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Details on Person The NANOG gene is transcribed to yield mRNA and the mRNA is ...
| Class:Id | Summation:500376 |
|---|---|
| _displayName | The NANOG gene is transcribed to yield mRNA and the mRNA is ... |
| _timestamp | 2014-01-23 02:07:44 |
| created | [InstanceEdit:500370] May, B, 2010-02-03 |
| modified | [InstanceEdit:500403] May, B, 2010-02-03 [InstanceEdit:1014235] May, B, 2010-11-13 [InstanceEdit:1101836] May, B, 2010-12-01 [InstanceEdit:2888916] May, B, 2012-12-31 [InstanceEdit:2892231] May, B, 2012-12-31 [InstanceEdit:3656308] May, B, 2013-06-03 [InstanceEdit:5159238] D'Eustachio, P, 2013-11-22 [InstanceEdit:5244494] May, B, 2014-01-18 [InstanceEdit:5246733] May, B, 2014-01-23 |
| text | The NANOG gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Chambers et al. 2003, Hart et al. 2004, Hatano et al. 2005, Hyslop et al. 2005, Li et al. 2006). NANOG protein is not detected in oocytes or early cleavage-stage embryos, but is seen later in some but not all nuclei of the inner cell mass of blastocysts (Cauffman et al. 2009). KLF4, PBX1, POU5F1 (OCT4), SOX2, NANOG, and SMAD2 bind the promoter of the NANOG gene and enhance transcription (Boyer et al. 2005, Rodda et al. 2005, Kuroda et al. 2005, Babaie et al. 2007, Assou et al. 2007, Greber et al. 2007, Vallier et al. 2009, Brown et al. 2011). Activation-induced cytidine deaminase (AID) binds the methylated NANOG promoter and demethylates it (Bhutani et al. 2009). Hypoxia acts via HIF3A and EPAS1 (HIF2A) to enhance expression of NANOG (Forristal et al. 2010). In mouse Nanog negatively regulates its own expression and this may account for the heterogeneous expression observed in cells of the inner cell mass (Fidalgo et al. 2012, Navarro et al. 2012). In human embryonic stem cells NANOG has been observed to be expressed monoallelically in the early pre-implantation embryo then expression becomes biallelic (Miyanari and Torres-Padilla 2012), however this is controversial because expreiments in mouse embryonic stem cells have shown biallelic expression (Faddah et al. 2013, Filipczyk et al. 2013). POU5F1 and SOX2 bind adjacent sites at the promoter and form a heterodimer on the DNA. In mice KLF4 interacts with POU5F1 and SOX2. |
| (summation) | [BlackBoxEvent:452838] Expression of NANOG [Homo sapiens] |
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