Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Signaling by VEGF

Class:IdPathwayDiagram:500413
_displayNameDiagram of Signaling by VEGF
_timestamp2026-03-02 10:03:21
created[InstanceEdit:500412] Jupe, S, 2010-02-03
height1066
modified[InstanceEdit:2193078] Wu, G, 2012-04-11
[InstanceEdit:3051450] Jupe, S, 2013-02-06
[InstanceEdit:5545456] Garapati, P V, 2014-05-21
[InstanceEdit:5545459] Garapati, P V, 2014-05-21
[InstanceEdit:5566468] Garapati, P V, 2014-05-22
[InstanceEdit:5691350] Rothfels, Karen, 2015-05-06
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8863087] Garapati, Phani Vijay, 2016-03-04
[InstanceEdit:8939806] Jupe, Steve, 2016-09-21
[InstanceEdit:8951589] Jupe, Steve, 2016-12-08
[InstanceEdit:9016836] Jassal, Bijay, 2017-08-16
[InstanceEdit:9026743] Rothfels, Karen, 2017-10-23
[InstanceEdit:9026745] Rothfels, Karen, 2017-10-23
[InstanceEdit:9026959] Rothfels, Karen, 2017-10-24
[InstanceEdit:9628539] D'Eustachio, Peter, 2018-11-09
[InstanceEdit:9628595] Shamovsky, Veronica, 2018-11-09
[InstanceEdit:9674879] Orlic-Milacic, Marija, 2020-01-28
[InstanceEdit:9691218] Jassal, Bijay, 2020-06-10
[InstanceEdit:9691225] Jassal, Bijay, 2020-06-10
[InstanceEdit:9698117] Jassal, Bijay, 2020-08-24
[InstanceEdit:9768032] Shamovsky, Veronica, 2022-03-03
[InstanceEdit:9796646] Shamovsky, Veronica, 2022-08-10
[InstanceEdit:9836717] Stephan, Ralf, 2023-06-01
[InstanceEdit:9911310] D'Eustachio, Peter, 2024-05-28
[InstanceEdit:9947398] D'Eustachio, Peter, 2025-05-05
[InstanceEdit:9947447] D'Eustachio, Peter, 2025-05-05
[InstanceEdit:9970217] D'Eustachio, Peter, 2025-10-29
[InstanceEdit:9983952] Orlic-Milacic, Marija, 2026-03-02
representedPathway[Pathway:194138] Signaling by VEGF [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="1164" reactomeDiagramId="500413"> <Properties> <displayName>Diagram of Signaling by VEGF</displayName> </Properties> <Nodes> <org.gk.render.RenderableEntitySet id="2" reactomeId="195361" position="85 35" bounds="55 22 60 26" textPosition="65 24"> <Properties> <displayName>VEGF</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="4" reactomeId="195389" position="56 140" bounds="4 120 105 40" textPosition="10 122" bgColor="204 255 255"> <Properties> <displayName>VEGFA,VEGFB,PGF dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="5" reactomeId="195396" position="182 215" bounds="111 199 143 33" textPosition="111 196" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFR1 dimer:VEGFA, VEGFB, PGF dimers</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="6" reactomeId="195393" position="565 104" bounds="523 86 84 37" textPosition="527 86" bgColor="204 255 255"> <Properties> <displayName>VEGFA,C,D dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="7" reactomeId="195382" position="698 215" bounds="669 203 59 25" textPosition="671 204"> <Properties> <displayName>VEGFR2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="8" reactomeId="215139" position="554 217" bounds="509 201 90 33" textPosition="518 198" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFR2:VEGFA,C,D</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="9" reactomeId="195359" position="317 216" bounds="288 203 59 26" textPosition="299 205"> <Properties> <displayName>FLT4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="10" reactomeId="195391" position="266 153" bounds="210 137 112 33" textPosition="219 136" bgColor="204 255 255"> <Properties> <displayName>VEGFC,VEGFD dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="11" reactomeId="215140" position="414 220" bounds="364 197 100 47" textPosition="365 194" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFR3 dimer:VEGFC, VEGFD dimers</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="12" reactomeId="195419" position="52 482" bounds="4 465 96 34" textPosition="5 463" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NRP1:VEGFR2 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="13" reactomeId="195427" position="50 325" bounds="1 307 98 36" textPosition="3 307" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NRP2:VEGFR1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="14" reactomeId="3004464" position="45 218" bounds="4 204 83 28" textPosition="18 207" lineWidth="1.0"> <Properties> <displayName>VEGFR1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="15" reactomeId="3008773" position="37 384" bounds="12 373 50 22" textPosition="17 373"> <Properties> <displayName>NRP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="16" reactomeId="549042" position="28 271" bounds="8 260 41 22" textPosition="9 260"> <Properties> <displayName>NRP2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="26" reactomeId="195402" position="855 216" bounds="808 199 94 35" textPosition="809 198" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA-165 dimer:VEGFR2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="27" reactomeId="4420101" position="1078 217" bounds="1028 195 100 45" textPosition="1033 190" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="29" reactomeId="4420213" position="1118 267" bounds="1101 256 34 22" textPosition="1102 256"> <Properties> <displayName>SHB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="30" reactomeId="4420196" position="1259 218" bounds="1210 195 98 47" textPosition="1214 192" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:SHB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="31" reactomeId="113592" position="1315 271" bounds="1295 256 40 30" textPosition="1300 260" /> <org.gk.render.RenderableComplex id="32" reactomeId="4420164" position="1469 216" bounds="1419 191 101 50" textPosition="1419 191" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="33" reactomeId="29370" position="1440 279" bounds="1420 264 41 30" textPosition="1424 268" /> <org.gk.render.RenderableProtein id="34" reactomeId="354153" position="1359 317" bounds="1336 306 46 22" textPosition="1337 306"> <Properties> <displayName>SRC-1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="35" reactomeId="201621" position="1528 283" bounds="1509 272 39 22" textPosition="1510 272"> <Properties> <displayName>PTK2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="36" reactomeId="4420141" position="1644 216" bounds="1602 192 85 48" textPosition="1603 190" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:PTK2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="37" reactomeId="113592" position="1678 279" bounds="1658 264 40 30" textPosition="1663 268" /> <org.gk.render.RenderableComplex id="38" reactomeId="5218639" position="1838 216" bounds="1781 191 114 50" textPosition="1783 191" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="39" reactomeId="29370" position="1799 279" bounds="1779 264 41 30" textPosition="1783 268" /> <org.gk.render.RenderableCompartment id="40" reactomeId="70101" position="3580 601" bounds="20 205 7120 792" textPosition="3584 468" bgColor="250 240 240" lineColor="255 153 102" insets="41 228 7013 745"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="237" /> <Component id="26" /> <Component id="27" /> <Component id="238" /> <Component id="29" /> <Component id="30" /> <Component id="239" /> <Component id="31" /> <Component id="32" /> <Component id="33" /> <Component id="34" /> <Component id="240" /> <Component id="35" /> <Component id="36" /> <Component id="37" /> <Component id="244" /> <Component id="45" /> <Component id="46" /> <Component id="249" /> <Component id="56" /> <Component id="57" /> <Component id="58" /> <Component id="250" /> <Component id="59" /> <Component id="60" /> <Component id="87" /> <Component id="88" /> <Component id="89" /> <Component id="263" /> <Component id="90" /> <Component id="91" /> <Component id="264" /> <Component id="92" /> <Component id="265" /> <Component id="93" /> <Component id="94" /> <Component id="95" /> <Component id="266" /> <Component id="96" /> <Component id="97" /> <Component id="267" /> <Component id="98" /> <Component id="99" /> <Component id="100" /> <Component id="241" /> <Component id="38" /> <Component id="39" /> <Component id="242" /> <Component id="41" /> <Component id="243" /> <Component id="42" /> <Component id="43" /> <Component id="44" /> <Component id="245" /> <Component id="47" /> <Component id="48" /> <Component id="246" /> <Component id="49" /> <Component id="51" /> <Component id="247" /> <Component id="52" /> <Component id="248" /> <Component id="53" /> <Component id="54" /> <Component id="55" /> <Component id="251" /> <Component id="61" /> <Component id="62" /> <Component id="63" /> <Component id="252" /> <Component id="64" /> <Component id="65" /> <Component id="253" /> <Component id="66" /> <Component id="67" /> <Component id="68" /> <Component id="254" /> <Component id="69" /> <Component id="70" /> <Component id="255" /> <Component id="71" /> <Component id="72" /> <Component id="73" /> <Component id="256" /> <Component id="74" /> <Component id="257" /> <Component id="258" /> <Component id="75" /> <Component id="76" /> <Component id="259" /> <Component id="77" /> <Component id="78" /> <Component id="260" /> <Component id="80" /> <Component id="81" /> <Component id="261" /> <Component id="83" /> <Component id="84" /> <Component id="85" /> <Component id="86" /> <Component id="268" /> <Component id="101" /> <Component id="102" /> <Component id="269" /> <Component id="103" /> <Component id="270" /> <Component id="104" /> <Component id="105" /> <Component id="106" /> <Component id="107" /> <Component id="271" /> <Component id="108" /> <Component id="273" /> <Component id="109" /> <Component id="110" /> <Component id="111" /> <Component id="292" /> <Component id="159" /> <Component id="160" /> <Component id="163" /> <Component id="164" /> <Component id="295" /> <Component id="165" /> <Component id="166" /> <Component id="296" /> <Component id="167" /> <Component id="168" /> <Component id="169" /> <Component id="297" /> <Component id="170" /> <Component id="171" /> <Component id="172" /> <Component id="173" /> <Component id="298" /> <Component id="174" /> <Component id="175" /> <Component id="299" /> <Component id="176" /> <Component id="177" /> <Component id="178" /> <Component id="179" /> <Component id="274" /> <Component id="112" /> <Component id="113" /> <Component id="275" /> <Component id="114" /> <Component id="115" /> <Component id="276" /> <Component id="118" /> <Component id="119" /> <Component id="277" /> <Component id="120" /> <Component id="278" /> <Component id="121" /> <Component id="122" /> <Component id="123" /> <Component id="279" /> <Component id="124" /> <Component id="125" /> <Component id="126" /> <Component id="127" /> <Component id="280" /> <Component id="128" /> <Component id="129" /> <Component id="130" /> <Component id="131" /> <Component id="132" /> <Component id="133" /> <Component id="282" /> <Component id="135" /> <Component id="283" /> <Component id="136" /> <Component id="137" /> <Component id="138" /> <Component id="284" /> <Component id="141" /> <Component id="143" /> <Component id="286" /> <Component id="144" /> <Component id="145" /> <Component id="287" /> <Component id="146" /> <Component id="288" /> <Component id="147" /> <Component id="148" /> <Component id="151" /> <Component id="152" /> <Component id="291" /> <Component id="153" /> <Component id="154" /> <Component id="155" /> <Component id="156" /> <Component id="157" /> <Component id="158" /> <Component id="293" /> <Component id="162" /> <Component id="180" /> <Component id="181" /> <Component id="182" /> <Component id="183" /> <Component id="184" /> <Component id="185" /> <Component id="186" /> <Component id="303" /> <Component id="187" /> <Component id="188" /> <Component id="189" /> <Component id="190" /> <Component id="192" /> <Component