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Details on Person Diagram of Phase I - Functionalization of compounds, Defective CYP11A1 causes AICSR, Defective CYP11B1 causes AH4, Defective CYP11B2 causes CMO-1 deficiency, Defective CYP19A1 causes AEXS, Defective CYP1B1 causes Glaucoma, Defective CYP21A2 causes AH3, Defective CYP24A1 causes HCAI, Defective CYP26B1 causes RHFCA, Defective CYP26C1 causes FFDD4, Defective CYP2U1 causes SPG56, Defective CYP4F22 causes ARCI5, Defective CYP7B1 causes SPG5A and CBAS3, Defective FMO3 causes TMAU, Defective MAOA causes BRUNS, and Defective TBXAS1 causes GHDD
| Class:Id | PathwayDiagram:500339 |
|---|---|
| _displayName | Diagram of Phase I - Functionalization of compounds, Defective CYP11A1 causes AICSR, Defective CYP11B1 causes AH4, Defective CYP11B2 causes CMO-1 deficiency, Defective CYP19A1 causes AEXS, Defective CYP1B1 causes Glaucoma, Defective CYP21A2 causes AH3, Defective CYP24A1 causes HCAI, Defective CYP26B1 causes RHFCA, Defective CYP26C1 causes FFDD4, Defective CYP2U1 causes SPG56, Defective CYP4F22 causes ARCI5, Defective CYP7B1 causes SPG5A and CBAS3, Defective FMO3 causes TMAU, Defective MAOA causes BRUNS, and Defective TBXAS1 causes GHDD |
| _timestamp | 2026-05-04 14:44:53 |
| created | [InstanceEdit:500340] Jassal, B, 2010-02-03 |
| height | 2016 |
| modified | [InstanceEdit:1679954] Wu, G, 2011-10-20 [InstanceEdit:2455547] Jassal, B, 2012-08-24 [InstanceEdit:2603292] D'Eustachio, P, 2012-11-19 [InstanceEdit:3008836] Gillespie, ME, 2013-02-01 [InstanceEdit:3027890] Gillespie, ME, 2013-02-05 [InstanceEdit:3063319] Gillespie, ME, 2013-02-06 [InstanceEdit:3215463] Gillespie, ME, 2013-03-15 [InstanceEdit:3219410] Gillespie, ME, 2013-03-15 [InstanceEdit:3219413] Gillespie, ME, 2013-03-15 [InstanceEdit:3219416] Gillespie, ME, 2013-03-15 [InstanceEdit:3219419] Gillespie, ME, 2013-03-15 [InstanceEdit:3219422] Gillespie, ME, 2013-03-15 [InstanceEdit:3219425] Gillespie, ME, 2013-03-15 [InstanceEdit:3219428] Gillespie, ME, 2013-03-15 [InstanceEdit:3219431] Gillespie, ME, 2013-03-15 [InstanceEdit:3219434] Gillespie, ME, 2013-03-15 [InstanceEdit:3219437] Gillespie, ME, 2013-03-15 [InstanceEdit:3219440] Gillespie, ME, 2013-03-15 [InstanceEdit:3222322] Gillespie, ME, 2013-03-19 [InstanceEdit:3222329] Gillespie, ME, 2013-03-19 [InstanceEdit:3222365] Gillespie, ME, 2013-03-19 [InstanceEdit:3222381] Gillespie, ME, 2013-03-19 [InstanceEdit:3222382] Gillespie, ME, 2013-03-19 [InstanceEdit:3222383] Gillespie, ME, 2013-03-19 [InstanceEdit:3222395] Gillespie, ME, 2013-03-19 [InstanceEdit:3222398] Gillespie, ME, 2013-03-19 [InstanceEdit:3222412] Gillespie, ME, 2013-03-19 [InstanceEdit:3222451] Gillespie, ME, 2013-03-19 [InstanceEdit:3222454] Gillespie, ME, 2013-03-19 [InstanceEdit:3229082] Gillespie, ME, 2013-03-26 [InstanceEdit:3229085] Gillespie, ME, 2013-03-26 [InstanceEdit:3229156] Gillespie, ME, 2013-03-26 [InstanceEdit:3229178] Gillespie, ME, 2013-03-26 [InstanceEdit:3229235] Gillespie, ME, 2013-03-26 [InstanceEdit:5545499] Jassal, Bijay, 2014-05-22 [InstanceEdit:5580284] Jassal, Bijay, 2014-06-10 [InstanceEdit:5600618] Jassal, Bijay, 2014-06-12 [InstanceEdit:5601814] Jassal, Bijay, 2014-06-13 [InstanceEdit:5607772] Jassal, Bijay, 2014-07-14 [InstanceEdit:5622094] Matthews, Lisa, 2014-09-10 [InstanceEdit:5623545] Jassal, Bijay, 2014-09-15 [InstanceEdit:5623546] Jassal, Bijay, 2014-09-15 [InstanceEdit:5634115] Jassal, Bijay, 2014-11-03 [InstanceEdit:5638344] Jassal, Bijay, 2014-11-14 [InstanceEdit:6783228] Jassal, Bijay, 2015-06-11 [InstanceEdit:6783232] Jassal, Bijay, 2015-06-11 [InstanceEdit:6783318] Jassal, Bijay, 2015-06-11 [InstanceEdit:6783357] Jassal, Bijay, 2015-06-12 [InstanceEdit:6783369] Jassal, Bijay, 2015-06-12 [InstanceEdit:6784307] Jassal, Bijay, 2015-06-19 [InstanceEdit:6784613] Jassal, Bijay, 2015-06-22 [InstanceEdit:6788560] Jassal, Bijay, 2015-07-23 [InstanceEdit:6793920] Jassal, Bijay, 2015-09-04 [InstanceEdit:6793941] Jassal, Bijay, 2015-09-04 [InstanceEdit:8847928] Jassal, Bijay, 2015-12-03 [InstanceEdit:8941454] Jassal, Bijay, 2016-10-03 [InstanceEdit:8941466] Jassal, Bijay, 2016-10-03 [InstanceEdit:8941467] Jassal, Bijay, 2016-10-03 [InstanceEdit:8941469] Jassal, Bijay, 2016-10-03 [InstanceEdit:8942255] Jassal, Bijay, 2016-10-11 [InstanceEdit:8943590] Jassal, Bijay, 2016-10-27 [InstanceEdit:8943592] Jassal, Bijay, 2016-10-27 [InstanceEdit:8943593] Jassal, Bijay, 2016-10-27 [InstanceEdit:8943594] Jassal, Bijay, 2016-10-27 [InstanceEdit:8948694] Matthews, Lisa, 2016-11-15 [InstanceEdit:8959597] Jassal, Bijay, 2017-01-27 [InstanceEdit:9032685] Jassal, Bijay, 2017-12-18 [InstanceEdit:9033261] Jassal, Bijay, 2017-12-20 [InstanceEdit:9035959] Jassal, Bijay, 2018-01-25 [InstanceEdit:9617029] Jassal, Bijay, 2018-08-16 [InstanceEdit:9625157] Jassal, Bijay, 2018-10-19 [InstanceEdit:9628700] Jassal, Bijay, 2018-11-12 [InstanceEdit:9690612] Jassal, Bijay, 2020-06-03 [InstanceEdit:9690958] Jassal, Bijay, 2020-06-08 [InstanceEdit:9696610] Jassal, Bijay, 2020-07-23 [InstanceEdit:9697345] Jassal, Bijay, 2020-08-13 [InstanceEdit:9697448] Jassal, Bijay, 2020-08-17 [InstanceEdit:9697449] Jassal, Bijay, 2020-08-17 [InstanceEdit:9713162] Jassal, Bijay, 2021-01-21 [InstanceEdit:9772976] Matthews, Lisa, 2022-04-25 [InstanceEdit:9773225] Matthews, Lisa, 2022-05-03 [InstanceEdit:9773228] Matthews, Lisa, 2022-05-03 [InstanceEdit:9774094] Matthews, Lisa, 2022-05-13 [InstanceEdit:9796679] D'Eustachio, Peter, 2022-08-11 [InstanceEdit:9815306] D'Eustachio, Peter, 2022-08-16 [InstanceEdit:9838651] D'Eustachio, Peter, 2023-06-23 [InstanceEdit:9838900] D'Eustachio, Peter, 2023-06-27 [InstanceEdit:9838903] D'Eustachio, Peter, 2023-06-27 [InstanceEdit:9907727] D'Eustachio, Peter, 2024-04-15 [InstanceEdit:9907736] D'Eustachio, Peter, 2024-04-15 [InstanceEdit:9907746] D'Eustachio, Peter, 2024-04-16 [InstanceEdit:9907889] D'Eustachio, Peter, 2024-04-17 [InstanceEdit:9915777] D'Eustachio, Peter, 2024-07-15 [InstanceEdit:9918575] Matthews, Lisa, 2024-08-17 [InstanceEdit:9947129] D'Eustachio, Peter, 2025-05-01 [InstanceEdit:9961096] D'Eustachio, Peter, 2025-07-18 [InstanceEdit:9983646] Stephan, Ralf, 2026-02-25 [InstanceEdit:9988143] D'Eustachio, Peter, 2026-05-04 |
| representedPathway | [Pathway:211945] Phase I - Functionalization of compounds [Homo sapiens] [Pathway:5579026] Defective CYP11A1 causes AICSR [Homo sapiens] [Pathway:5579017] Defective CYP11B1 causes AH4 [Homo sapiens] [Pathway:5579009] Defective CYP11B2 causes CMO-1 deficiency [Homo sapiens] [Pathway:5579030] Defective CYP19A1 causes AEXS [Homo sapiens] [Pathway:5579000] Defective CYP1B1 causes Glaucoma [Homo sapiens] [Pathway:5579021] Defective CYP21A2 causes AH3 [Homo sapiens] [Pathway:5579010] Defective CYP24A1 causes HCAI [Homo sapiens] [Pathway:5579015] Defective CYP26B1 causes RHFCA [Homo sapiens] [Pathway:5579004] Defective CYP26C1 causes FFDD4 [Homo sapiens] [Pathway:5579011] Defective CYP2U1 causes SPG56 [Homo sapiens] [Pathway:5579005] Defective CYP4F22 causes ARCI5 [Homo sapiens] [Pathway:5579013] Defective CYP7B1 causes SPG5A and CBAS3 [Homo sapiens] [Pathway:5579019] Defective FMO3 causes TMAU [Homo sapiens] [Pathway:5579012] Defective MAOA causes BRUNS [Homo sapiens] [Pathway:5579032] Defective TBXAS1 causes GHDD [Homo sapiens] |
