Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Transcriptional regulation of pluripotent stem cells

Class:IdPathwayDiagram:500404
_displayNameDiagram of Transcriptional regulation of pluripotent stem cells
_timestamp2019-02-21 19:54:24
created[InstanceEdit:500403] May, B, 2010-02-03
height1070
modified[InstanceEdit:1011562] May, B, 2010-11-11
[InstanceEdit:1013049] May, B, 2010-11-12
[InstanceEdit:1013055] May, B, 2010-11-12
[InstanceEdit:1112614] May, B, 2010-12-06
[InstanceEdit:1485617] May, B, 2011-08-12
[InstanceEdit:2889039] May, B, 2012-12-31
[InstanceEdit:2892248] May, B, 2013-01-01
[InstanceEdit:2895781] May, B, 2013-01-03
[InstanceEdit:2972982] D'Eustachio, P, 2013-01-06
[InstanceEdit:2975873] May, B, 2013-01-09
[InstanceEdit:3109802] May, B, 2013-02-10
[InstanceEdit:5159237] D'Eustachio, P, 2013-11-22
[InstanceEdit:5163275] May, B, 2013-11-24
[InstanceEdit:5164024] May, B, 2013-11-24
[InstanceEdit:5185723] May, B, 2013-11-29
[InstanceEdit:5187432] May, B, 2013-11-30
[InstanceEdit:5251384] May, B, 2014-02-03
[InstanceEdit:5638458] May, Bruce, 2014-11-15
[InstanceEdit:8939408] May, Bruce, 2016-09-18
[InstanceEdit:9628697] May, Bruce, 2018-11-12
[InstanceEdit:9629283] May, Bruce, 2018-11-20
[InstanceEdit:9637872] Matthews, Lisa, 2019-02-21
representedPathway[Pathway:452723] Transcriptional regulation of pluripotent stem cells [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="339" reactomeDiagramId="500404"> <Properties> <displayName>Diagram of Transcriptional regulation of pluripotent stem cells</displayName> </Properties> <Nodes> <org.gk.render.RenderableCompartment id="2" reactomeId="70101" position="844 533" bounds="4 4 1680 1058" textPosition="22 853" bgColor="250 240 240" lineColor="255 153 102" insets="15 13 1654 1040"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="94" /> <Component id="92" /> <Component id="93" /> <Component id="89" /> <Component id="192" /> <Component id="3" /> <Component id="330" /> <Component id="332" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="3" reactomeId="7660" position="932 524" bounds="215 45 1434 958" textPosition="231 936" bgColor="250 240 240" lineColor="255 153 102" insets="228 56 1407 940"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="10" /> <Component id="11" /> <Component id="12" /> <Component id="13" /> <Component id="14" /> <Component id="16" /> <Component id="17" /> <Component id="19" /> <Component id="20" /> <Component id="24" /> <Component id="37" /> <Component id="78" /> <Component id="79" /> <Component id="98" /> <Component id="35" /> <Component id="36" /> <Component id="21" /> <Component id="177" /> <Component id="179" /> <Component id="180" /> <Component id="188" /> <Component id="189" /> <Component id="190" /> <Component id="193" /> <Component id="194" /> <Component id="247" /> <Component id="250" /> <Component id="251" /> <Component id="249" /> <Component id="191" /> <Component id="178" /> <Component id="195" /> <Component id="97" /> <Component id="255" /> <Component id="256" /> <Component id="248" /> <Component id="267" /> <Component id="269" /> <Component id="271" /> <Component id="273" /> <Component id="275" /> <Component id="277" /> <Component id="318" /> <Component id="328" /> <Component id="329" /> <Component id="331" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="11" reactomeId="452472" position="706 657" bounds="653 644 106 26" textPosition="679 646"> <Properties> <displayName>POU5F1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="12" reactomeId="480572" position="1396 492" bounds="1334 473 124 38" textPosition="1336 476" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POU5F1:SOX2:NANOG:SOX2 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="13" reactomeId="452560" position="778 157" bounds="745 143 66 29" textPosition="756 147"> <Properties> <displayName>EPAS1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="14" reactomeId="452955" position="270 194" bounds="239 183 62 23" textPosition="246 184"> <Properties> <displayName>NR5A1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="17" reactomeId="452271" position="1479 665" bounds="1445 653 69 24" textPosition="1460 654"> <Properties> <displayName>SOX2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="20" reactomeId="452586" position="1060 659" bounds="1029 645 62 28" textPosition="1034 648"> <Properties> <displayName>NANOG</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="21" reactomeId="480463" position="953 463" bounds="874 439 158 49" textPosition="880 439" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="36" reactomeId="453045" position="795 317" bounds="771 307 49 20" textPosition="777 307"> <Properties> <displayName>PBX1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="37" reactomeId="434463" position="795 292" bounds="770 282 51 21" textPosition="777 282"> <Properties> <displayName>KLF4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="79" reactomeId="453015" position="852 112" bounds="811 99 82 27" textPosition="830 102"> <Properties> <displayName>HIF3A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="89" reactomeId="500373" position="106 671" bounds="43 651 127 41" textPosition="58 657" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIN28:POU5F1 mRNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="93" reactomeId="500391" position="60 536" bounds="20 521 81 31" textPosition="35 526"> <Properties> <displayName>LIN28A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableRNA id="94" reactomeId="500358" position="122 484" bounds="68 458 109 52" textPosition="75 473"> <Properties> <displayName>POU5F1 