id="193" /> <Component id="305" /> <Component id="195" /> <Component id="196" /> <Component id="197" /> <Component id="198" /> <Component id="199" /> <Component id="306" /> <Component id="200" /> <Component id="201" /> <Component id="202" /> <Component id="203" /> <Component id="204" /> <Component id="205" /> <Component id="308" /> <Component id="207" /> <Component id="209" /> <Component id="214" /> <Component id="215" /> <Component id="312" /> <Component id="313" /> <Component id="217" /> <Component id="218" /> <Component id="219" /> <Component id="220" /> <Component id="314" /> <Component id="222" /> <Component id="223" /> <Component id="224" /> <Component id="315" /> <Component id="225" /> <Component id="316" /> <Component id="226" /> <Component id="227" /> <Component id="228" /> <Component id="229" /> <Component id="317" /> <Component id="230" /> <Component id="231" /> <Component id="232" /> <Component id="233" /> <Component id="234" /> <Component id="235" /> <Component id="262" /> <Component id="206" /> <Component id="301" /> <Component id="302" /> <Component id="307" /> <Component id="221" /> <Component id="309" /> <Component id="210" /> <Component id="14" /> <Component id="8" /> <Component id="9" /> <Component id="11" /> <Component id="13" /> <Component id="16" /> <Component id="22" /> <Component id="12" /> <Component id="15" /> <Component id="21" /> <Component id="329" /> <Component id="334" /> <Component id="335" /> <Component id="337" /> <Component id="343" /> <Component id="345" /> <Component id="347" /> <Component id="338" /> <Component id="285" /> <Component id="357" /> <Component id="359" /> <Component id="364" /> <Component id="367" /> <Component id="374" /> <Component id="375" /> <Component id="376" /> <Component id="377" /> <Component id="333" /> <Component id="365" /> <Component id="562" /> <Component id="686" /> <Component id="687" /> <Component id="688" /> <Component id="689" /> <Component id="692" /> <Component id="5" /> <Component id="695" /> <Component id="7" /> <Component id="1134" /> <Component id="1141" /> <Component id="1142" /> <Component id="1143" /> <Component id="1144" /> <Component id="140" /> <Component id="149" /> <Component id="1145" /> <Component id="290" /> <Component id="289" /> <Component id="1152" /> <Component id="142" /> <Component id="1146" /> <Component id="1156" /> <Component id="1158" /> <Component id="1160" /> <Component id="1161" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="41" reactomeId="5218641" position="2019 217" bounds="1968 187 102 61" textPosition="1970 184" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableChemical id="42" reactomeId="113592" position="2062 298" bounds="2042 283 40 30" textPosition="2047 287" /> <org.gk.render.RenderableComplex id="43" reactomeId="5218636" position="2220 215" bounds="2172 185 97 61" textPosition="2179 182" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="44" reactomeId="29370" position="2178 292" bounds="2158 277 41 30" textPosition="2162 281" /> <org.gk.render.RenderableComplex id="45" reactomeId="210216" position="45 537" bounds="1 519 89 36" textPosition="3 519" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Integrin alphaVbeta3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="46" reactomeId="5218779" position="57 664" bounds="1 639 113 50" textPosition="4 639" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="47" reactomeId="192864" position="2266 295" bounds="2229 284 74 22" textPosition="2230 284"> <Properties> <displayName>HSP90AA1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="48" reactomeId="5218637" position="2411 216" bounds="2354 184 115 64" textPosition="2356 184" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="49" reactomeId="419057" position="2231 356" bounds="2184 345 95 22" textPosition="2185 345"> <Properties> <displayName>ROCK1,ROCK2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="51" reactomeId="3928564" position="2409 382" bounds="2352 364 114 36" textPosition="2362 364" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RHOA:GTP:ROCK1,ROCK2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="52" reactomeId="5228987" position="2583 384" bounds="2526 359 114 50" textPosition="2526 359" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RHOA:GTP:Mg2+:Activated ROCK1,ROCK2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="53" reactomeId="113592" position="2470 285" bounds="2450 270 40 30" textPosition="2455 274" /> <org.gk.render.RenderableChemical id="54" reactomeId="29370" position="2582 290" bounds="2562 275 41 30" textPosition="2566 279" /> <org.gk.render.RenderableComplex id="55" reactomeId="5218775" position="2631 218" bounds="2574 186 114 64" textPosition="2575 186" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="56" reactomeId="390932" position="144 689" bounds="121 678 47 22" textPosition="122 678"> <Properties> <displayName>PTK2B</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="57" reactomeId="5218787" position="69 790" bounds="4 765 131 50" textPosition="7 765" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2B</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="58" reactomeId="113592" position="134 836" bounds="114 821 40 30" textPosition="119 825" /> <org.gk.render.RenderableComplex id="59" reactomeId="5218778" position="264 970" bounds="208 938 113 64" textPosition="211 938" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="60" reactomeId="29370" position="136 910" bounds="116 895 41 30" textPosition="120 899" /> <org.gk.render.RenderableChemical id="61" reactomeId="113592" position="2689 284" bounds="2669 269 40 30" textPosition="2674 273" /> <org.gk.render.RenderableComplex id="62" reactomeId="5218757" position="2843 216" bounds="2786 186 115 61" textPosition="2788 183" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="63" reactomeId="29370" position="2789 289" bounds="2769 274 41 30" textPosition="2773 278" /> <org.gk.render.RenderableProtein id="64" reactomeId="210014" position="2888 291" bounds="2872 280 33 22" textPosition="2873 280"> <Properties> <displayName>PXN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="65" reactomeId="5218781" position="3045 216" bounds="2988 184 115 64" textPosition="2990 184" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="66" reactomeId="113592" position="3102 310" bounds="3082 295 40 30" textPosition="3087 299" /> <org.gk.render.RenderableChemical id="67" reactomeId="29370" position="3207 314" bounds="3187 299 41 30" textPosition="3191 303" /> <org.gk.render.RenderableComplex id="68" reactomeId="5218756" position="3278 217" bounds="3209 186 139 62" textPosition="3209 184" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="69" reactomeId="201625" position="2782 771" bounds="2751 760 62 22" textPosition="2758 760"> <Properties> <displayName>BCAR1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="70" reactomeId="5218790" position="2645 975" bounds="2581 936 128 78" textPosition="2581 950" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1:BCAR1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="71" reactomeId="113592" position="2723 906" bounds="2703 891 40 30" textPosition="2708 895" /> <org.gk.render.RenderableChemical id="72" reactomeId="29370" position="2839 901" bounds="2819 886 41 30" textPosition="2823 890" /> <org.gk.render.RenderableComplex id="73" reactomeId="5218762" position="2915 978" bounds="2858 939 115 78" textPosition="2860 939" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="74" reactomeId="5218759" position="3113 977" bounds="3020 935 187 85" textPosition="3021 938"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="75" reactomeId="2980677" position="3195 894" bounds="3179 883 33 22" textPosition="3179 883"> <Properties> <displayName>CRK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="76" reactomeId="5218765" position="3319 985" bounds="3235 953 169 64" textPosition="3246 953" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="77" reactomeId="5218785" position="3350 887" bounds="3303 870 95 34" textPosition="3305 868" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>DOCK180:ELMO1,ELMO2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="78" reactomeId="5218776" position="3528 985" bounds="3430 931 197 109" textPosition="3432 948" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="80" reactomeId="29438" position="3681 910" bounds="3661 895 41 30" textPosition="3666 899" /> <org.gk.render.RenderableChemical id="81" reactomeId="29420" position="3797 909" bounds="3776 894 42 30" textPosition="3781 898" /> <org.gk.render.RenderableComplex id="83" reactomeId="2029154" position="3850 829" bounds="3791 811 119 36" textPosition="3793 811" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>WAVE Regulatory Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="84" reactomeId="179838" position="3904 985" bounds="3867 970 74 30" textPosition="3870 974"> <Properties> <displayName>PI(3,4,5)P3</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="85" reactomeId="442574" position="3911 870" bounds="3885 859 52 22" textPosition="3886 859"> <Properties> <displayName>BAIAP2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="86" reactomeId="2029147" position="4012 979" bounds="3959 961 106 36" textPosition="3965 947" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>WRC:IRSp53/58:RAC1:GTP:PIP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="87" reactomeId="167050" position="641 929" bounds="620 918 42 22" textPosition="621 918"> <Properties> <displayName>SHC2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="88" reactomeId="4420171" position="522 982" bounds="475 964 94 36" textPosition="476 964" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:SHC2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="89" reactomeId="4420101" position="713 981" bounds="663 957 100 48" textPosition="668 955" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="90" reactomeId="4420125" position="776 925" bounds="742 913 68 24" textPosition="747 914"> <Properties> <displayName>SH2D2A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="91" reactomeId="4420137" position="906 982" bounds="844 957 125 50" textPosition="846 957" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="92" reactomeId="4420169" position="1108 965" bounds="1046 940 125 50" textPosition="1048 940" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="93" reactomeId="113592" position="1168 906" bounds="1148 891 40 30" textPosition="1153 895" /> <org.gk.render.RenderableComplex id="94" reactomeId="5218788" position="1318 977" bounds="1263 952 111 50" textPosition="1264 938" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="95" reactomeId="29370" position="1276 901" bounds="1256 886 41 30" textPosition="1260 890" /> <org.gk.render.RenderableProtein id="96" reactomeId="197705" position="1373 910" bounds="1357 899 32 22" textPosition="1357 899"> <Properties> <displayName>AXL</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="97" reactomeId="5357442" position="1490 963" bounds="1428 935 124 57" textPosition="1431 942" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="98" reactomeId="113592" position="1543 897" bounds="1523 882 40 30" textPosition="1528 886" /> <org.gk.render.RenderableChemical id="99" reactomeId="29370" position="1653 900" bounds="1633 885 41 30" textPosition="1637 889" /> <org.gk.render.RenderableComplex id="100" reactomeId="5357462" position="1704 972" bounds="1645 936 118 73" textPosition="1647 945" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="101" reactomeId="74693" position="1754 897" bounds="1737 886 34 22" textPosition="1737 886" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PI3K</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="102" reactomeId="5357453" position="1883 