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bounds="9183 696 34 31" textPosition="9187 700" /> <org.gk.render.RenderableChemical id="487" reactomeId="113535" position="8801 596" bounds="8784 581 34 31" textPosition="8788 585" /> <org.gk.render.RenderableChemical id="556" reactomeId="29510" position="7982 1605" bounds="7948 1590 68 31" textPosition="7952 1594" /> <org.gk.render.RenderableChemical id="557" reactomeId="76577" position="7924 1766" bounds="7903 1751 42 31" textPosition="7907 1755" /> <org.gk.render.RenderableChemical id="558" reactomeId="113526" position="8665 1550" bounds="8639 1535 53 31" textPosition="8643 1539" /> <org.gk.render.RenderableChemical id="559" reactomeId="113592" position="8197 1830" bounds="8177 1815 40 31" textPosition="8181 1819"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="560" reactomeId="29362" position="8885 1569" bounds="8859 1554 52 31" textPosition="8863 1558" /> <org.gk.render.RenderableChemical 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hideComponents="true"> <Properties> <displayName>ALDH2 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="567" reactomeId="73473" position="8158 1679" bounds="8132 1664 52 31" textPosition="8136 1668" /> <org.gk.render.RenderableChemical id="568" reactomeId="113559" position="9132 1608" bounds="9102 1593 61 31" textPosition="9106 1597"> <Properties> <displayName>Ac-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="569" reactomeId="113539" position="8937 1606" bounds="8900 1591 75 31" textPosition="8904 1595" /> <org.gk.render.RenderableProtein id="570" reactomeId="71733" position="8038 1871" bounds="8016 1860 45 23" textPosition="8016 1860"> <Properties> <displayName>ACSS2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="571" reactomeId="71689" position="8042 1701" bounds="7983 1690 119 23" textPosition="7983 1691" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ALDH1A1 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="572" reactomeId="113593" position="8972 1576" bounds="8952 1561 40 31" textPosition="8956 1565" /> <org.gk.render.RenderableChemical id="573" reactomeId="29416" position="8161 1781" bounds="8124 1766 75 31" textPosition="8128 1770"> <Properties> <displayName>CH3COO-</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="574" reactomeId="30203" position="7846 1530" bounds="7823 1515 46 31" textPosition="7827 1519"> <Properties> <displayName>EtOH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="575" reactomeId="29374" position="8974 1638" bounds="8943 1623 62 31" textPosition="8947 1627" /> <org.gk.render.RenderableChemical id="576" reactomeId="159450" position="9106 1572" bounds="9089 1557 34 31" textPosition="9093 1561" /> <org.gk.render.RenderableChemical id="577" reactomeId="29356" position="7890 1643" bounds="7869 1628 43 31" textPosition="7873 1632" /> <org.gk.render.RenderableChemical id="578" reactomeId="113532" position="8623 1604" bounds="8589 1589 68 31" textPosition="8593 1593"> <Properties> <displayName>CH3CHO</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="579" reactomeId="449883" position="7923 1479" bounds="7872 1454 102 51" textPosition="7872 1454"> <Properties> <displayName>alcohol dehydrogenase complex</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="580" reactomeId="449914" position="9039 1543" bounds="9017 1532 45 23" textPosition="9017 1532"> <Properties> <displayName>ACSS1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="581" reactomeId="111294" position="7917 1848" bounds="7900 1833 34 31" textPosition="7904 1837"> <Properties> <displayName>PPi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="582" reactomeId="113529" position="8856 1666" bounds="8838 1651 36 31" textPosition="8842 1655" /> <org.gk.render.RenderableChemical id="583" reactomeId="159448" position="9114 1652" bounds="9093 1637 42 31" textPosition="9097 1641"> <Properties> <displayName>AMP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="591" reactomeId="29360" position="7850 1586" bounds="7824 1571 53 31" textPosition="7828 1575" /> <org.gk.render.RenderableChemical id="593" reactomeId="73473" position="8049 1512" bounds="8023 1497 52 31" textPosition="8027 1501" /> <org.gk.render.RenderableChemical id="595" reactomeId="70106" position="8167 1642" bounds="8149 1627 36 31" textPosition="8153 1631" /> <org.gk.render.RenderableChemical id="624" reactomeId="266056" position="818 334" bounds="795 319 46 31" textPosition="799 323"> <Properties> <displayName>LTB4</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="625" reactomeId="29356" position="630 371" bounds="609 356 43 31" textPosition="613 360" /> <org.gk.render.RenderableChemical id="626" reactomeId="2161636" position="567 334" bounds="524 319 87 31" textPosition="528 323"> <Properties> <displayName>20OH-LTB4</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="630" reactomeId="1502544" position="9092 1234" bounds="9039 1223 106 23" textPosition="9039 1223"> <Properties> <displayName>POMC(138-176)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="632" reactomeId="428986" position="2218 1362" bounds="2176 1351 85 23" textPosition="2176 1352" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PTGS1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> 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bounds="6194 411 116 37" textPosition="6194 411"> <Properties> <displayName>Cytochrome P450 (CYP2E1 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="676" reactomeId="2980785" position="7783 633" bounds="7757 622 53 23" textPosition="7757 622"> <Properties> <displayName>CYP2S1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="678" reactomeId="2980797" position="5853 1035" bounds="5822 1024 63 23" textPosition="5822 1024"> <Properties> <displayName>CYP3A43</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="315" reactomeId="113748" position="5903 688" bounds="5880 673 46 31" textPosition="5884 677" /> <org.gk.render.RenderableChemical id="301" reactomeId="113745" position="6168 701" bounds="6134 686 68 31" textPosition="6138 690" /> <org.gk.render.RenderableChemical id="622" reactomeId="113534" position="5945 652" bounds="5928 637 34 31" textPosition="5932 641" /> <org.gk.render.RenderableChemical id="324" reactomeId="113601" position="5918 741" bounds="5889 726 59 31" textPosition="5893 730" /> <org.gk.render.RenderableChemical id="335" reactomeId="156540" position="5998 748" bounds="5980 733 36 31" textPosition="5984 737" /> <org.gk.render.RenderableChemical id="680" reactomeId="113519" position="6127 752" bounds="6106 737 43 31" textPosition="6110 741" /> <org.gk.render.RenderableChemical id="685" reactomeId="113564" position="6147 641" bounds="6117 626 60 31" textPosition="6121 630" /> <org.gk.render.RenderableEntitySet id="686" reactomeId="3215460" position="4309 942" bounds="4251 924 116 37" textPosition="4251 924"> <Properties> <displayName>Cytochrome P450 (CYP2C8 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="697" reactomeId="2142802" position="3197 1180" bounds="3170 1169 55 23" textPosition="3170 1169"> <Properties> <displayName>CYP2U1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="706" reactomeId="3219409" position="3086 717" bounds="3028 699 116 37" textPosition="3028 699"> <Properties> <displayName>Cytochrome P450 (CYP2D6 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="724" reactomeId="3219412" position="2049 1047" bounds="1991 1029 116 37" textPosition="1991 1029"> <Properties> <displayName>Cytochrome P450 (CYP2A3 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="740" reactomeId="3219414" position="3200 938" bounds="3142 920 116 37" textPosition="3142 920"> <Properties> <displayName>Cytochrome