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableProtein id="98" reactomeId="452644" position="288 776" bounds="252 765 73 23" textPosition="267 766"> <Properties> <displayName>SALL4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="177" reactomeId="1112611" position="419 482" bounds="319 456 201 52" textPosition="319 459" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="179" reactomeId="480774" position="509 318" bounds="475 308 69 20" textPosition="478 308"> <Properties> <displayName>ZSCAN10</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="180" reactomeId="1112608" position="490 291" bounds="458 280 64 22" textPosition="462 280"> <Properties> <displayName>PRDM14</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="188" reactomeId="2888972" position="884 280" bounds="831 255 106 51" textPosition="842 282"> <Properties> <displayName>NANOG gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="189" reactomeId="206827" position="688 373" bounds="594 362 188 23" textPosition="602 364" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SMAD4:p-SMAD2:p-SMAD2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="190" reactomeId="2888991" position="1339 307" bounds="1301 282 77 51" textPosition="1304 309"> <Properties> <displayName>SOX2 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableGene id="191" reactomeId="2888984" position="365 311" bounds="311 286 108 51" textPosition="322 313"> <Properties> <displayName>POU5F1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableGene id="193" reactomeId="2888960" position="713 86" bounds="671 61 85 51" textPosition="676 88"> <Properties> <displayName>EPAS1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="194" reactomeId="2889026" position="449 776" bounds="393 758 113 37" textPosition="400 760" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POU5F1:STAT3:SALL4 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="195" reactomeId="2889008" position="366 847" bounds="325 829 83 37" textPosition="323 831" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SALL4:SALL4 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="247" reactomeId="2892247" position="893 924" bounds="690 887 406 75" textPosition="719 903"> <Properties> <displayName>POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="248" reactomeId="2892245" position="1328 924" bounds="1126 887 405 74" textPosition="1155 902"> <Properties> <displayName>POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="250" reactomeId="1112525" position="672 779" bounds="609 761 126 36" textPosition="621 762" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y705-STAT3 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="251" reactomeId="2888956" position="509 838" bounds="469 813 81 51" textPosition="472 840"> <Properties> <displayName>SALL4 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="256" reactomeId="480800" position="1118 527" bounds="1100 516 37 22" textPosition="1101 516"> <Properties> <displayName>ZIC3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="318" reactomeId="8939362" position="678 346" bounds="644 335 68 22" textPosition="645 335"> <Properties> <displayName>FOXP1-ES</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="329" reactomeId="8939370" position="277 99" bounds="243 74 68 51" textPosition="252 101"> <Properties> <displayName>FOXP1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableRNA id="330" reactomeId="8939390" position="102 144" bounds="48 115 108 58" textPosition="47 126"> <Properties> <displayName>FOXP1 mRNA (ES isoform)</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="331" reactomeId="8939395" position="418 145" bounds="343 133 150 25" textPosition="351 137" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MBNL1,2:FOXP1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="10" reactomeId="452392" points="428 288, 423 350, 269 492, 180 486" position="269 492" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="191" /> </Inputs> <Outputs> <Output id="94" /> </Outputs> <Activators> <Activator id="13" points="742 163, 289 257" /> <Activator id="14" points="269 209" /> <Activator id="177" points="316 488" /> </Activators> <Properties> <displayName>Transcription of POU5F1 (OCT4)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16" reactomeId="452894" points="1387 284, 1491 495, 1479 650" position="1491 495" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="190" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> <Activators> <Activator id="13" points="814 162, 1491 270" /> <Activator id="12" points="1461 493" /> </Activators> <Properties> <displayName>Expression of SOX2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="19" reactomeId="452838" points="946 257, 1027 295, 1054 519, 1059 642" position="1054 519" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="188" /> </Inputs> <Outputs> <Output id="20" /> </Outputs> <Activators> <Activator id="13" points="814 169, 1052 260" /> <Activator id="256" points="1097 524" /> <Activator id="21" points="997 491" /> </Activators> <Properties> <displayName>Expression of NANOG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="480685" points="1395 355, 1396 396, 1396 470" position="1396 396" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="20" points="1087 642, 1302 535, 1302 363" /> <Input id="17" points="1464 650, 1315 532, 1314 373" /> <Input id="11" points="762 645, 1292 531, 1293 352" /> <Input id="190" points="1387 284" /> </Inputs> <Outputs> <Output id="12" /> </Outputs> <Properties> <displayName>POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="35" reactomeId="480204" points="948 329, 950 402, 951 