970" bounds="1808 938 151 64" textPosition="1809 952" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="103" reactomeId="5218777" position="2078 985" bounds="2031 961 94 48" textPosition="2033 959" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="104" reactomeId="113592" position="2332 899" bounds="2312 884 40 30" textPosition="2317 888" /> <org.gk.render.RenderableChemical id="105" reactomeId="179856" position="2319 980" bounds="2285 965 69 30" textPosition="2291 969"> <Properties> <displayName>PI(4,5)P2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="106" reactomeId="29370" position="2487 893" bounds="2467 878 41 30" textPosition="2471 882" /> <org.gk.render.RenderableEntitySet id="107" reactomeId="5357488" position="2210 972" bounds="2148 919 125 106" textPosition="2148 919"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="108" reactomeId="179838" position="2507 980" bounds="2470 965 74 30" textPosition="2473 969" /> <org.gk.render.RenderableEntitySet id="109" reactomeId="430172" position="4005 879" bounds="3971 867 68 25" textPosition="3972 868"> <Properties> <displayName>VAV1,2,3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="110" reactomeId="5340329" position="4138 982" bounds="4090 971 96 22" textPosition="4092 971" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PIP3:VAV1,2,3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="111" reactomeId="113592" position="4118 916" bounds="4098 901 40 30" textPosition="4103 905" /> <org.gk.render.RenderableComplex id="112" reactomeId="5218789" position="4258 983" bounds="4212 966 92 34" textPosition="4213 964" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-VAV family:PIP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="113" reactomeId="29370" position="4259 904" bounds="4239 889 41 30" textPosition="4243 893" /> <org.gk.render.RenderableComplex id="114" reactomeId="5218784" position="4715 985" bounds="4656 967 119 36" textPosition="4657 967" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-VAV family:PIP3:RAC1:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="115" reactomeId="29420" position="4687 911" bounds="4666 896 42 30" textPosition="4671 900"> <Properties> <displayName>GDP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="118" reactomeId="399856" position="4799 897" bounds="4748 886 103 22" textPosition="4750 886" bgColor="204 255 255"> <Properties> <displayName>PAK1,2,3 dimer</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="119" reactomeId="5357447" position="4897 987" bounds="4833 962 129 50" textPosition="4835 962" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="120" reactomeId="5357487" position="5047 988" bounds="4986 970 123 36" textPosition="4988 970" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-VAV family:PIP3:RAC1:GTP:PAK 1-3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="121" reactomeId="113592" position="5090 924" bounds="5070 909 40 30" textPosition="5075 913"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="122" reactomeId="399836" position="5268 986" bounds="5216 970 105 32" textPosition="5221 975"> <Properties> <displayName>p-S,T-PAK1,2,3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="123" reactomeId="29370" position="5211 916" bounds="5191 901 41 30" textPosition="5195 905" /> <org.gk.render.RenderableChemical id="124" reactomeId="113592" position="5466 927" bounds="5446 912 40 30" textPosition="5451 916" /> <org.gk.render.RenderableComplex id="125" reactomeId="5357454" position="5402 986" bounds="5335 968 135 36" textPosition="5338 968" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VE-cadherin-Catenin complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="126" reactomeId="5357459" position="5629 980" bounds="5569 955 120 50" textPosition="5574 955" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S665-VE-cadherin-Catenin complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="127" reactomeId="29370" position="5570 917" bounds="5550 902 41 30" textPosition="5554 906" /> <org.gk.render.RenderableProtein id="128" reactomeId="202210" position="5685 926" bounds="5661 915 48 22" textPosition="5662 915" /> <org.gk.render.RenderableComplex id="129" reactomeId="377179" position="5898 969" bounds="5858 958 80 22" textPosition="5862 958" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PDPK1:PIP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="130" reactomeId="2317329" position="5745 1000" bounds="5712 989 66 22" textPosition="5715 989" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>AKT:PIP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="131" reactomeId="113592" position="5726 897" bounds="5707 882 38 30" textPosition="5711 886" /> <org.gk.render.RenderableComplex id="132" reactomeId="2317310" position="5913 1003" bounds="5866 991 95 24" textPosition="5872 993" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S-AKT:PIP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="133" reactomeId="29370" position="5843 928" bounds="5824 913 39 30" textPosition="5827 917" /> <org.gk.render.RenderableComplex id="135" reactomeId="2317313" position="6081 989" bounds="6027 971 108 36" textPosition="6031 971" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S-AKT:PDPK1:PIP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="136" reactomeId="113592" position="6039 937" bounds="6019 922 40 30" textPosition="6024 926" /> <org.gk.render.RenderableChemical id="137" reactomeId="29370" position="5898 937" bounds="5878 922 41 30" textPosition="5882 926" /> <org.gk.render.RenderableEntitySet id="138" reactomeId="202074" position="5932 897" bounds="5897 886 71 22" textPosition="5906 879"> <Properties> <displayName>p-T,p-S-AKT</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="140" reactomeId="202128" position="6183 986" bounds="6141 969 84 35" textPosition="6148 968" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>eNOS:Caveolin-1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="141" reactomeId="202116" position="6326 983" bounds="6289 961 75 45" textPosition="6289 956" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>eNOS:Caveolin-1:CaM</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="142" reactomeId="202130" position="6454 986" bounds="6411 964 87 45" textPosition="6416 959" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>eNOS:Caveolin-1:CaM:HSP90</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="143" reactomeId="192864" position="6448 913" bounds="6409 902 78 22" textPosition="6412 902" /> <org.gk.render.RenderableProtein id="144" reactomeId="163510" position="6563 934" bounds="6543 923 41 22" textPosition="6546 916"> <Properties> <displayName>CAV1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="145" reactomeId="202105" position="6621 985" bounds="6582 968 79 35" textPosition="6584 967" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>eNOS:CaM:HSP90</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="146" reactomeId="198356" position="6634 858" bounds="6569 841 131 34" textPosition="6574 847"> <Properties> <displayName>p-T308,S473-AKT1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.2900763358778626" relativeY="0.9705882352941176" label="P" description="Thr" trackId="0" reactomeId="198329" /> <org.gk.render.RenderableFeature relativeX="0.5114503816793893" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="198374" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="147" reactomeId="202113" position="6761 987" bounds="6713 970 97 34" textPosition="6714 968" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>eNOS:CaM:HSP90:p-AKT1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="148" reactomeId="113592" position="6779 920" bounds="6759 905 40 30" textPosition="6764 909" /> <org.gk.render.RenderableComplex id="149" reactomeId="202121" position="6973 990" bounds="6910 972 127 36" textPosition="6911 972" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S1177-eNOS:CaM:HSP90:p-AKT1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="151" reactomeId="29870" position="6981 933" bounds="6961 918 41 30" textPosition="6965 922"> <Properties> <displayName>BH4</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="152" reactomeId="1497830" position="7096 901" bounds="7031 876 131 50" textPosition="7032 890" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="153" reactomeId="29368" position="6714 706" bounds="6697 691 34 30" textPosition="6701 695" /> <org.gk.render.RenderableChemical id="154" reactomeId="29468" position="6803 672" bounds="6778 657 50 30" textPosition="6783 661"> <Properties> <displayName>L-Arg</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="155" reactomeId="29364" position="6933 719" bounds="6904 704 59 30" textPosition="6908 708"> <Properties> <displayName>NADPH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="156" reactomeId="29366" position="6953 831" bounds="6923 816 60 30" textPosition="6928 820"> <Properties> <displayName>NADP+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="157" reactomeId="202124" position="6836 849" bounds="6819 834 35 30" textPosition="6823 838"> <Properties> <displayName>NO</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="158" reactomeId="29968" position="6777 840" bounds="6755 825 45 30" textPosition="6760 829"> <Properties> <displayName>L-Cit</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="159" reactomeId="5218791" position="7104 666" bounds="7056 655 96 22" textPosition="7074 641" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NOX2 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="160" reactomeId="5218774" position="7080 729" bounds="7030 711 100 36" textPosition="7030 697" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NOX2 complex:RAC1:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="162" reactomeId="70106" position="7017 857" bounds="7000 842 35 30" textPosition="7005 846" /> <org.gk.render.RenderableEntitySet id="163" reactomeId="381949" position="3327 296" bounds="3288 285 79 22" textPosition="3289 285"> <Properties> <displayName>NCK1,NCK2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="164" reactomeId="5218798" position="3458 215" bounds="3396 190 125 50" textPosition="3398 190" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="165" reactomeId="200917" position="3515 289" bounds="3500 278 31 22" textPosition="3500 278"> <Properties> <displayName>FYN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="166" reactomeId="5218786" position="3647 215" bounds="3584 190 126 50" textPosition="3587 190" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="167" reactomeId="113592" position="3693 291" bounds="3673 276 40 30" textPosition="3678 280" /> <org.gk.render.RenderableComplex id="168" reactomeId="5218795" position="3846 209" bounds="3787 177 119 64" textPosition="3789 177" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="169" reactomeId="29370" position="3812 295" bounds="3792 280 41 30" textPosition="3796 284" /> <org.gk.render.RenderableChemical id="170" reactomeId="113592" position="3875 298" bounds="3855 283 40 30" textPosition="3860 287" /> <org.gk.render.RenderableChemical id="171" reactomeId="29370" position="3999 298" bounds="3979 283 41 30" textPosition="3983 287" /> <org.gk.render.RenderableComplex id="172" reactomeId="5218780" position="4028 207" bounds="3965 175 126 64" textPosition="3968 175" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="173" reactomeId="425833" position="3930 399" bounds="3873 381 115 36" textPosition="3877 381"> <Properties> <displayName>Protein kinase A catalytic subunit</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="174" reactomeId="2685645" position="4047 