P450 (CYP2C9 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="759" reactomeId="3219417" position="1517 769" bounds="1459 751 116 37" textPosition="1459 751"> <Properties> <displayName>Cytochrome P450 (CYP4B1 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="771" reactomeId="3219421" position="9091 1105" bounds="9033 1087 116 37" textPosition="9033 1087"> <Properties> <displayName>Cytochrome P450 (CYP11B1 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="793" reactomeId="3219427" position="2028 613" bounds="1970 595 116 37" textPosition="1970 595"> <Properties> <displayName>Cytochrome P450 (CYP2B6 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="812" reactomeId="3219430" position="4570 673" bounds="4512 655 116 37" textPosition="4512 655"> <Properties> <displayName>Cytochrome P450 (CYP3A5 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="838" reactomeId="3219438" position="4091 682" bounds="4033 664 116 37" textPosition="4033 664"> <Properties> <displayName>Cytochrome P450 (CYP3A7 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="839" reactomeId="3222321" position="2549 690" bounds="2491 672 116 37" textPosition="2491 672"> <Properties> <displayName>Cytochrome P450 (CYP2F1 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="857" reactomeId="3222327" position="4750 957" bounds="4692 939 116 37" textPosition="4692 939"> <Properties> <displayName>Cytochrome P450 (CYP2C18 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="874" reactomeId="3222363" position="3692 916" bounds="3634 898 116 37" textPosition="3634 898"> <Properties> <displayName>Cytochrome P450 (CYP2C19 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="893" reactomeId="3222379" position="1340 605" bounds="1282 587 116 37" textPosition="1282 587"> <Properties> <displayName>Cytochrome P450 (CYP2J2 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="912" reactomeId="2161611" position="698 429" bounds="634 411 129 37" textPosition="634 411"> <Properties> <displayName>Cytochrome P450 (CYP4F2/4F3 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="926" reactomeId="3222393" position="513 433" bounds="455 415 116 37" textPosition="455 415"> <Properties> <displayName>Cytochrome P450 (CYP4F8 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="937" reactomeId="3222396" position="579 852" bounds="521 834 116 37" textPosition="521 834"> <Properties> <displayName>Cytochrome P450 (CYP4A11 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="954" reactomeId="3222410" position="222 534" bounds="177 523 91 23" textPosition="177 523"> <Properties> <displayName>PTGIS,CYP8B1</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="968" reactomeId="3222449" position="2045 837" bounds="1987 819 116 37" textPosition="1987 819"> <Properties> <displayName>Cytochrome P450 (CYP2A13 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="988" reactomeId="3229080" position="3706 1358" bounds="3648 1340 116 37" textPosition="3648 1340"> <Properties> <displayName>Cytochrome P450 (CYP2W1 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1003" reactomeId="3229083" position="7752 1008" bounds="7694 990 116 37" textPosition="7694 990"> <Properties> <displayName>Cytochrome P450 (CYP4F11 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1014" reactomeId="3229155" position="1156 1008" bounds="1098 990 116 37" textPosition="1098 990"> <Properties> <displayName>Cytochrome P450 (CYP4F12 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1035" reactomeId="3229233" position="3624 681" bounds="3566 663 116 37" textPosition="3566 663"> <Properties> <displayName>Cytochrome P450 (CYPIIIA4 based)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1036" reactomeId="5340274" position="1966 206" bounds="1906 181 121 51" textPosition="1906 182" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1041" reactomeId="5362528" position="7283 429" bounds="7232 418 102 23" textPosition="7232 418"> <Properties> 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position="2869 1225" bounds="2839 1210 60 31" textPosition="2843 1214" /> <org.gk.render.RenderableChemical id="1128" reactomeId="70106" position="2665 1268" bounds="2647 1253 36 31" textPosition="2651 1257" /> <org.gk.render.RenderableChemical id="1130" reactomeId="29364" position="2596 1261" bounds="2567 1246 59 31" textPosition="2571 1250" /> <org.gk.render.RenderableChemical id="1132" reactomeId="29368" position="2619 1229" bounds="2602 1214 34 31" textPosition="2606 1218" /> <org.gk.render.RenderableCompartment id="1133" reactomeId="7660" position="1924 201" bounds="1794 159 261 85" textPosition="1810 169" bgColor="250 240 240" lineColor="255 153 102" insets="1807 166 237 73"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="1036" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="1134" reactomeId="5580249" position="8599 1093" bounds="8541 1075 117 37" textPosition="8541 1076" bgColor="204 255 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textPosition="1055 451" /> <org.gk.render.RenderableChemical id="1248" reactomeId="156540" position="908 540" bounds="890 525 36 31" textPosition="894 529" /> <org.gk.render.RenderableChemical id="1250" reactomeId="113601" position="851 542" bounds="822 527 59 31" textPosition="826 531" /> <org.gk.render.RenderableChemical id="1252" reactomeId="113534" position="874 467" bounds="857 452 34 31" textPosition="861 456" /> <org.gk.render.RenderableChemical id="1265" reactomeId="2142713" position="171 385" bounds="144 370 54 31" textPosition="148 374"> <Properties> <displayName>TrXA3</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1266" reactomeId="29356" position="404 300" bounds="383 285 43 31" textPosition="387 289" /> <org.gk.render.RenderableChemical id="1267" reactomeId="5602281" position="416 379" bounds="369 364 95 31" textPosition="373 368"> <Properties> <displayName>20OH-TrXA3</displayName> </Properties> 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textPosition="4311 1140"> <Properties> <displayName>BEG</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="1317" reactomeId="5693688" position="4184 1146" bounds="4127 1135 114 23" textPosition="4127 1135"> <Properties> <displayName>CES1 trimer, CES2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="1319" reactomeId="156540" position="4282 1239" bounds="4264 1224 36 31" textPosition="4268 1228" /> <org.gk.render.RenderableChemical id="1321" reactomeId="5694080" position="4439 1297" bounds="4406 1282 67 31" textPosition="4410 1286"> <Properties> <displayName>BaP4,5O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1322" reactomeId="29356" position="4449 1256" bounds="4428 1241 43 31" textPosition="4432 1245" /> <org.gk.render.RenderableChemical id="1323" reactomeId="5694091" position="4620 1300" bounds="4574 1285 92 31" textPosition="4578 1289"> <Properties> <displayName>BaP4,5-DHD</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1324" reactomeId="5694132" position="4550 1364" bounds="4526 1353 48 23" textPosition="4526 1353"> <Properties> <displayName>EPHX1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1721" reactomeId="352327" position="738 122" bounds="721 107 34 31" textPosition="725 111" /> <org.gk.render.RenderableChemical id="1722" reactomeId="109276" position="58 109" bounds="37 94 43 31" textPosition="41 98" /> <org.gk.render.RenderableChemical id="1723" reactomeId="390899" position="40 76" bounds="21 61 39 31" textPosition="25 