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Details on Person UniProt:P01008 SERPINC1
| Class:Id | ReferenceGeneProduct:50040 |
|---|---|
| _chainChangeLog | signal peptide:1-32 added on Fri February 6 2015;chain:33-464 added on Fri February 6 2015 |
| _displayName | UniProt:P01008 SERPINC1 |
| _timestamp | 2024-11-03 19:59:45 |
| chain | signal peptide:1-32 chain:33-464 |
| checksum | 9A4E324F00683D9D |
| comment | FUNCTION Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15140129, PubMed:15853774). AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129). Its inhibitory activity is greatly enhanced in the presence of heparin.SUBUNIT Forms protease inhibiting heterodimer with TMPRSS7.INTERACTION Found in plasma.PTM Phosphorylated by FAM20C in the extracellular medium.MASS SPECTROMETRY Variant Thr-414.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the serpin family.ONLINE INFORMATION Antithrombin entry |
| description | recommendedName: Antithrombin-III shortName: ATIII alternativeName: Serpin C1 |
| geneName | SERPINC1 AT3 PRO0309 |
| identifier | P01008 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Heparin-binding Phosphoprotein Protease inhibitor Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal Thrombophilia |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SERPINC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989375] ENSEMBL:ENSG00000117601 SERPINC1 [Homo sapiens] |
| secondaryIdentifier | ANT3_HUMAN B2R6P0 P78439 P78447 Q13815 Q5TC78 Q7KZ43 Q7KZ97 Q9UC78 |
| sequenceLength | 464 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:140792] SERPINC1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:140807] SERPINC1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140814] SERPINC1(33-425) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140815] SERPINC1(33-425) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:140816] SERPINC1(426-464) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:140817] SERPINC1(426-464) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8956773] SERPINC1 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:8957069] p-SERPINC1 [endoplasmic reticulum lumen] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8956888] phosphorylated residue at unknown position |
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No pathways have been reviewed or authored by UniProt:P01008 SERPINC1 (50040)