345" bounds="4008 334 78 22" textPosition="4009 334" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PAK2 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="175" reactomeId="5218766" position="4175 207" bounds="4112 175 126 64" textPosition="4115 175" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="176" reactomeId="389331" position="4294 207" bounds="4247 195 95 24" textPosition="4256 197" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CDC42-GDP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="177" reactomeId="449518" position="4404 203" bounds="4365 192 78 22" textPosition="4366 192" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CDC42:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="178" reactomeId="29438" position="4288 279" bounds="4268 264 41 30" textPosition="4273 268"> <Properties> <displayName>GTP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="179" reactomeId="29420" position="4408 283" bounds="4387 268 42 30" textPosition="4392 272" /> <org.gk.render.RenderableComplex id="180" reactomeId="5218782" position="4525 220" bounds="4461 188 129 64" textPosition="4462 188" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="181" reactomeId="113592" position="4595 296" bounds="4575 281 40 30" textPosition="4580 285" /> <org.gk.render.RenderableChemical id="182" reactomeId="29370" position="4649 294" bounds="4629 279 41 30" textPosition="4633 283" /> <org.gk.render.RenderableComplex id="183" reactomeId="5218792" position="4724 223" bounds="4660 191 129 64" textPosition="4661 191" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="184" reactomeId="113592" position="4778 308" bounds="4758 293 40 30" textPosition="4763 297" /> <org.gk.render.RenderableComplex id="185" reactomeId="5218793" position="4928 220" bounds="4864 188 129 64" textPosition="4865 188" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="186" reactomeId="29370" position="4886 313" bounds="4866 298 41 30" textPosition="4870 302" /> <org.gk.render.RenderableChemical id="187" reactomeId="113592" position="4842 406" bounds="4822 391 40 30" textPosition="4827 395" /> <org.gk.render.RenderableComplex id="188" reactomeId="189828" position="4849 499" bounds="4793 481 112 36" textPosition="4795 481" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MAP kinase p38 (Mg2+ cofactor)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="189" reactomeId="170993" position="5021 495" bounds="4954 476 135 39" textPosition="4955 479" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Phospho-MAP kinase p38 (Mg2+ cofactor)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="190" reactomeId="29370" position="5007 400" bounds="4987 385 41 30" textPosition="4991 389" /> <org.gk.render.RenderableEntitySet id="192" reactomeId="187699" position="5150 473" bounds="5099 462 103 22" textPosition="5101 462"> <Properties> <displayName>MAPKAP kinase</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="193" reactomeId="187726" position="5317 459" bounds="5259 428 117 63" textPosition="5260 434"> <Properties> <displayName>p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="195" reactomeId="113592" position="5529 522" bounds="5509 507 40 30" textPosition="5514 511" /> <org.gk.render.RenderableComplex id="196" reactomeId="5218769" position="5453 464" bounds="5396 446 115 36" textPosition="5400 446" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>HSP27 oligomer:F-actin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="197" reactomeId="201877" position="5662 413" bounds="5637 402 51 22" textPosition="5638 402"> <Properties> <displayName>F-actin</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableProtein id="198" reactomeId="5218697" position="5706 465" bounds="5654 441 104 48" textPosition="5656 447"> <Properties> <displayName>p-S15,S78,S82-HSP27</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.3269230769230769" relativeY="1.0" label="P" description="Ser" trackId="0" reactomeId="5218699" /> <org.gk.render.RenderableFeature relativeX="0.3173076923076923" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="5218708" /> <org.gk.render.RenderableFeature relativeX="0.7115384615384616" relativeY="1.0" label="P" description="Ser" trackId="0" reactomeId="5218726" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="199" reactomeId="29370" position="5664 517" bounds="5644 502 41 30" textPosition="5648 506" /> <org.gk.render.RenderableProtein id="200" reactomeId="202320" position="4979 309" bounds="4956 298 47 22" textPosition="4957 298"> <Properties> <displayName>PLCG1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="201" reactomeId="4420203" position="5101 214" bounds="5043 190 116 48" textPosition="5043 188" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="202" reactomeId="113592" position="5168 263" bounds="5148 248 40 30" textPosition="5153 252" /> <org.gk.render.RenderableComplex id="203" reactomeId="4420110" position="5333 213" bounds="5270 188 126 50" textPosition="5273 188" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="204" reactomeId="29370" position="5262 275" bounds="5242 260 41 30" textPosition="5246 264" /> <org.gk.render.RenderableProtein id="205" reactomeId="354153" position="5217 333" bounds="5194 322 46 22" textPosition="5195 322" /> <org.gk.render.RenderableProtein id="206" reactomeId="167679" position="5503 214" bounds="5459 198 89 33" textPosition="5465 203"> <Properties> <displayName>p-4Y-PLCG1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.651685393258427" relativeY="1.0" label="P" description="Tyr" trackId="0" reactomeId="167675" /> <org.gk.render.RenderableFeature relativeX="0.3146067415730337" relativeY="1.0" label="P" description="Tyr" trackId="0" reactomeId="191478" /> <org.gk.render.RenderableFeature relativeX="0.29213483146067415" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="191469" /> <org.gk.render.RenderableFeature relativeX="0.6404494382022472" relativeY="0.0" label="P" description="Tyr" trackId="0" reactomeId="213441" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="207" reactomeId="29356" position="5633 256" bounds="5612 241 43 30" textPosition="5616 245"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="209" reactomeId="114520" position="5787 255" bounds="5750 240 75 30" textPosition="5757 244"> <Properties> <displayName>I(1,4,5)P3</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="210" reactomeId="179856" position="5599 216" bounds="5565 201 69 30" textPosition="5571 205" /> <org.gk.render.RenderableComplex id="212" reactomeId="169696" position="6049 315" bounds="5996 297 106 36" textPosition="6002 297" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ITPR:I(1,4,5)P3 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="213" reactomeId="111875" position="5895 388" bounds="5870 373 50 30" textPosition="5875 377" /> <org.gk.render.RenderableChemical id="214" reactomeId="74016" position="6145 398" bounds="6120 383 50 30" textPosition="6125 387"> <Properties> <displayName>Ca2+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableCompartment id="215" reactomeId="17957" position="5934 378" bounds="5773 309 323 138" textPosition="5795 401" bgColor="250 240 240" lineColor="255 153 102" insets="5782 318 305 119"> <Properties> <displayName>endoplasmic reticulum lumen</displayName> </Properties> <Components> <Component id="212" /> <Component id="311" /> <Component id="213" /> <Component id="310" /> <Component id="1157" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="217" reactomeId="113592" position="6354 262" bounds="6334 247 40 30" textPosition="6339 251" /> <org.gk.render.RenderableEntitySet id="218" reactomeId="5218761" position="6351 340" bounds="6294 322 114 36" textPosition="6297 322"> <Properties> <displayName>PKCA,PKCB,PKCD,PKCZ</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="219" reactomeId="5218754" position="6523 340" bounds="6458 322 131 36" textPosition="6468 322"> <Properties> <displayName>p-PKCA,p-PKCB,p-PKCZ,p-PKCD</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="220" reactomeId="29370" position="6508 260" bounds="6488 245 41 30" textPosition="6492 249"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="221" reactomeId="61459" position="6433 215" bounds="6409 204 48 22" textPosition="6410 204"> <Properties> <displayName>PDPK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="222" reactomeId="113592" position="6612 288" bounds="6592 273 40 30" textPosition="6597 277" /> <org.gk.render.RenderableChemical id="223" reactomeId="29370" position="6743 290" bounds="6723 275 41 30" textPosition="6727 279" /> <org.gk.render.RenderableEntitySet id="224" reactomeId="5218758" position="6762 339" bounds="6739 328 47 22" textPosition="6741 328"> <Properties> <displayName>p-PKC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="225" reactomeId="5218773" position="7085 381" bounds="7034 363 103 36" textPosition="7046 363" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>DAG:active PKC:Ca+2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="226" reactomeId="113592" position="6548 413" bounds="6528 398 40 30" textPosition="6533 402" /> <org.gk.render.RenderableProtein id="227" reactomeId="391267" position="6545 477" bounds="6521 466 49 22" textPosition="6522 466"> <Properties> <displayName>SPHK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="228" reactomeId="5218716" position="6714 482" bounds="6665 467 99 31" textPosition="6668 471"> <Properties> <displayName>p-S225-SPHK1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.5252525252525253" relativeY="1.0" label="P" description="Ser" trackId="0" reactomeId="5218714" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="229" reactomeId="29370" position="6710 410" bounds="6690 395 41 30" textPosition="6694 399" /> <org.gk.render.RenderableChemical id="230" reactomeId="113592" position="6959 460" bounds="6939 445 40 30" textPosition="6944 449" /> <org.gk.render.RenderableComplex id="231" reactomeId="5218802" position="7077 441" bounds="7033 424 89 34" textPosition="7035 422" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RASA1:p21 RAS:GTP:SPG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="232" reactomeId="5218688" position="6837 517" bounds="6818 502 38 30" textPosition="6822 506"> <Properties> <displayName>S1P</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="233" reactomeId="186833" position="6853 548" bounds="6829 537 49 22" textPosition="6829 537"> <Properties> <displayName>RASA1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="234" reactomeId="29370" position="6928 570" bounds="6908 555 41 30" textPosition="6912 559" /> <org.gk.render.RenderableComplex id="235" reactomeId="109783" position="7077 584" bounds="7033 573 89 22" textPosition="7034 573" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p21 RAS:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="325" reactomeId="195376" position="250 36" bounds="206 23 89 27" textPosition="212 25" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>VEGF dimer</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="329" reactomeId="199453" position="5709 807" bounds="5664 789 91 36" textPosition="5665 789" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>AKT:PIP3:THEM4/TRIB3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="333" reactomeId="442641" position="3820 982" bounds="3786 971 69 22" textPosition="3787 971" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="334" reactomeId="5226920" position="6016 512" bounds="5962 487 109 50" textPosition="5966 487" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="335" reactomeId="5673001" position="6752 608" bounds="6676 574 152 69" textPosition="6693 586"> <Properties> <displayName>RAF/MAP kinase