65"> <Properties> <displayName>Hist</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1724" reactomeId="2022135" position="915 122" bounds="894 107 43 31" textPosition="898 111" /> 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</org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1737" reactomeId="5696154" position="943 83" bounds="921 68 45 31" textPosition="925 72"> <Properties> <displayName>BZAL</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1738" reactomeId="5696173" position="821 149" bounds="767 131 109 37" textPosition="767 132" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>AOC3 dimer:2xCu2+:4xCa2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1788" reactomeId="351626" position="190 25" bounds="172 10 36 31" textPosition="176 14" /> <org.gk.render.RenderableChemical id="1790" reactomeId="351629" position="242 31" bounds="217 16 51 31" textPosition="221 20" /> <org.gk.render.RenderableChemical id="1792" reactomeId="351629" position="568 114" bounds="543 99 51 31" textPosition="547 103" /> <org.gk.render.RenderableChemical id="1794" reactomeId="2022135" position="224 109" bounds="203 94 43 31" textPosition="207 98" /> <org.gk.render.RenderableChemical id="1796" reactomeId="2022135" position="532 36" bounds="511 21 43 31" textPosition="515 25" /> <org.gk.render.RenderableChemical id="1798" reactomeId="352327" position="64 41" bounds="47 26 34 31" textPosition="51 30" /> <org.gk.render.RenderableChemical id="1800" reactomeId="352327" position="406 112" bounds="389 97 34 31" textPosition="393 101" /> <org.gk.render.RenderableChemical id="1802" reactomeId="351626" position="522 118" bounds="504 103 36 31" textPosition="508 107" /> <org.gk.render.RenderableComplex id="1853" reactomeId="5696086" position="8772 1683" bounds="8713 1672 118 23" textPosition="8713 1673" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ALDH1B1 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1862" reactomeId="29356" position="4866 1260" bounds="4845 1245 43 31" textPosition="4849 1249" /> <org.gk.render.RenderableChemical id="1863" reactomeId="5689006" position="4830 1295" bounds="4806 1280 49 31" textPosition="4810 1284"> <Properties> <displayName>PHEN</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1864" reactomeId="5689001" position="4995 1259" bounds="4951 1244 88 31" textPosition="4955 1248"> <Properties> <displayName>acetyl group</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1865" reactomeId="5688995" position="5057 1295" bounds="5004 1280 107 31" textPosition="5008 1284"> <Properties> <displayName>4-ethoxyaniline</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1866" reactomeId="5688919" position="4921 1363" bounds="4896 1352 50 23" textPosition="4896 1352"> <Properties> <displayName>AADAC</displayName> </Properties> </org.gk.render.RenderableProtein> 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</Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1881" reactomeId="6786175" position="5069 250" bounds="5051 235 36 31" textPosition="5055 239"> <Properties> <displayName>OM</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1882" reactomeId="29356" position="5097 285" bounds="5076 270 43 31" textPosition="5080 274" /> <org.gk.render.RenderableChemical id="1883" reactomeId="6786179" position="5241 294" bounds="5208 279 67 31" textPosition="5212 283"> <Properties> <displayName>diketone</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1885" reactomeId="6786204" position="5168 200" bounds="5148 189 40 23" textPosition="5148 189"> <Properties> <displayName>CMBL</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="2389" reactomeId="6786220" position="5238 1362" bounds="5217 1347 43 31" textPosition="5221 1351"> <Properties> <displayName>DHA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2390" reactomeId="6786225" position="5452 1364" bounds="5423 1349 58 31" textPosition="5427 1353"> <Properties> <displayName>HDoHE</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2391" reactomeId="29356" position="5446 1414" bounds="5425 1399 43 31" textPosition="5429 1403" /> <org.gk.render.RenderableProtein id="2392" reactomeId="6786215" position="5340 1366" bounds="5313 1355 55 23" textPosition="5313 1355"> <Properties> <displayName>CYP4V2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="2394" reactomeId="70106" position="5212 1448" bounds="5194 1433 36 31" textPosition="5198 1437" /> <org.gk.render.RenderableChemical id="2396" reactomeId="29364" position="5223 1410" bounds="5194 1395 59 31" textPosition="5198 1399" /> 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fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>DEXM</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableChemicalDrug id="2609" reactomeId="76455" position="3255 596" bounds="3231 581 49 31" textPosition="3235 585" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>DEXT</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableChemical id="2611" reactomeId="143501" position="3268 643" bounds="3243 628 51 31" textPosition="3247 632" /> <org.gk.render.RenderableChemical id="2613" reactomeId="29532" position="7986 1093" bounds="7969 1078 35 31" textPosition="7973 1082"> <Properties> <displayName>Fru</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="2617" reactomeId="9677913" position="8211 1536" bounds="8161 1525 100 23" textPosition="8161 1525" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>MAOB Inhibitors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2618" reactomeId="9677922" position="8363 1440" bounds="8307 1422 112 37" textPosition="8307 1423" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>MAOB:FAD:MAOB Inhibitors</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="2622" reactomeId="9677898" position="8379 904" bounds="8329 893 101 23" textPosition="8329 893" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>MAOA Inhibitors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2624" reactomeId="9677899" position="8324 1022" bounds="8267 1004 114 37" textPosition="8267 1005" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> 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bounds="3163 316 43 31" textPosition="3167 320" /> <org.gk.render.RenderableChemical id="2822" reactomeId="70106" position="3170 289" bounds="3152 274 36 31" textPosition="3156 278" /> <org.gk.render.RenderableChemical id="2823" reactomeId="9915557" position="2210 1199" bounds="2156 1184 109 31" textPosition="2160 1188"> <Properties> <displayName>hydrogen donor</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2824" reactomeId="113519" position="2370 1315" bounds="2349 1300 43 31" textPosition="2353 1304" /> <org.gk.render.RenderableChemical id="2825" reactomeId="9915551" position="2362 1231" bounds="2300 1216 125 31" textPosition="2304 1220"> <Properties> <displayName>hydrogen acceptor</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2833" reactomeId="70106" position="7742 387" bounds="7724 372 36 31" textPosition="7728 376" /> <org.gk.render.RenderableChemical id="2835" reactomeId="422019" position="1251 497" bounds="1226 481 50 33" textPosition="1231 486"> <Properties> <displayName>DECA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2836" reactomeId="9971242" position="1498 495" bounds="1458 479 80 33" textPosition="1470 478" /> <org.gk.render.RenderableChemical id="2837" reactomeId="113519" position="1567 555" bounds="1542 539 50 33" textPosition="1550 544" /> <org.gk.render.RenderableEntity id="2838" reactomeId="9971238" position="1355 426" bounds="1288 