436" position="950 402" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="17" points="1442 655, 838 493, 841 367" /> <Input id="36" points="823 318" /> <Input id="318" points="715 343" /> <Input id="188" points="946 257" /> <Input id="189" points="755 359" /> <Input id="20" points="1040 642, 830 494, 834 361" /> <Input id="11" points="715 641, 823 495, 828 355" /> <Input id="37" points="824 298" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> <Properties> <displayName>POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="78" reactomeId="480301" points="765 63, 778 119, 778 140" position="778 119" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="193" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> <Activators> <Activator id="79" points="808 115" /> </Activators> <Properties> <displayName>Expression of EPAS1 (HIF2A)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="92" reactomeId="500366" points="116 555, 113 595, 107 648" position="113 595" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="93" points="104 549" /> <Input id="94" points="119 505" /> </Inputs> <Outputs> <Output id="89" /> </Outputs> <Properties> <displayName>LIN28 binds POU5F1 (OCT4) mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="97" reactomeId="480520" points="559 815, 386 809, 365 775, 328 775" position="365 775" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="251" /> </Inputs> <Outputs> <Output id="98" /> </Outputs> <Inhibitors> <Inhibitor id="195" points="365 826" /> </Inhibitors> <Activators> <Activator id="194" points="390 775" /> </Activators> <Properties> <displayName>Expression of SALL4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="178" reactomeId="1112609" points="433 339, 428 393, 421 453" position="428 393" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="17" points="1442 659, 560 523, 551 358" /> <Input id="180" points="476 305" /> <Input id="318" points="641 345" /> <Input id="189" points="601 359" /> <Input id="20" points="1026 650, 554 527, 545 364" /> <Input id="11" points="689 641, 544 527, 539 371" /> <Input id="191" points="428 288" /> <Input id="179" points="472 327" /> <Input id="98" points="299 762, 535 530, 530 378" /> </Inputs> <Outputs> <Output id="177" /> </Outputs> <Properties> <displayName>POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="192" reactomeId="2889036" points="133 505, 204 669, 650 658" position="204 669" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="94" /> </Inputs> <Outputs> <Output id="11" /> </Outputs> <Activators> <Activator id="89" points="173 669" /> </Activators> <Properties> <displayName>Translation of OCT4 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="249" reactomeId="2895778" points="552 777, 530 778, 509 777" position="530 778" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="250" points="606 777" /> <Input id="251" points="559 815" /> <Input id="11" points="689 673" /> </Inputs> <Outputs> <Output id="194" /> </Outputs> <Properties> <displayName>POU5F1 (OCT4), STAT3 bind the SALL4 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="255" reactomeId="2972968" points="369 932, 368 905, 366 869" position="368 905" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="251" points="559 815, 597 865, 554 932" /> <Input id="98" points="288 791, 289 932" /> </Inputs> <Outputs> <Output id="195" /> </Outputs> <Properties> <displayName>SALL4 binds the SALL4 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="267" interactionType="Activate" points="724 673, 864 768, 886 884" position="864 768" lineWidth="2.0"> <Inputs> <Input id="11" /> </Inputs> <Outputs> <Output id="247" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="269" interactionType="Activate" points="1038 676, 886 770, 891 884" position="886 770" lineWidth="2.0"> <Inputs> <Input id="20" /> </Inputs> <Outputs> <Output id="247" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="271" interactionType="Activate" points="1442 671, 905 772, 895 884" position="905 772" lineWidth="2.0"> <Inputs> <Input id="17" /> </Inputs> <Outputs> <Output id="247" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="273" interactionType="Inhibit" points="1465 680, 1336 791, 1330 884" position="1336 791" lineWidth="2.0"> <Inputs> <Input id="17" /> </Inputs> <Outputs> <Output id="248" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="275" interactionType="Inhibit" points="1088 676, 1316 783, 1324 884" position="1316 783" lineWidth="2.0"> <Inputs> <Input id="20" /> </Inputs> <Outputs> <Output id="248" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="277" interactionType="Inhibit" points="762 668, 1295 788, 1319 884" position="1295 788" lineWidth="2.0"> <Inputs> <Input id="11" /> </Inputs> <Outputs> <Output id="248" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="328" reactomeId="8939357" points="320 76, 323 150, 159 145" position="323 150" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="329" /> </Inputs> <Outputs> <Output id="330" /> </Outputs> <Inhibitors> <Inhibitor id="331" points="340 148" /> </Inhibitors> <Properties> <displayName>Transcription of FOXP1 to yield embryonic-specific mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="332" reactomeId="8939375" points="159 151, 201 157, 655 228, 675 332" position="201 157" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="330" /> </Inputs> <Outputs> <Output id="318" /> </Outputs> <Properties> <displayName>Translation of FOXP1 mRNA (ES-specific isoform)</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
width1692
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of Transcriptional regulation of pluripotent stem cells (500404)