cascade</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemical id="338" reactomeId="5693375" position="6888 772" bounds="6862 757 52 30" textPosition="6865 761"> <Properties> <displayName>ADMA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="343" reactomeId="354153" position="989 883" bounds="966 872 46 22" textPosition="967 872" /> <org.gk.render.RenderableChemical id="345" reactomeId="112275" position="7085 248" bounds="7061 233 49 30" textPosition="7065 237"> <Properties> <displayName>DAGs</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="347" reactomeId="74016" position="7009 244" bounds="6984 229 50 30" textPosition="6989 233" /> <org.gk.render.RenderableComplex id="357" reactomeId="74294" position="6239 709" bounds="6178 696 123 26" textPosition="6189 700" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CALM1:4xCa2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="359" reactomeId="5218641" position="238 874" bounds="189 843 99 63" textPosition="189 842" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="364" reactomeId="5218641" position="4180 865" bounds="4129 835 102 61" textPosition="4131 832" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="365" reactomeId="5674631" position="3675 985" bounds="3640 974 70 22" textPosition="3640 974" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RAC1:GDP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="367" reactomeId="442641" position="7043 629" bounds="7009 618 69 22" textPosition="7010 618" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RAC1:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="375" reactomeId="113592" position="5150 561" bounds="5130 546 40 30" textPosition="5135 550" /> <org.gk.render.RenderableChemical id="376" reactomeId="29370" position="5326 561" bounds="5306 546 41 30" textPosition="5310 550" /> <org.gk.render.RenderableEntity id="377" reactomeId="8939797" position="4346 311" bounds="4303 300 87 22" textPosition="4313 293"> <Properties> <displayName>Unknown GEF</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableComplex id="562" reactomeId="8951587" position="4500 985" bounds="4438 967 125 36" textPosition="4442 967" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-VAV family:PIP3:RAC1:GDP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="686" reactomeId="29438" position="4513 927" bounds="4493 912 41 30" textPosition="4498 916" /> <org.gk.render.RenderableComplex id="688" reactomeId="5665993" position="2237 417" bounds="2202 406 70 22" textPosition="2202 406" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RHOA:GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="689" reactomeId="9016707" position="6209 336" bounds="6180 326 58 21" textPosition="6184 326"> <Properties> <displayName>CALM1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="690" reactomeId="352327" position="7174 768" bounds="7157 753 34 30" textPosition="7161 757"> <Properties> <displayName>O2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="691" reactomeId="3299686" position="7172 812" bounds="7154 795 37 35" textPosition="7156 801"> <Properties> <displayName>O2.-</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableCompartment id="692" reactomeId="7660" position="476 634" bounds="328 526 296 216" textPosition="346 688" bgColor="250 240 240" lineColor="255 153 102" insets="342 538 269 190"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="694" /> <Component id="693" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="694" reactomeId="8962576" position="400 657" bounds="363 632 74 51" textPosition="376 659"> <Properties> <displayName>AAMP gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="695" reactomeId="9674636" position="685 635" bounds="664 624 42 22" textPosition="666 617"> <Properties> <displayName>AAMP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="696" reactomeId="195364" position="481 22" bounds="439 11 85 22" textPosition="439 11" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="959" reactomeId="4420158" position="727 135" bounds="690 118 74 35" textPosition="692 117" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VEGFA-165 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1091" reactomeId="9679456" position="758 20" bounds="722 4 73 33" textPosition="727 3" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>VEGFA inhibitors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1092" reactomeId="9679453" position="849 109" bounds="796 84 106 50" textPosition="804 84" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>VEGFA-165 dimer:VEGFA inhibitors</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1134" reactomeId="113592" position="897 281" bounds="877 266 40 30" textPosition="882 270" /> <org.gk.render.RenderableChemical id="1141" reactomeId="29370" position="1014 282" bounds="994 267 41 30" textPosition="998 271" /> <org.gk.render.RenderableComplex id="1142" reactomeId="9755778" position="5983 837" bounds="5946 826 75 23" textPosition="5947 827" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>N:M:PDPK1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1143" reactomeId="9833482" position="6532 587" bounds="6470 557 125 60" textPosition="6481 565"> <Properties> <displayName>PKR-mediated signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemical id="1145" reactomeId="29370" position="6870 917" bounds="6850 902 41 31" textPosition="6854 906" /> <org.gk.render.RenderableChemical id="1146" reactomeId="29356" position="6895 851" bounds="6874 836 43 31" textPosition="6878 840" /> <org.gk.render.RenderableChemical id="1152" reactomeId="70106" position="6911 944" bounds="6894 929 35 30" textPosition="6899 933" /> <org.gk.render.RenderableChemical id="1156" reactomeId="70106" position="6744 669" bounds="6727 654 35 30" textPosition="6732 658" /> <org.gk.render.RenderableEntitySet id="1157" reactomeId="5622009" position="5874 313" bounds="5840 293 69 40" textPosition="5842 295"> <Properties> <displayName>ITPR tetramers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="1158" reactomeId="114519" position="5784 215" bounds="5763 200 43 31" textPosition="5767 204"> <Properties> <displayName>DAG</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1160" reactomeId="70106" position="5705 262" bounds="5688 247 35 30" textPosition="5693 251"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1161" reactomeId="9980228" position="5808 846" bounds="5765 835 86 23" textPosition="5765 836" bgColor="204 255 255" hideComponents="true" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="17" reactomeId="195378" points="121 35, 166 35, 200 35" position="166 35" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2" stoichiometry="2" /> </Inputs> <Outputs> <Output id="325" /> </Outputs> <Properties> <displayName>Homodimerization of VEGF proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="18" reactomeId="194311" points="127 171, 128 171, 161 196" position="128 171" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="101 166" /> <Input id="14" stoichiometry="2" points="69 201" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Properties> <displayName>VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="19" reactomeId="194310" points="625 175, 625 175, 581 198" position="625 175" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="580 129" /> <Input id="7" stoichiometry="2" points="675 200" /> </Inputs> <Outputs> <Output id="8" /> </Outputs> <Properties> <displayName>VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="20" reactomeId="194308" points="357 177, 359 177, 383 194" position="359 177" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9" stoichiometry="2" points="330 200" /> <Input id="10" points="328 167" /> </Inputs> <Outputs> <Output id="11" /> </Outputs> <Properties> <displayName>VEGF-C,D bind to VEGFR3 leading to receptor dimerization</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="21" reactomeId="195408" points="99 410, 98 446, 73 462" position="98 446" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15" stoichiometry="2" points="65 394" /> <Input id="7" stoichiometry="2" points="666 224" /> </Inputs> <Outputs> <Output id="12" /> </Outputs> <Properties> <displayName>NRP-1 forms a ternary complex with VEGF165 and VEGFR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="22" reactomeId="195418" points="101 257, 128 285, 85 304" position="128 285" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="16" stoichiometry="2" points="52 267" /> <Input id="14" stoichiometry="2" points="65 235" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> <Properties> <displayName>NRP-2 associates with VEGFR1 forming complexes on cell surface</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="23" points="328 143, 517 110" position="422 126" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="10" /> </Inputs> <Outputs> <Output id="6" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="24" points="517 106, 115 136" position="316 121" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="6" /> </Inputs> <Outputs> <Output id="4" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="237" reactomeId="4420117" points="944 216, 978 216, 1003 216" position="978 216" lineWidth="1.0"> <Inputs> <Input id="26" points="905 216" /> <Input id="7" points="731 226, 829 268" /> <Input id="1134" stoichiometry="12" points="907 263" /> </Inputs> <Outputs> <Output id="27" points="1025 216" /> <Output id="1141" stoichiometry="12" points="1011 264" /> </Outputs> <Catalysts> <Catalyst id="26" points="893 196, 978 160" /> </Catalysts> <Properties> <displayName>VEGFR2 autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="238" reactomeId="4420099" points="1153 217, 1177 217, 1207 217" position="1177 217" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="29" points="1125 253" /> <Input id="27" points="1131 217" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> <Properties> <displayName>p-6Y-VEGFR2 binds SHB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="239" reactomeId="4420128" points="1333 216, 1359 216, 1386 216" position="1359 216" lineWidth="1.0"> <Inputs> <Input id="30" points="1311 216" /> <Input id="31" points="1319 253" /> </Inputs> <Outputs> <Output id="32" points="1416 216" /> <Output id="33" points="1427 261" /> </Outputs> <Catalysts> <Catalyst id="34" points="1359 303" /> </Catalysts> <Properties> <displayName>SRC-1 phosphorylates SHB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="240" reactomeId="4420083" points="1545 216, 1570 216, 1599 216" position="1570 216" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="32" points="1523 216" /> <Input id="35" points="1530 269" /> </Inputs> <Outputs> <Output id="36" /> </Outputs> <Properties> <displayName>PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="241" reactomeId="5218642" points="1711 215, 1735 215, 1759 215" position="1735 215" lineWidth="1.0"> <Inputs> <Input id="37" points="1685 261" /> <Input id="36" points="1690 215" /> </Inputs> <Outputs> <Output id="38" points="1778 215" /> <Output id="39" points="1789 261" /> </Outputs> <Catalysts> <Catalyst id="36" points="1643 189, 1643 164, 1735 164" /> </Catalysts> <Properties> <displayName>PTK2 autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="242" reactomeId="5218645" points="1912 216, 1932 216, 1965 216" position="1932 216" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="38" points="1898 216" /> <Input id="34" points="1385 317, 1843 317" /> </Inputs> <Outputs> <Output id="41" /> </Outputs> <Properties> <displayName>SRC-1 binds p-Y397-PTK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="243" reactomeId="5218640" points="2092 215, 2118 215, 2142 215" position="2118 215" lineWidth="1.0"> <Inputs> <Input