402 134 49" textPosition="1287 402"> <Properties> <displayName>Unknown Cytochrome P450-like monooxygenase</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableChemical id="2843" reactomeId="113564" position="1410 534" bounds="1380 519 60 31" textPosition="1384 523" /> <org.gk.render.RenderableChemical id="2845" reactomeId="113534" position="1260 535" bounds="1243 520 34 31" textPosition="1247 524" /> 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dehydrogenase</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableChemical id="2874" reactomeId="73473" position="5832 1767" bounds="5806 1752 52 31" textPosition="5810 1756"> <Properties> <displayName>NADH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2876" reactomeId="29360" position="5653 1758" bounds="5627 1743 53 31" textPosition="5631 1747" /> <org.gk.render.RenderableChemical id="2878" reactomeId="70106" position="5848 1678" bounds="5830 1663 36 31" textPosition="5834 1667" /> <org.gk.render.RenderableProtein id="2879" reactomeId="192169" position="1709 432" bounds="1682 421 55 23" textPosition="1682 421" /> <org.gk.render.RenderableChemical id="2880" reactomeId="1131953" position="3796 307" bounds="3742 292 109 31" textPosition="3746 296" /> <org.gk.render.RenderableChemical id="2881" reactomeId="1130886" position="4077 302" bounds="4015 287 125 31" textPosition="4019 291" /> 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334" /> <Input id="653" points="759 298" /> <Input id="655" points="754 350" /> <Input id="657" points="798 296" /> </Inputs> <Outputs> <Output id="625" points="644 353" /> <Output id="626" points="614 334" /> <Output id="659" points="621 310" /> </Outputs> <Catalysts> <Catalyst id="912" points="697 405" /> </Catalysts> <Properties> <displayName>CYP4F2, 4F3 20-hydroxylate LTB4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="493" reactomeId="192061" points="4293 343, 4335 342, 4401 343" position="4335 342" lineWidth="1.0"> <Inputs> <Input id="90" points="4238 343" /> <Input id="99" points="4255 281" /> <Input id="108" points="4255 316" /> <Input id="115" points="4215 414" /> </Inputs> <Outputs> <Output id="75" points="4494 343" /> <Output id="84" points="4485 304" /> <Output id="154" points="4475 416" /> </Outputs> <Catalysts> <Catalyst id="69" points="4335 410" /> </Catalysts> <Properties> <displayName>CYP46A1 24-hydroxylates CHOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="494" reactomeId="193997" points="9041 1182, 9092 1181, 9130 1182" position="9092 1181" lineWidth="1.0"> <Inputs> <Input id="138" stoichiometry="2" points="8990 1245" /> <Input id="67" points="9004 1182" /> <Input id="141" stoichiometry="2" points="9000 1149" /> <Input id="145" points="8979 1216" /> </Inputs> <Outputs> <Output id="38" points="9178 1180" /> <Output id="2800" points="9169 1152" /> <Output id="151" stoichiometry="2" points="9179 1219" /> </Outputs> <Catalysts> <Catalyst id="771" points="9091 1130" /> </Catalysts> <Activators> <Activator id="630" points="9092 1220" /> </Activators> <Properties> <displayName>CYP11B1 oxidises 11DCORT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="495" reactomeId="192051" points="1640 362, 1706 363, 1827 362" position="1706 363" lineWidth="1.0"> <Inputs> <Input id="59" points="1602 362" /> <Input id="89" points="1594 292" /> <Input id="100" points="1644 293" /> <Input id="109" points="1586 328" /> </Inputs> <Outputs> <Output id="52" points="1871 368" /> <Output id="74" points="1897 308" /> <Output id="85" points="1926 330" /> </Outputs> <Catalysts> <Catalyst id="2879" points="1708 418" /> </Catalysts> <Inhibitors> <Inhibitor id="1036" points="1923 235" /> </Inhibitors> <Properties> <displayName>CYP7A1 7-hydroxylates CHOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="496" reactomeId="193964" points="3416 369, 3464 369, 3515 368" position="3464 369" lineWidth="1.0"> <Inputs> <Input id="35" points="3321 336" /> <Input id="94" points="3360 387" /> <Input id="101" points="3322 368" /> <Input id="106" points="3354 309" /> </Inputs> <Outputs> <Output id="26" points="3571 366" /> <Output id="73" points="3551 305" /> <Output id="88" points="3587 333" /> </Outputs> <Catalysts> <Catalyst id="68" points="3464 416" /> </Catalysts> <Properties> <displayName>CYP21A2 21-hydroxylates PROG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="497" reactomeId="192178" points="3814 364, 3896 365, 3962 366" position="3896 365" lineWidth="1.0"> <Inputs> <Input id="2880" points="3748 365" /> <Input id="42" points="3800 326" /> <Input id="2889" points="3793 414" /> </Inputs> <Outputs> <Output id="2881" points="4055 369" /> <Output id="2882" points="4049 321" /> <Output id="53" points="3943 323" /> <Output id="2887" points="4040 415" /> </Outputs> <Catalysts> <Catalyst id="66" points="3896 420" /> </Catalysts> <Properties> <displayName>CYP39A1 7-hydroxylates 24OH-CHOL</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="498" reactomeId="211951" points="6662 1471, 6689 1470, 6721 1470" position="6689 1470" lineWidth="1.0"> <Inputs> <Input id="24" points="6598 1423" /> <Input id="31" points="6641 1422" /> <Input id="46" points="6622 1470" /> <Input id="30" points="6547 1429" /> </Inputs> <Outputs> <Output id="49" points="6739 1445" /> <Output id="65" points="6779 1443" /> <Output id="47" points="6766 1470" /> </Outputs> <Catalysts> <Catalyst id="58" points="6690 1384" /> </Catalysts> <Inhibitors> <Inhibitor id="2594" points="6748 1673" /> </Inhibitors> <Activators> <Activator id="2522" points="6837 1722" /> </Activators> <Properties> <displayName>CYP1B1 4-hydroxylates EST17b</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="499" reactomeId="192065" points="2128 358, 2188 358, 2266 358" position="2188 358" lineWidth="1.0"> <Inputs> <Input id="27" points="2069 306" /> <Input id="92" points="2089 357" /> <Input id="104" points="2114 261" /> <Input id="105" points="2146 303" /> </Inputs> <Outputs> <Output id="29" points="2329 358" /> <Output id="80" points="2330 320" /> <Output id="81" points="2304 288" /> </Outputs> <Catalysts> <Catalyst id="660" points="2190 410" /> </Catalysts> <Inhibitors> <Inhibitor id="1036" points="2030 206, 2187 208" /> </Inhibitors> <Properties> <displayName>CYP7B1 7-hydroxylates 25OH-CHOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="500" reactomeId="194678" points="4690 363, 4726 368, 4768 368" position="4726 368" lineWidth="1.0"> <Inputs> <Input id="32" points="4628 411" /> <Input id="96" stoichiometry="3" points="4641 331" /> <Input id="102" stoichiometry="3" points="4647 362" /> <Input id="110" stoichiometry="3" points="4666 305" /> </Inputs> <Outputs> <Output id="36" points="4864 418" /> <Output id="78" stoichiometry="4" points="4854 302" /> <Output id="83" stoichiometry="3" points="4865 332" /> <Output id="153" points="4845 364" /> </Outputs> <Catalysts> <Catalyst id="45" points="4723 423" /> </Catalysts> <Properties> <displayName>CYP51A1 demethylates LAN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="501" reactomeId="192123" points="8770 1389, 8796 1388, 8828 1389" position="8796 1388" lineWidth="1.0"> <Inputs> <Input id="43" points="8704 1391" /> <Input id="139" points="8732 1360" /> <Input id="142" points="8723 1418" /> <Input id="144" points="8757 1421" /> </Inputs> <Outputs> <Output id="71" points="8863 1389" /> <Output id="148" points="8864 1422" /> <Output id="150" points="8871 1356" /> </Outputs> <Catalysts> <Catalyst id="61" points="8796 1335" /> </Catalysts> <Properties> <displayName>CYP27A1 