displayName>Cleavage of DFF45 (224) by caspase-3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="726" reactomeId="211207" points="2301 1419, 2301 1449, 2301 1471" position="2301 1449" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="725" /> </Inputs> <Outputs> <Output id="727" stoichiometry="2" points="2353 1516" /> <Output id="728" stoichiometry="2" points="2367 1472" /> <Output id="729" stoichiometry="2" points="2254 1522" /> <Output id="730" stoichiometry="2" points="2236 1472" /> </Outputs> <Properties> <displayName>Cleaved fragments of DFF45 dissociate from DFF40</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="759" reactomeId="211193" points="2365 1544, 2365 1579, 2365 1602" position="2365 1579" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="727" stoichiometry="2" /> </Inputs> <Outputs> <Output id="760" /> </Outputs> <Properties> <displayName>Homodimerization of DFF40</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="761" reactomeId="211239" points="2685 1590, 2685 1614, 2685 1646" position="2685 1614" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="762" points="2588 1591" /> <Input id="763" points="2685 1578" /> </Inputs> <Outputs> <Output id="764" /> </Outputs> <Properties> <displayName>Association of DFF40 with chromatin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="765" reactomeId="211247" points="2685 1688, 2685 1729, 2684 1752" position="2685 1729" lineWidth="1.0"> <Inputs> <Input id="764" /> </Inputs> <Outputs> <Output id="766" points="2667 1769" /> <Output id="762" points="2523 1559, 2523 1516, 2757 1513, 2756 1751" /> </Outputs> <Catalysts> <Catalyst id="764" points="2709 1688, 2716 1690, 2716 1728" /> </Catalysts> <Activators> <Activator id="1477" points="2550 1765" /> </Activators> <Properties> <displayName>Cleavage of DNA by DFF40</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1075" reactomeId="211651" points="1476 847, 1537 847, 1575 847" position="1537 847" lineWidth="1.0"> <Inputs> <Input id="1076" /> </Inputs> <Outputs> <Output id="1077" points="1772 847" /> <Output id="1078" points="1661 806" /> </Outputs> <Catalysts> <Catalyst id="2003" points="1205 719, 1537 813" /> </Catalysts> <Properties> <displayName>Cleavage of PAK-2 at 212</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1079" reactomeId="211650" points="1902 881, 1902 907, 1902 936" position="1902 907" lineWidth="1.0"> <Inputs> <Input id="1077" points="1851 862" /> <Input id="1080" points="1925 864" /> </Inputs> <Outputs> <Output id="1081" points="1968 935" /> <Output id="1082" points="1902 954" /> </Outputs> <Catalysts> <Catalyst id="1077" points="1826 862, 1826 908" /> </Catalysts> <Properties> <displayName>Autophosphorylation of PAK-2p34 in the activation loop</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1111" reactomeId="211712" points="2026 954, 2026 1002, 2026 1030" position="2026 1002" lineWidth="1.0"> <Inputs> <Input id="1081" /> </Inputs> <Outputs> <Output id="1112" /> </Outputs> <Properties> <displayName>Proteolytic PAK-2p34 fragment translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1293" reactomeId="211219" points="1176 719, 1386 1073, 1829 1072, 2153 1263" position="1829 1072" lineWidth="1.0"> <Inputs> <Input id="2003" /> </Inputs> <Outputs> <Output id="723" /> </Outputs> <Properties> <displayName>Translocation of caspase-3 to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1474" reactomeId="266204" points="2489 1717, 2489 1731, 2489 1760" position="2489 1731" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1475" points="2468 1701" /> <Input id="1476" points="2521 1705" /> </Inputs> <Outputs> <Output id="1477" /> </Outputs> <Properties> <displayName>Association of HMGB1/HMGB2 with chromatin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1664" reactomeId="352268" points="1987 1294, 1987 1326, 1988 1358" position="1987 1326" lineWidth="1.0"> <Inputs> <Input id="1665" /> </Inputs> <Outputs> <Output id="1666" points="2073 1383" /> <Output id="1667" points="1988 1386" /> </Outputs> <Catalysts> <Catalyst id="452" points="1912 1327" /> </Catalysts> <Properties> <displayName>Cleavage of Satb1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1763" reactomeId="351863" points="535 1344, 731 1351, 912 1351" position="731 1351" lineWidth="1.0"> <Inputs> <Input id="1993" /> </Inputs> <Outputs> <Output id="1997" /> </Outputs> <Properties> <displayName>Translocation of active caspase-8 to the mitochondrial membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1981" reactomeId="351948" points="1294 1286, 1288 1310, 1292 1344" position="1288 1310" lineWidth="1.0"> <Inputs> <Input id="1982" /> </Inputs> <Outputs> <Output id="1983" /> </Outputs> <Activators> <Activator id="607" points="1176 1238" /> </Activators> <Properties> <displayName>Mitochondrial recruitment of Drp1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1984" reactomeId="351947" points="2693 966, 2693 1001, 2694 1065" position="2693 1001" lineWidth="1.0"> <Inputs> <Input id="648" /> </Inputs> <Outputs> <Output id="1985" /> </Outputs> <Properties> <displayName>Nuclear translocation of catalytic domain of Mst3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1986" reactomeId="211583" points="1673 953, 1626 952, 1574 950" position="1626 952" lineWidth="1.0"> <Inputs> <Input id="1987" points="1725 952" /> <Input id="1988" stoichiometry="5" points="1705 981" /> </Inputs> <Outputs> <Output id="1076" points="1437 867" /> <Output id="1989" stoichiometry="5" points="1532 981" /> </Outputs> <Catalysts> <Catalyst id="1987" points="1771 938, 1772 919, 1625 919" /> </Catalysts> <Properties> <displayName>Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1991" points="358 917, 368 1046, 506 1049" position="368 1046" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="526" /> </Inputs> <Outputs> <Output id="14" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1992" points="2419 1602, 2459 1597" position="2439 1599" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="760" /> </Inputs> <Outputs> <Output id="762" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2004" points="1167 719, 1088 1035, 606 1048" position="1088 1035" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2003" /> </Inputs> <Outputs> <Output id="14" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2079" reactomeId="9029667" points="2359 1102, 2372 1125, 2390 1156" position="2372 1125" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="719" /> </Inputs> <Outputs> <Output id="2080" points="2422 1168" /> <Output id="721" points="2345 1165" /> </Outputs> <Properties> <displayName>DFF dissociates from importin-alpha:importin-beta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2264" reactomeId="9029680" points="354 917, 255 1225, 334 1681, 1967 1664" position="334 1681" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="526" /> </Inputs> <Outputs> <Output id="682" /> </Outputs> <Properties> <displayName>Caspase-7 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2370" reactomeId="9029690" points="542 1251, 685 1653, 1563 1640, 1731 1330, 1791 1328" position="1563 1640" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="58" /> </Inputs> <Outputs> <Output id="452" /> </Outputs> <Properties> <displayName>Caspase-6 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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