id="42" stoichiometry="5" points="2067 280" /> <Input id="41" points="2073 215" /> </Inputs> <Outputs> <Output id="43" points="2169 215" /> <Output id="44" stoichiometry="5" points="2170 274" /> </Outputs> <Catalysts> <Catalyst id="41" points="2017 184, 2017 157, 2118 157" /> </Catalysts> <Properties> <displayName>SRC-1 phosphorylates p-Y397-PTK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="244" reactomeId="5218818" points="74 580, 46 604, 52 636" position="46 604" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="45" points="57 558" /> <Input id="27" points="1070 243, 1041 322" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> <Properties> <displayName>Integrin alphaVbeta3 binds p-6Y-VEGFR2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="245" reactomeId="5218643" points="2297 215, 2321 215, 2351 215" position="2321 215" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="47" points="2270 281" /> <Input id="43" points="2272 215" /> </Inputs> <Outputs> <Output id="48" /> </Outputs> <Properties> <displayName>HSP90AA1 binds p-6Y-VEGFR2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="246" reactomeId="3928647" points="2315 383, 2315 382, 2349 382" position="2315 382" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="688" points="2262 403" /> <Input id="49" points="2265 373" /> </Inputs> <Outputs> <Output id="51" /> </Outputs> <Activators> <Activator id="48" points="2392 251" /> </Activators> <Properties> <displayName>RHOA:GTP:Mg2+ binds ROCK1,ROCK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="247" reactomeId="5228992" points="2469 382, 2497 382, 2523 382" position="2497 382" lineWidth="1.0"> <Inputs> <Input id="51" /> </Inputs> <Outputs> <Output id="52" /> </Outputs> <Properties> <displayName>ROCK1,ROCK2 are activated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="248" reactomeId="5218826" points="2500 216, 2526 216, 2550 216" position="2526 216" lineWidth="1.0"> <Inputs> <Input id="53" points="2476 267" /> <Input id="48" points="2472 216" /> </Inputs> <Outputs> <Output id="54" points="2575 272" /> <Output id="55" points="2571 216" /> </Outputs> <Catalysts> <Catalyst id="52" points="2562 356, 2526 314" /> </Catalysts> <Properties> <displayName>Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="249" reactomeId="5218836" points="79 718, 51 739, 60 762" position="51 739" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="46" points="67 692" /> <Input id="56" points="118 699" /> </Inputs> <Outputs> <Output id="57" /> </Outputs> <Properties> <displayName>PTK2beta binds alphaVbeta3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="250" reactomeId="5218830" points="34 856, 34 902, 34 942" position="34 902" lineWidth="1.0"> <Inputs> <Input id="58" points="111 840" /> <Input id="57" points="55 818" /> </Inputs> <Outputs> <Output id="59" points="205 963" /> <Output id="60" points="113 916" /> </Outputs> <Catalysts> <Catalyst id="359" points="186 880" /> </Catalysts> <Properties> <displayName>SRC-1 phosphorylates PTK2-beta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="251" reactomeId="5218851" points="2711 216, 2734 216, 2755 216" position="2734 216" lineWidth="1.0"> <Inputs> <Input id="61" points="2693 266" /> <Input id="55" points="2691 216" /> </Inputs> <Outputs> <Output id="62" points="2783 216" /> <Output id="63" points="2782 271" /> </Outputs> <Catalysts> <Catalyst id="59" points="324 957, 2734 413" /> </Catalysts> <Properties> <displayName>p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="252" reactomeId="5218838" points="2933 216, 2958 216, 2985 216" position="2958 216" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="62" points="2904 216" /> <Input id="64" points="2894 277" /> </Inputs> <Outputs> <Output id="65" /> </Outputs> <Properties> <displayName>PXN binds p-6Y,S732-PTK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="253" reactomeId="5218809" points="3130 215, 3156 215, 3179 215" position="3156 215" lineWidth="1.0"> <Inputs> <Input id="66" stoichiometry="2" points="3106 292" /> <Input id="65" points="3106 215" /> </Inputs> <Outputs> <Output id="67" stoichiometry="2" points="3202 296" /> <Output id="68" points="3206 215" /> </Outputs> <Catalysts> <Catalyst id="65" points="3045 181, 3045 153, 3155 153" /> </Catalysts> <Properties> <displayName>PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="254" reactomeId="5218855" points="2711 830, 2698 865, 2663 933" position="2698 865" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="69" points="2768 785" /> <Input id="62" points="2836 250" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> <Properties> <displayName>BCAR1 binds p-7Y-PTK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="255" reactomeId="5218828" points="2762 977, 2789 977, 2816 977" position="2789 977" lineWidth="1.0"> <Inputs> <Input id="71" stoichiometry="12" points="2731 924" /> <Input id="70" points="2712 976" /> </Inputs> <Outputs> <Output id="72" stoichiometry="12" points="2834 919" /> <Output id="73" points="2855 977" /> </Outputs> <Catalysts> <Catalyst id="70" points="2653 1017, 2663 1056, 2788 1055" /> </Catalysts> <Properties> <displayName>PTK2/SRC-1 phosphorylates BCAR1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="256" reactomeId="5218822" points="3222 919, 3251 921, 3285 950" position="3251 921" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="74" points="3192 929" /> <Input id="75" points="3206 908" /> </Inputs> <Outputs> <Output id="76" /> </Outputs> <Properties> <displayName>CRK binds BCAR1 and or PXN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="257" points="3271 251, 3122 929" position="3196 590" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="68" /> </Inputs> <Outputs> <Output id="74" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="258" points="2976 977, 3014 977" position="2995 977" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="73" /> </Inputs> <Outputs> <Output id="74" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="259" reactomeId="5218811" points="3378 931, 3406 931, 3427 941" position="3406 931" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="77" points="3360 907" /> <Input id="76" points="3353 950" /> </Inputs> <Outputs> <Output id="78" /> </Outputs> <Properties> <displayName>DOCK180:ELMO binds CRK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="260" reactomeId="5218839" points="3708 952, 3734 952, 3757 952" position="3734 952" lineWidth="1.0"> <Inputs> <Input id="80" points="3690 928" /> <Input id="365" points="3686 971" /> </Inputs> <Outputs> <Output id="81" points="3783 927" /> <Output id="333" points="3796 968" /> </Outputs> <Catalysts> <Catalyst id="78" points="3605 928, 3694 869" /> </Catalysts> <Properties> <displayName>DOCK180:ELMO exchanges GTP for GDP, activating RAC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="261" reactomeId="2029465" points="3887 926, 3925 925, 3983 958" position="3925 925" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="85" points="3906 884" /> <Input id="83" points="3856 850" /> <Input id="84" points="3899 967" /> <Input id="333" points="3833 968" /> </Inputs> <Outputs> <Output id="86" /> </Outputs> <Properties> <displayName>RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="262" reactomeId="4420107" points="630 981, 606 981, 572 981" position="606 981" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="87" points="638 943" /> <Input id="89" points="660 981" /> </Inputs> <Outputs> <Output id="88" /> </Outputs> <Properties> <displayName>p-6Y-VEGFR2 binds SHC-transforming protein 2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="263" reactomeId="4420143" points="784 981, 804 981, 841 981" position="804 981" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="90" points="777 940" /> <Input id="89" points="766 981" /> </Inputs> <Outputs> <Output id="91" /> </Outputs> <Properties> <displayName>p-6Y-VEGFR2 binds SH2D2A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="264" reactomeId="4420140" points="998 952, 1014 984, 1043 977" position="1014 984" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="91" points="972 961" /> <Input id="343" points="990 897" /> </Inputs> <Outputs> <Output id="92" /> </Outputs> <Properties> <displayName>SRC1-1 binds SH2D2A and is recruited to VEGFR2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="265" reactomeId="4420206" points="1198 948, 1217 972, 1235 948" position="1217 972" lineWidth="1.0"> <Inputs> <Input id="93" points="1178 924" /> <Input id="92" points="1174 953" /> </Inputs> <Outputs> <Output id="94" points="1260 957" /> <Output id="95" points="1262 919" /> </Outputs> <Catalysts> <Catalyst id="92" points="1107 993, 1107 1022, 1216 1022" /> </Catalysts> <Properties> <displayName>Phosphorylation of SRC-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="266" reactomeId="5357432" points="1399 976, 1404 946, 1425 950" position="1404 946" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="94" points="1377 976" /> <Input id="96" points="1377 924" /> </Inputs> <Outputs> <Output id="97" /> </Outputs> <Properties> <displayName>AXL binds SRC-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="267" reactomeId="5357429" points="1581 944, 1598 974, 1617 944" position="1598 974" lineWidth="1.0"> <Inputs> <Input id="97" points="1555 950" /> <Input id="98" stoichiometry="2" points="1555 915" /> </Inputs> <Outputs> <Output id="99" stoichiometry="2" points="1640 918" /> <Output id="100" points="1642 953" /> </Outputs> <Catalysts> <Catalyst id="97" points="1492 995, 1495 1021, 1597 1021" /> </Catalysts> <Properties> <displayName>AXL autophosphorylates on Y779 and Y821</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="268" reactomeId="5357479" points="1779 931, 1787 976, 1805 974" position="1787 976" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="101" points="1762 911" /> <Input id="100" points="1766 939" /> </Inputs> <Outputs> <Output id="102" /> </Outputs> <Properties> <displayName>p-AXL binds PI3K</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="269" reactomeId="5218852" points="2004 1002, 2020 939, 2047 958" position="2020 939" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="101" points="1774 899, 2001 930" /> <Input id="89" points="713 1008, 713 1035, 1788 1033" /> </Inputs> <Outputs> <Output id="103" /> </Outputs> <Properties> <displayName>p-6Y-VEGFR2 binds PI3K</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="270" reactomeId="5218819" points="2381 980, 2410 980, 2438 980" position="2410 980" lineWidth="1.0"> <Inputs> <Input id="104" points="2341 917" /> <Input id="105" points="2357 980" /> </Inputs> <Outputs> <Output id="106" points="2478 911" /> <Output id="108" points="2467 980" /> </Outputs> <Catalysts> <Catalyst id="107" points="2208 1031, 2208 1053, 2410 1052" /> </Catalysts> <Properties> <displayName>VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="271" points="1931 935, 2018 880, 2142 942" position="2018 880" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="102" /> </Inputs> <Outputs> <Output id="107" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="272" points="2094 1012, 2123 1052, 2152 1031" position="2123 1052" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="103" /> </Inputs> <Outputs> <Output id="107" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="273" reactomeId="434637" points="3994 924, 4045 925, 4120 968" position="4045 925" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="109" points="4001 898" /> <Input id="84" points="3926 967" /> </Inputs> <Outputs> <Output id="110" /> </Outputs> <Properties> <displayName>PI(3,4,5)P3 binds VAV1,2,3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="274" reactomeId="5218820" points="4163 939, 4179 938, 4200 