27-hydroxylates CHOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="502" reactomeId="193101" points="8599 1193, 8647 1193, 8718 1194" position="8647 1193" lineWidth="1.0"> <Inputs> <Input id="50" points="8505 1164" /> <Input id="37" points="8484 1128" /> <Input id="1134" stoichiometry="2" points="8599 1115" /> <Input id="1232" stoichiometry="2" points="8529 1242" /> <Input id="1223" stoichiometry="2" points="8522 1203" /> </Inputs> <Outputs> <Output id="1135" stoichiometry="2" points="8758 1122" /> <Output id="40" points="8831 1189" /> <Output id="70" points="8805 1151" /> <Output id="1221" stoichiometry="2" points="8726 1241" /> <Output id="1225" stoichiometry="2" points="8780 1220" /> </Outputs> <Catalysts> <Catalyst id="1134" points="8607 1115" /> </Catalysts> <Properties> <displayName>CYP11A1 cleaves 20a,22b-DHCHOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="505" reactomeId="193060" points="2954 373, 2991 373, 3026 374" position="2991 373" lineWidth="1.0"> <Inputs> <Input id="63" points="2889 370" /> <Input id="111" stoichiometry="3" points="2938 272" /> <Input id="98" stoichiometry="3" points="2885 288" /> <Input id="95" stoichiometry="3" points="2864 323" /> </Inputs> <Outputs> <Output id="57" points="3044 274" /> <Output id="25" points="3170 373" /> <Output id="2820" stoichiometry="4" points="3160 336" /> <Output id="2822" stoichiometry="4" points="3149 299" /> <Output id="87" stoichiometry="3" points="3110 271" /> </Outputs> <Catalysts> <Catalyst id="62" points="2991 417" /> </Catalysts> <Properties> <displayName>CYP19A1 hydroxylates ANDST to E1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="506" reactomeId="193845" points="226 1123, 226 1213, 225 1259" position="226 1213" lineWidth="1.0"> <Inputs> <Input id="116" points="178 1126" /> <Input id="121" points="158 1155" /> <Input id="123" points="152 1098" /> <Input id="127" points="228 1083" /> </Inputs> <Outputs> <Output id="2566" points="226 1290" /> <Output id="135" points="161 1285" /> <Output id="136" points="165 1255" /> </Outputs> <Catalysts> <Catalyst id="2732" points="425 1346" /> </Catalysts> <Properties> <displayName>CYP8B1 12-hydroxylates 4CHOL7a,27DONE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="507" reactomeId="193709" points="109 792, 109 877, 107 950" position="109 877" lineWidth="1.0"> <Inputs> <Input id="125" points="176 805" /> <Input id="128" points="75 774" /> <Input id="130" points="142 776" /> <Input id="132" points="111 756" /> </Inputs> <Outputs> <Output id="118" points="80 966" /> <Output id="122" points="174 979" /> <Output id="119" points="106 1017" /> </Outputs> <Catalysts> <Catalyst id="2732" points="437 1346, 265 879" /> </Catalysts> <Properties> <displayName>CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="508" reactomeId="192157" points="397 1415, 442 1414, 494 1415" position="442 1414" lineWidth="1.0"> <Inputs> <Input id="124" points="335 1373" /> <Input id="129" points="315 1407" /> <Input id="131" points="309 1438" /> <Input id="133" points="383 1441" /> </Inputs> <Outputs> <Output id="120" points="558 1374" /> <Output id="134" points="539 1423" /> <Output id="137" points="513 1437" /> </Outputs> <Catalysts> <Catalyst id="2732" points="442 1375" /> </Catalysts> <Properties> <displayName>CYP8B1 12-hydroxylates 4CHOL7aOLONE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="509" reactomeId="211983" points="1284 671, 1342 671, 1397 670" position="1342 671" lineWidth="1.0"> <Inputs> <Input id="155" points="1216 710" /> <Input id="159" points="1206 638" /> <Input id="160" points="1230 621" /> <Input id="161" points="1187 673" /> </Inputs> <Outputs> <Output id="156" points="1464 700" /> <Output id="157" points="1461 669" /> <Output id="162" points="1448 643" /> </Outputs> <Catalysts> <Catalyst id="893" points="1340 630" /> </Catalysts> <Properties> <displayName>CYP2J2 oxidises ARA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="510" reactomeId="76466" points="520 914, 578 913, 633 913" position="578 913" lineWidth="1.0"> <Inputs> <Input id="163" points="432 883" /> <Input id="174" points="476 854" /> <Input id="179" points="478 937" /> <Input id="183" points="433 915" /> </Inputs> <Outputs> <Output id="164" points="744 904" /> <Output id="165" points="693 869" /> <Output id="176" points="674 951" /> </Outputs> <Catalysts> <Catalyst id="937" points="578 877" /> </Catalysts> <Properties> <displayName>CYP4A11 omega-hydroxylates DDCX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="511" reactomeId="211924" points="1460 837, 1509 836, 1563 837" position="1509 836" lineWidth="1.0"> <Inputs> <Input id="155" points="1216 726" /> <Input id="175" points="1423 793" /> <Input id="180" points="1426 836" /> <Input id="182" points="1437 854" /> </Inputs> <Outputs> <Output id="167" points="1628 883" /> <Output id="168" points="1658 838" /> <Output id="177" points="1620 798" /> </Outputs> <Catalysts> <Catalyst id="759" points="1514 794" /> </Catalysts> <Properties> <displayName>CYP4B1 12-hydroxylates ARA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="512" reactomeId="211904" points="1059 934, 1154 934, 1228 934" position="1154 934" lineWidth="1.0"> <Inputs> <Input id="155" points="1186 738" /> <Input id="173" points="1024 965" /> <Input id="181" points="1016 905" /> <Input id="184" points="1014 934" /> </Inputs> <Outputs> <Output id="170" points="1264 967" /> <Output id="171" points="1315 936" /> <Output id="178" points="1266 909" /> </Outputs> <Catalysts> <Catalyst id="1014" points="1155 984" /> </Catalysts> <Properties> <displayName>CYP4F12 18-hydroxylates ARA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="513" reactomeId="211910" points="4259 1034, 4314 1034, 4366 1034" position="4314 1034" lineWidth="1.0"> <Inputs> <Input id="223" points="4178 1034" /> <Input id="194" points="4150 1001" /> <Input id="230" points="4214 1056" /> <Input id="238" points="4205 1004" /> </Inputs> <Outputs> <Output id="198" points="4438 1034" /> <Output id="209" points="4405 1059" /> <Output id="271" points="4394 1011" /> </Outputs> <Catalysts> <Catalyst id="686" points="4310 967" /> </Catalysts> <Properties> <displayName>CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="514" reactomeId="211966" points="3039 775, 3087 776, 3148 775" position="3087 776" lineWidth="1.0"> <Inputs> <Input id="200" points="2934 801" /> <Input id="227" points="2913 757" /> <Input id="239" points="2919 720" /> <Input id="255" points="2918 671" /> </Inputs> <Outputs> <Output id="197" points="3199 796" /> <Output id="270" points="3231 711" /> <Output id="281" points="3218 762" /> </Outputs> <Catalysts> <Catalyst id="706" points="3086 742" /> </Catalysts> <Properties> <displayName>CYP2D6 4-hydroxylates debrisoquine</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="515" reactomeId="213175" points="4519 748, 4570 748, 4621 749" position="4570 748" lineWidth="1.0"> <Inputs> <Input id="212" points="4416 748" /> <Input id="204" points="4470 708" /> <Input id="237" points="4461 776" /> <Input id="253" points="4425 715" /> </Inputs> <Outputs> <Output id="226" points="4695 749" /> <Output id="267" points="4666 782" /> <Output id="272" points="4660 714" /> </Outputs> <Catalysts> <Catalyst id="812" points="4570 698" /> </Catalysts> <Properties> <displayName>CYP3A4,5 oxidise AFB1 to AFXBO</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="516" reactomeId="212005" points="2515 756, 2550 757, 2602 757" position="2550 757" lineWidth="1.0"> <Inputs> <Input