938" position="4179 938" lineWidth="1.0"> <Inputs> <Input id="110" points="4144 968" /> <Input id="111" points="4141 926" /> </Inputs> <Outputs> <Output id="112" points="4236 963" /> <Output id="113" points="4236 915" /> </Outputs> <Catalysts> <Catalyst id="364" points="4179 899" /> </Catalysts> <Properties> <displayName>Src kinases phosphorylate VAV</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="275" reactomeId="5218850" points="4587 951, 4617 950, 4646 950" position="4617 950" lineWidth="1.0"> <Inputs> <Input id="562" points="4546 964" /> <Input id="686" points="4537 933" /> </Inputs> <Outputs> <Output id="114" points="4679 964" /> <Output id="115" points="4671 929" /> </Outputs> <Catalysts> <Catalyst id="562" points="4566 993, 4617 1001" /> </Catalysts> <Properties> <displayName>VAV exchanges GTP for GDP on RAC1, activating it</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="276" reactomeId="5357483" points="4806 942, 4828 942, 4858 959" position="4828 942" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="114" stoichiometry="2" points="4753 964" /> <Input id="118" points="4800 914" /> </Inputs> <Outputs> <Output id="119" /> </Outputs> <Properties> <displayName>RAC1 binds PAK1-3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="277" reactomeId="5357445" points="4940 959, 4976 942, 5019 967" position="4976 942" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="119" /> </Inputs> <Outputs> <Output id="120" stoichiometry="2" /> </Outputs> <Properties> <displayName>PAK1-3 dimer disassociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="278" reactomeId="5357472" points="5138 985, 5162 950, 5190 985" position="5162 950" lineWidth="1.0"> <Inputs> <Input id="121" stoichiometry="2" points="5101 942" /> <Input id="120" points="5112 985" /> </Inputs> <Outputs> <Output id="122" points="5210 985" /> <Output id="114" points="4748 1006, 4795 1028, 5161 1028" /> <Output id="123" stoichiometry="2" points="5206 934" /> </Outputs> <Catalysts> <Catalyst id="118" points="4857 897, 5162 897" /> </Catalysts> <Properties> <displayName>PAK1-3 autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="279" reactomeId="5357477" points="5494 984, 5516 955, 5541 984" position="5516 955" lineWidth="1.0"> <Inputs> <Input id="124" points="5473 945" /> <Input id="125" points="5473 984" /> </Inputs> <Outputs> <Output id="126" points="5566 982" /> <Output id="127" points="5563 935" /> </Outputs> <Catalysts> <Catalyst id="122" points="5267 1008, 5267 1022, 5515 1022" /> </Catalysts> <Properties> <displayName>PAK1-3 phosphorylates VE-cadherin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="280" reactomeId="2316429" points="5715 965, 5736 964, 5855 967" position="5736 964" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="128" points="5693 940" /> <Input id="84" points="3944 995, 4152 1054, 5697 1042" /> </Inputs> <Outputs> <Output id="129" /> </Outputs> <Properties> <displayName>PIP3 recruits PDPK1 to the membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="281" reactomeId="198640" points="5794 999, 5821 999, 5843 999" position="5821 999" lineWidth="1.0"> <Inputs> <Input id="130" points="5781 999" /> <Input id="131" points="5736 915" /> </Inputs> <Outputs> <Output id="132" points="5863 1000" /> <Output id="133" points="5843 946" /> </Outputs> <Catalysts> <Catalyst id="1161" points="5808 861" /> </Catalysts> <Inhibitors> <Inhibitor id="329" points="5719 828" /> </Inhibitors> <Properties> <displayName>mTORC2 phosphorylates AKT at S473</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="282" reactomeId="2317314" points="5965 984, 5984 989, 6024 989" position="5984 989" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="132" points="5945 988" /> <Input id="129" points="5941 977" /> </Inputs> <Outputs> <Output id="135" /> </Outputs> <Properties> <displayName>AKT binds PDPK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="283" reactomeId="198270" points="6011 972, 5985 972, 5963 972" position="5985 972" lineWidth="1.0"> <Inputs> <Input id="136" points="6027 955" /> <Input id="135" points="6024 975" /> </Inputs> <Outputs> <Output id="129" points="5941 970" /> <Output id="137" points="5922 948" /> <Output id="138" points="5936 914" /> </Outputs> <Catalysts> <Catalyst id="135" points="6080 968, 6080 900, 6009 922" /> </Catalysts> <Inhibitors> <Inhibitor id="1142" points="5983 852" /> </Inhibitors> <Properties> <displayName>PDPK1 phosphorylates AKT at T308</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="284" reactomeId="202110" points="6245 983, 6264 983, 6286 983" position="6264 983" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="140" points="6228 983" /> <Input id="357" stoichiometry="2" points="6239 725" /> </Inputs> <Outputs> <Output id="141" /> </Outputs> <Catalysts> <Catalyst id="140" points="6216 1007, 6265 1029" /> </Catalysts> <Properties> <displayName>eNOS:Caveolin-1 complex binds to CaM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="285" reactomeId="202129" points="6359 929, 6358 929, 6359 928" position="6358 929" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="141" points="6339 958" /> <Input id="143" points="6406 920" /> </Inputs> <Outputs> <Output id="142" points="6417 961" /> <Output id="357" points="6246 725" /> </Outputs> <Catalysts> <Catalyst id="143" points="6406 903, 6364 892" /> </Catalysts> <Properties> <displayName>HSP90 binds eNOS:Caveolin-1:CaM complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="286" reactomeId="202144" points="6501 984, 6526 984, 6550 985" position="6526 984" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="142" /> </Inputs> <Outputs> <Output id="144" points="6560 948" /> <Output id="145" points="6579 985" /> </Outputs> <Catalysts> <Catalyst id="142" points="6488 1012, 6525 1032" /> </Catalysts> <Properties> <displayName>Caveolin-1 dissociates from eNOS:CaM:HSP90 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="287" reactomeId="202137" points="6648 935, 6694 935, 6739 967" position="6694 935" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="146" points="6637 878" /> <Input id="145" points="6630 965" /> </Inputs> <Outputs> <Output id="147" /> </Outputs> <Catalysts> <Catalyst id="145" points="6664 985, 6695 985" /> </Catalysts> <Properties> <displayName>AKT1 binds eNOS complex via HSP90</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="288" points="6566 858, 6296 860, 5974 893" position="6296 860" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="146" /> </Inputs> <Outputs> <Output id="138" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="289" reactomeId="202111" points="6828 985, 6847 985, 6874 984" position="6847 985" lineWidth="1.0"> <Inputs> <Input id="148" points="6790 938" /> <Input id="147" points="6813 985" /> </Inputs> <Outputs> <Output id="1145" points="6870 936" /> <Output id="149" points="6907 986" /> <Output id="1152" points="6897 962" /> </Outputs> <Catalysts> <Catalyst id="147" points="6792 1007, 6847 1034" /> </Catalysts> <Properties> <displayName>AKT1 phosphorylates eNOS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="290" reactomeId="1497784" points="7071 986, 7099 986, 7096 929" position="7099 986" lineWidth="1.0"> <Inputs> <Input id="149" points="7040 987" /> <Input id="151" points="7005 945" /> </Inputs> <Outputs> <Output id="152" /> </Outputs> <Catalysts> <Catalyst id="149" points="7028 1011, 7099 1031" /> </Catalysts> <Properties> <displayName>The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="291" reactomeId="202127" points="6813 727, 6814 773, 6816 799" position="6814 773" lineWidth="1.0"> <Inputs> <Input id="155" stoichiometry="3" points="6901 720" /> <Input id="154" stoichiometry="2" points="6805 690" /> <Input id="153" points="6734 709" /> <Input id="1156" points="6761 687" /> </Inputs> <Outputs> <Output id="157" stoichiometry="2" points="6830 831" /> <Output id="156" stoichiometry="3" points="6920 823" /> <Output id="158" stoichiometry="2" points="6791 822" /> <Output id="1146" stoichiometry="4" points="6871 836" /> </Outputs> <Catalysts> <Catalyst id="152" points="7028 897, 6741 881, 6739 773" /> </Catalysts> <Inhibitors> <Inhibitor id="338" points="6859 772" /> </Inhibitors> <Properties> <displayName>eNOS synthesizes NO</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="292" reactomeId="5218827" points="7042 666, 7042 686, 7064 708" position="7042 686" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="159" points="7053 666" /> <Input id="367" points="7042 643" /> </Inputs> <Outputs> <Output id="160" /> </Outputs> <Properties> <displayName>NADPH oxidase 2 (NOX2) complex binds RAC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="293" reactomeId="5218841" points="7034 768, 7034 790, 7035 811" position="7034 790" lineWidth="1.0"> <Inputs> <Input id="690" stoichiometry="2" points="7154 768" /> <Input id="155" points="6966 733" /> </Inputs> <Outputs> <Output id="156" points="6986 823" /> <Output id="691" stoichiometry="2" points="7151 811" /> <Output id="162" points="7022 839" /> </Outputs> <Catalysts> <Catalyst id="160" points="7027 727, 7015 727, 7016 777" /> </Catalysts> <Properties> <displayName>NADPH oxidase 2 generates superoxide from oxygen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="294" reactomeId="5218815" points="3370 226, 3383 162, 3422 187" position="3383 162" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="27" points="1112 192, 1202 135, 3349 138" /> <Input id="163" points="3333 279" /> </Inputs> <Outputs> <Output id="164" /> </Outputs> <Properties> <displayName>p-6Y-VEGFR2 binds NCK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="295" reactomeId="5218824" points="3542 215, 3556 215, 3581 215" position="3556 215" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="165" points="3519 275" /> <Input id="164" points="3524 215" /> </Inputs> <Outputs> <Output id="166" /> </Outputs> <Properties> <displayName>p-6Y-VEGFR2 binds FYN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="296" reactomeId="5218806" points="3737 251, 3746 213, 3757 251" position="3746 213" lineWidth="1.0"> <Inputs> <Input id="166" points="3709 243" /> <Input id="167" points="3709 273" /> </Inputs> <Outputs> <Output id="168" points="3784 237" /> <Output id="169" points="3793 277" /> </Outputs> <Catalysts> <Catalyst id="166" points="3647 187, 3647 161, 3746 161" /> </Catalysts> <Properties> <displayName>FYN autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="297" reactomeId="5218854" points="3915 262, 3929 214, 3948 262" position="3929 214" lineWidth="1.0"> <Inputs> <Input id="170" points="3891 280" /> <Input id="168" points="3887 244" /> </Inputs> <Outputs> <Output id="171" points="3976 283" /> <Output id="172" points="3981 242" /> </Outputs> <Catalysts> <Catalyst id="173" points="3929 375" /> </Catalysts> <Properties> <displayName>p-Y420-FYN is phosphorylated on S21</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="298" reactomeId="5218847" points="4082 275, 4109 307, 4153 242" position="4109 307" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="172" points="4053 242" /> <Input id="174" points="4052 331" /> </Inputs> <Outputs> <Output id="175" /> </Outputs> <Properties> <displayName>PAK2 binds NCK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="299" reactomeId="5218829" points="4328 239, 4348 240, 4366 239" position="4348 240" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="176" points="4306 222" /> <Input id="178" points="4303 261" /> </Inputs> <Outputs> <Output id="177" points="4392 217" /> <Output id="179" points="4393 265" /> </Outputs> <Catalysts> <Catalyst id="377" points="4346 297" /> </Catalysts> <Properties> <displayName>VEGF induces CDC42 activation by unknown mechanism</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="300" reactomeId="5218832" points="4421 