id="207" points="2425 759" /> <Input id="229" points="2472 799" /> <Input id="244" points="2439 731" /> <Input id="249" points="2424 794" /> </Inputs> <Outputs> <Output id="215" points="2674 754" /> <Output id="268" points="2664 790" /> <Output id="273" points="2643 731" /> </Outputs> <Catalysts> <Catalyst id="839" points="2549 715" /> </Catalysts> <Properties> <displayName>CYP2F1 dehydrogenates 3-methylindole</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="517" reactomeId="211991" points="1958 681, 2028 681, 2083 682" position="2028 681" lineWidth="1.0"> <Inputs> <Input id="199" points="1869 682" /> <Input id="236" points="1906 656" /> <Input id="246" points="1915 701" /> <Input id="258" points="1949 708" /> </Inputs> <Outputs> <Output id="191" points="2138 683" /> <Output id="264" points="2119 709" /> <Output id="278" points="2135 657" /> </Outputs> <Catalysts> <Catalyst id="793" points="2028 638" /> </Catalysts> <Properties> <displayName>Cyclophosphamide is 4-hydroxylated by CYP2B6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="518" reactomeId="76472" points="7074 1197, 7104 1197, 7140 1197" position="7104 1197" lineWidth="1.0"> <Inputs> <Input id="218" points="6970 1231" /> <Input id="201" points="6994 1197" /> <Input id="248" points="7029 1238" /> <Input id="259" points="6988 1166" /> </Inputs> <Outputs> <Output id="208" points="7205 1199" /> <Output id="265" points="7195 1226" /> <Output id="280" points="7172 1180" /> </Outputs> <Catalysts> <Catalyst id="192" points="7104 1160" /> </Catalysts> <Inhibitors> <Inhibitor id="2594" points="6760 1673" /> </Inhibitors> <Activators> <Activator id="2522" points="6849 1722" /> </Activators> <Properties> <displayName>Ethylene is oxidized to Ethylene oxide by CYP1A1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="519" reactomeId="212004" points="4706 1027, 4750 1027, 4794 1027" position="4750 1027" lineWidth="1.0"> <Inputs> <Input id="213" points="4645 1027" /> <Input id="231" points="4656 1053" /> <Input id="242" points="4655 1004" /> <Input id="251" points="4646 977" /> </Inputs> <Outputs> <Output id="225" points="4895 1027" /> <Output id="263" points="4847 1050" /> <Output id="274" points="4845 1003" /> </Outputs> <Catalysts> <Catalyst id="857" points="4750 982" /> </Catalysts> <Properties> <displayName>CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="520" reactomeId="211929" points="3645 988, 3692 988, 3745 988" position="3692 988" lineWidth="1.0"> <Inputs> <Input id="210" points="3571 989" /> <Input id="232" points="3609 952" /> <Input id="241" points="3611 1003" /> <Input id="250" points="3565 959" /> </Inputs> <Outputs> <Output id="220" points="3847 988" /> <Output id="269" points="3782 1008" /> <Output id="276" points="3791 965" /> </Outputs> <Catalysts> <Catalyst id="874" points="3692 941" /> </Catalysts> <Properties> <displayName>CYP2C19 5-hydroxylates omeprazole</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="521" reactomeId="211882" points="4044 759, 4091 758, 4138 759" position="4091 758" lineWidth="1.0"> <Inputs> <Input id="186" points="3968 759" /> <Input id="234" points="3996 732" /> <Input id="245" points="4011 776" /> <Input id="254" points="4029 803" /> </Inputs> <Outputs> <Output id="189" points="4228 755" /> <Output id="221" points="4185 732" /> <Output id="260" points="4166 778" /> </Outputs> <Catalysts> <Catalyst id="838" points="4091 707" /> </Catalysts> <Properties> <displayName>CYP3A7 can 6beta-hydroxylate testosterone</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="522" reactomeId="76453" points="1979 989, 2049 989, 2124 989" position="2049 989" lineWidth="1.0"> <Inputs> <Input id="206" points="1854 947" /> <Input id="247" points="1937 957" /> <Input id="257" points="2011 957" /> <Input id="235" points="1979 960" /> </Inputs> <Outputs> <Output id="222" points="2262 944" /> <Output id="266" points="2165 960" /> <Output id="279" points="2120 956" /> </Outputs> <Catalysts> <Catalyst id="724" points="2049 1023" /> </Catalysts> <Properties> <displayName>Coumarin is 7-hydroxylated by CYP2A6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="523" reactomeId="211988" points="3134 1002, 3196 1003, 3236 1003" position="3196 1003" lineWidth="1.0"> <Inputs> <Input id="2701" points="3047 1003" /> <Input id="256" points="3045 971" /> <Input id="243" points="3103 1019" /> <Input id="233" points="3099 970" /> </Inputs> <Outputs> <Output id="185" points="3310 1003" /> <Output id="262" points="3301 1037" /> <Output id="277" points="3297 971" /> </Outputs> <Catalysts> <Catalyst id="740" points="3198 963" /> </Catalysts> <Properties> <displayName>CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="524" reactomeId="211881" points="1968 896, 2044 896, 2134 896" position="2044 896" lineWidth="1.0"> <Inputs> <Input id="206" points="1854 931" /> <Input id="235" points="1975 923" /> <Input id="247" points="1937 920" /> <Input id="257" points="2011 929" /> </Inputs> <Outputs> <Output id="222" points="2262 930" /> <Output id="266" points="2168 923" /> <Output id="279" points="2124 919" /> </Outputs> <Catalysts> <Catalyst id="968" points="2044 862" /> </Catalysts> <Properties> <displayName>Coumarin is 7-hydroxylated by CYP2A13</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="525" reactomeId="211948" points="3586 750, 3623 749, 3674 751" position="3623 749" lineWidth="1.0"> <Inputs> <Input id="216" points="3485 750" /> <Input id="228" points="3514 704" /> <Input id="240" points="3537 768" /> <Input id="252" points="3473 718" /> </Inputs> <Outputs> <Output id="188" points="3725 751" /> <Output id="261" points="3711 776" /> <Output id="275" points="3721 724" /> </Outputs> <Catalysts> <Catalyst id="1035" points="3623 706" /> </Catalysts> <Properties> <displayName>CYP3A4 can N-demethylate loperamide</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="526" reactomeId="76426" points="5123 503, 5170 503, 5223 503" position="5170 503" lineWidth="1.0"> <Inputs> <Input id="282" points="5057 501" /> <Input id="283" points="5027 538" /> <Input id="289" points="5063 555" /> <Input id="290" points="5082 473" /> </Inputs> <Outputs> <Output id="287" points="5322 561" /> <Output id="284" points="5265 561" /> <Output id="285" points="5289 490" /> <Output id="286" points="5298 520" /> </Outputs> <Catalysts> <Catalyst id="292" points="5170 439" /> </Catalysts> <Properties> <displayName>N-atom dealkylation of caffeine</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="527" reactomeId="76373" points="5546 499, 5608 499, 5654 499" position="5608 499" lineWidth="1.0"> <Inputs> <Input id="291" points="5506 481" /> <Input id="295" points="5495 505" /> <Input id="296" points="5519 536" /> <Input id="297" points="5473 533" /> </Inputs> <Outputs> <Output id="288" points="5726 499" /> <Output id="293" points="5686 478" /> <Output id="294" points="5703 526" /> </Outputs> <Catalysts> <Catalyst id="292" points="5201 424, 5607 427" /> </Catalysts> <Properties> <displayName>N-hydroxylation of 4-aminobiphenyl</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="528" reactomeId="76354" points="6194 859, 6245 857, 6299 857" position="6245 857" lineWidth="1.0"> <Inputs> <Input id="306" points="6171 882" /> <Input id="311" points="6117 865" /> <Input id="323" points="6119 829" /> <Input id="336" points="6169 837" /> </Inputs> <Outputs> <Output id="299" points="6384 864" /> <Output id="328" points="6348 890" /> <Output id="333" points="6357 834" /> </Outputs> <Catalysts> <Catalyst