161, 4464 161, 4491 185" position="4464 161" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="177" stoichiometry="2" points="4408 189" /> <Input id="175" points="4241 195" /> </Inputs> <Outputs> <Output id="180" /> </Outputs> <Properties> <displayName>CDC42:GTP binds PAK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="301" reactomeId="5218814" points="4604 219, 4624 219, 4644 219" position="4624 219" lineWidth="1.0"> <Inputs> <Input id="180" points="4593 219" /> <Input id="181" stoichiometry="4" points="4596 278" /> </Inputs> <Outputs> <Output id="182" stoichiometry="4" points="4648 276" /> <Output id="183" points="4657 219" /> </Outputs> <Catalysts> <Catalyst id="180" points="4593 195, 4624 183" /> </Catalysts> <Properties> <displayName>PAK2 autophorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="302" reactomeId="5218812" points="4809 257, 4824 216, 4835 257" position="4824 216" lineWidth="1.0"> <Inputs> <Input id="184" stoichiometry="2" points="4787 290" /> <Input id="183" points="4792 248" /> </Inputs> <Outputs> <Output id="185" points="4861 245" /> <Output id="186" stoichiometry="2" points="4872 295" /> </Outputs> <Catalysts> <Catalyst id="183" points="4723 188, 4723 167, 4823 167" /> </Catalysts> <Properties> <displayName>FYN phosphorylates PAK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="303" reactomeId="5218804" points="4892 449, 4929 449, 4960 449" position="4929 449" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="187" stoichiometry="2" points="4859 424" /> <Input id="188" points="4864 478" /> </Inputs> <Outputs> <Output id="189" points="4995 473" /> <Output id="190" stoichiometry="2" points="4992 418" /> </Outputs> <Catalysts> <Catalyst id="185" points="4928 255" /> </Catalysts> <Properties> <displayName>p38 MAPK activation by VEGFR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="305" reactomeId="5218916" points="5557 463, 5588 463, 5619 463" position="5588 463" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="195" stoichiometry="3" points="5536 504" /> <Input id="196" points="5514 463" /> </Inputs> <Outputs> <Output id="197" points="5652 427" /> <Output id="198" points="5651 463" /> <Output id="199" stoichiometry="3" points="5651 499" /> </Outputs> <Catalysts> <Catalyst id="193" points="5321 422, 5325 408, 5587 408" /> </Catalysts> <Properties> <displayName>p-MAPK2/3 phosphorylates HSP27</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="306" reactomeId="4420153" points="5016 213, 5046 284, 5082 241" position="5046 284" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="27" points="1101 192, 1188 111, 4993 142" /> <Input id="200" points="4983 295" /> </Inputs> <Outputs> <Output id="201" /> </Outputs> <Properties> <displayName>p-6Y-VEGFR2 binds PLCG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="307" reactomeId="4420121" points="5188 212, 5216 212, 5240 212" position="5216 212" lineWidth="1.0"> <Inputs> <Input id="202" stoichiometry="4" points="5173 245" /> <Input id="201" points="5162 212" /> </Inputs> <Outputs> <Output id="203" points="5267 212" /> <Output id="204" stoichiometry="4" points="5256 257" /> </Outputs> <Catalysts> <Catalyst id="205" points="5216 319" /> </Catalysts> <Properties> <displayName>SFKs phosphorylate PLCG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="308" reactomeId="4420202" points="5399 232, 5428 243, 5428 211" position="5428 243" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="203" /> </Inputs> <Outputs> <Output id="27" points="1091 192, 1165 72, 5115 99, 5405 178" /> <Output id="206" points="5456 212" /> </Outputs> <Properties> <displayName>PLCG1 disassociates from VEGFR2 and translocate to PM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="309" reactomeId="167686" points="5667 216, 5689 214, 5714 214" position="5689 214" lineWidth="1.0"> <Inputs> <Input id="207" points="5645 238" /> <Input id="210" points="5637 216" /> </Inputs> <Outputs> <Output id="209" points="5760 237" /> <Output id="1158" points="5760 214" /> <Output id="1160" points="5707 244" /> </Outputs> <Catalysts> <Catalyst id="206" points="5510 195, 5521 175, 5688 173" /> </Catalysts> <Properties> <displayName>Active PLCG1 hydrolyses PIP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="310" reactomeId="169680" points="5868 255, 5942 268, 5950 312, 5993 313" position="5950 312" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="209" stoichiometry="4" points="5828 255" /> <Input id="1157" points="5871 287" /> </Inputs> <Outputs> <Output id="212" /> </Outputs> <Catalysts> <Catalyst id="1157" points="5915 312" /> </Catalysts> <Properties> <displayName>IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="311" reactomeId="169683" points="5923 389, 6014 395, 6117 397" position="6014 395" lineWidth="1.0"> <Inputs> <Input id="213" /> </Inputs> <Outputs> <Output id="214" /> </Outputs> <Catalysts> <Catalyst id="212" points="6041 336" /> </Catalysts> <Inhibitors> <Inhibitor id="334" points="6015 484" /> </Inhibitors> <Activators> <Activator id="209" points="5790 273, 5811 348" /> </Activators> <Properties> <displayName>IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="312" reactomeId="74448" points="6240 398, 6239 398, 6239 693" position="6239 398" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="689" points="6214 350" /> <Input id="214" stoichiometry="4" points="6173 398" /> </Inputs> <Outputs> <Output id="357" /> </Outputs> <Properties> <displayName>Calcium binds calmodulin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="313" reactomeId="5218821" points="6388 297, 6434 297, 6468 297" position="6434 297" lineWidth="1.0"> <Inputs> <Input id="217" points="6368 280" /> <Input id="218" points="6366 316" /> </Inputs> <Outputs> <Output id="219" points="6499 316" /> <Output id="220" points="6491 278" /> </Outputs> <Catalysts> <Catalyst id="221" points="6433 229" /> </Catalysts> <Properties> <displayName>PDK1 phosphorylates PKC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="314" reactomeId="5218805" points="6635 339, 6668 339, 6703 339" position="6668 339" lineWidth="1.0"> <Inputs> <Input id="219" points="6595 339" /> <Input id="222" stoichiometry="2" points="6618 306" /> </Inputs> <Outputs> <Output id="223" stoichiometry="2" points="6730 308" /> <Output id="224" points="6733 339" /> </Outputs> <Catalysts> <Catalyst id="219" points="6522 364, 6522 390, 6667 390" /> </Catalysts> <Properties> <displayName>PKC autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="315" reactomeId="5218813" points="7085 292, 7085 320, 7085 360" position="7085 320" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="224" points="6792 335" /> <Input id="345" points="7085 266" /> <Input id="347" points="7032 262" /> </Inputs> <Outputs> <Output id="225" /> </Outputs> <Properties> <displayName>DAG and Ca+2 bind to PKC and tether it to membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="316" reactomeId="5218823" points="6595 445, 6628 445, 6656 445" position="6628 445" lineWidth="1.0"> <Inputs> <Input id="226" points="6571 426" /> <Input id="227" points="6562 463" /> </Inputs> <Outputs> <Output id="228" points="6689 464" /> <Output id="229" points="6687 423" /> </Outputs> <Catalysts> <Catalyst id="225" points="7031 381, 6687 384" /> </Catalysts> <Properties> <displayName>PKC phosphorylates sphingosine kinase 1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="317" reactomeId="5218845" points="7076 486, 7076 511, 7076 540" position="7076 511" lineWidth="1.0"> <Inputs> <Input id="230" points="6982 464" /> <Input id="231" points="7076 461" /> </Inputs> <Outputs> <Output id="232" points="6859 518" /> <Output id="233" points="6881 547" /> <Output id="234" points="6952 565" /> <Output id="235" points="7076 570" /> </Outputs> <Catalysts> <Catalyst id="228" points="6767 485" /> </Catalysts> <Properties> <displayName>p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="326" points="301 45, 517 94" position="409 69" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="325" /> </Inputs> <Outputs> <Output id="6" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="327" points="251 56, 263 131" position="257 93" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="325" /> </Inputs> <Outputs> <Output id="10" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="328" points="223 56, 95 114" position="159 85" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="325" /> </Inputs> <Outputs> <Output id="4" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableInteraction id="337" interactionType="Activate" points="7030 587, 6831 602" position="6930 594" lineWidth="2.0"> <Inputs> <Input id="235" /> </Inputs> <Outputs> <Output id="335" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="374" reactomeId="187688" points="5205 519, 5230 519, 5257 519" position="5230 519" lineWidth="1.0"> <Inputs> <Input id="192" points="5163 490" /> <Input id="375" stoichiometry="2" points="5169 543" /> </Inputs> <Outputs> <Output id="376" stoichiometry="2" points="5303 548" /> <Output id="193" points="5285 497" /> </Outputs> <Catalysts> <Catalyst id="189" points="5021 473, 5021 427, 5230 427" /> </Catalysts> <Properties> <displayName>p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="687" reactomeId="8951586" points="4359 988, 4402 986, 4435 985" position="4402 986" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="112" points="4307 985" /> <Input id="365" points="3687 999, 3734 1035, 4334 1019" /> </Inputs> <Outputs> <Output id="562" /> </Outputs> <Properties> <displayName>p-VAV family:PIP3 binds RAC1:GDP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="693" reactomeId="9674532" points="446 634, 511 634, 661 634" position="511 634" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="694" /> </Inputs> <Outputs> <Output id="695" /> </Outputs> <Activators> <Activator id="696" points="481 36" /> </Activators> <Properties> <displayName>AAMP gene expression is positively regulated by VEGF</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="697" points="493 36, 545 80" position="519 58" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="696" /> </Inputs> <Outputs> <Output id="6" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="698" points="441 36, 115 125" position="278 80" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="696" /> </Inputs> <Outputs> <Output id="4" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="699" points="436 24, 301 33" position="368 28" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="696" /> </Inputs> <Outputs> <Output id="325" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="957" reactomeId="9691215" points="796 164, 797 165, 835 196" position="797 165" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="959" points="767 150" /> <Input id="7" points="722 200" /> </Inputs> <Outputs> <Output id="26" /> </Outputs> <Inhibitors> <Inhibitor id="1092" points="825 137" /> </Inhibitors> <Properties> <displayName>VEGFA-165 dimer binds VEGFR2 dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1090" reactomeId="9679477" points="757 72, 757 72, 793 87" position="757 72" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1091" points="757 43" /> <Input id="959" points="735 115" /> </Inputs> <Outputs> <Output id="1092" /> </Outputs> <Properties> <displayName>VEGFA-165 dimer binds VEGFA inhibitors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1144" interactionType="Activate" points="6686 501, 6585 554" position="6635 527" lineWidth="2.0"> <Inputs> <Input id="228" /> </Inputs> <Outputs> <Output id="1143" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
width7199
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of Signaling by VEGF (500413)
Follow Reactome