id="663" points="6251 454" /> </Catalysts> <Properties> <displayName>Vinyl chloride is oxidized to 2-Chloroethylene oxide</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="529" reactomeId="76397" points="5960 507, 5988 507, 6023 506" position="5988 507" lineWidth="1.0"> <Inputs> <Input id="309" points="5890 512" /> <Input id="300" points="5923 573" /> <Input id="319" points="5934 491" /> <Input id="330" points="5905 535" /> </Inputs> <Outputs> <Output id="316" points="6062 519" /> <Output id="318" points="6023 535" /> <Output id="329" points="6055 492" /> </Outputs> <Catalysts> <Catalyst id="663" points="6188 437, 5986 469" /> </Catalysts> <Properties> <displayName>Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="530" reactomeId="76416" points="6408 612, 6436 610, 6465 610" position="6436 610" lineWidth="1.0"> <Inputs> <Input id="313" points="6372 659" /> <Input id="308" points="6382 591" /> <Input id="320" points="6314 602" /> <Input id="325" points="6372 624" /> </Inputs> <Outputs> <Output id="303" points="6491 588" /> <Output id="314" points="6503 657" /> <Output id="310" points="6492 616" /> </Outputs> <Catalysts> <Catalyst id="663" points="6270 454" /> </Catalysts> <Properties> <displayName>Benzene is hydroxylated to phenol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="532" reactomeId="76475" points="6669 781, 6620 682, 6717 680" position="6620 682" lineWidth="1.0"> <Inputs> <Input id="298" points="6658 836" /> <Input id="321" points="6736 839" /> <Input id="322" points="6588 815" /> <Input id="334" points="6620 832" /> </Inputs> <Outputs> <Output id="302" points="6802 661" /> <Output id="312" points="6825 703" /> <Output id="327" points="6749 648" /> <Output id="332" points="6726 607" /> </Outputs> <Catalysts> <Catalyst id="663" points="6316 444, 6539 506" /> </Catalysts> <Properties> <displayName>Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="533" reactomeId="76434" points="6641 503, 6706 502, 6759 502" position="6706 502" lineWidth="1.0"> <Inputs> <Input id="304" /> </Inputs> <Outputs> <Output id="307" points="6820 504" /> <Output id="305" points="6791 531" /> </Outputs> <Catalysts> <Catalyst id="663" points="6316 434, 6704 468" /> </Catalysts> <Properties> <displayName>Dehalogenation of carbon tetrachloride to form a free radical</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="534" reactomeId="209845" points="7886 1319, 7886 1272, 7886 1224" position="7886 1272" lineWidth="1.0"> <Inputs> <Input id="2563" points="7886 1371" /> <Input id="341" points="7855 1333" /> <Input id="342" points="7926 1362" /> <Input id="343" points="7922 1333" /> </Inputs> <Outputs> <Output id="2564" points="7886 1161" /> <Output id="2565" points="7903 1211" /> <Output id="344" points="7855 1203" /> </Outputs> <Catalysts> <Catalyst id="340" points="7812 1272" /> </Catalysts> <Properties> <displayName>CYP2R1 25-hydroxylates VD3 to 25(OH)D</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="535" reactomeId="211950" points="9444 1605, 9486 1605, 9534 1604" position="9486 1605" lineWidth="1.0"> <Inputs> <Input id="345" points="9314 1605" /> <Input id="361" points="9371 1639" /> <Input id="362" points="9402 1581" /> <Input id="363" points="9407 1653" /> </Inputs> <Outputs> <Output id="346" points="9584 1640" /> <Output id="347" points="9626 1604" /> <Output id="360" points="9576 1582" /> </Outputs> <Catalysts> <Catalyst id="348" points="9486 1700" /> </Catalysts> <Properties> <displayName>CYP24A1 24-hydroxylates CTL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="536" reactomeId="209868" points="8067 1054, 8068 1092, 8069 1127" position="8068 1092" lineWidth="1.0"> <Inputs> <Input id="339" points="8015 1042" /> <Input id="373" points="8046 1028" /> <Input id="375" points="8067 991" /> <Input id="374" points="8092 1027" /> </Inputs> <Outputs> <Output id="349" points="8069 1200" /> <Output id="376" points="8044 1154" /> <Output id="377" points="8095 1156" /> </Outputs> <Catalysts> <Catalyst id="350" points="8220 1092" /> </Catalysts> <Inhibitors> <Inhibitor id="2613" points="8007 1092" /> </Inhibitors> <Properties> <displayName>CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="539" reactomeId="212007" points="7306 519, 7281 515, 7280 612" position="7281 515" lineWidth="1.0"> <Inputs> <Input id="355" points="7428 618" /> <Input id="370" points="7369 530" /> <Input id="368" points="7380 477" /> <Input id="364" points="7414 505" /> </Inputs> <Outputs> <Output id="356" points="7366 794" /> <Output id="357" points="7249 669" /> <Output id="366" points="7246 626" /> </Outputs> <Catalysts> <Catalyst id="1041" points="7282 447" /> </Catalysts> <Properties> <displayName>CYP26A1,B1 4-hydroxylate atRA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="540" reactomeId="211874" points="7595 635, 7704 635, 7704 728" position="7704 635" lineWidth="1.0"> <Inputs> <Input id="397" points="7563 588" /> <Input id="409" points="7619 585" /> <Input id="415" points="7589 550" /> <Input id="355" points="7472 635" /> </Inputs> <Outputs> <Output id="378" points="7621 771" /> <Output id="404" points="7675 781" /> <Output id="356" points="7416 802" /> </Outputs> <Catalysts> <Catalyst id="676" points="7754 633" /> </Catalysts> <Properties> <displayName>CYP2S1 4-hydroxylates atRA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="541" reactomeId="211960" points="3148 1255, 3199 1254, 3263 1254" position="3199 1254" lineWidth="1.0"> <Inputs> <Input id="395" points="3080 1255" /> <Input id="398" points="3081 1221" /> <Input id="406" points="3114 1201" /> <Input id="413" points="3117 1280" /> </Inputs> <Outputs> <Output id="380" points="3299 1279" /> <Output id="381" points="3365 1254" /> <Output id="403" points="3293 1234" /> </Outputs> <Catalysts> <Catalyst id="697" points="3197 1195" /> </Catalysts> <Properties> <displayName>CYP2U1 19-hydroxylates ARA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="542" reactomeId="211968" points="3637 1250, 3707 1250, 3766 1250" position="3707 1250" lineWidth="1.0"> <Inputs> <Input id="383" points="3544 1252" /> <Input id="396" points="3576 1277" /> <Input id="410" points="3546 1223" /> <Input id="412" points="3601 1216" /> </Inputs> <Outputs> <Output id="384" points="3802 1227" /> <Output id="385" points="3825 1250" /> <Output id="401" points="3805 1270" /> </Outputs> <Catalysts> <Catalyst id="988" points="3706 1334" /> </Catalysts> <Properties> <displayName>CYP2W1 oxidises INDOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="543" reactomeId="211959" points="5794 1159, 5858 1159, 5916 1159" position="5858 1159" lineWidth="1.0"> <Inputs> <Input id="393" points="5716 1158" /> <Input id="400" points="5752 1191" /> <Input id="407" points="5717 1126" /> <Input id="411" points="5758 1112" /> </Inputs> <Outputs> <Output id="387" points="5971 1128" /> <Output id="394" points="6023 1159" /> <Output id="402" points="5958 1188" /> </Outputs> <Catalysts> <Catalyst id="678" points="5853 1050" /> </Catalysts> <Properties> <displayName>CYP3A43 6b-hydroxylates TEST</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="544" reactomeId="211962" points="7626 1077, 7678 1077, 7734 1077" position="7678 1077" lineWidth="1.0"> <Inputs> <Input id="389" points="7577 1106" /> <Input id="399" points="7582 1077" /> <Input id="408" points="7616 1032" /> <Input id="414" points="7580 1010" /> </Inputs> <Outputs> <Output id="390" points="7697 1176" /> <Output id="391" points="7747 1109" /> <Output id="405" points="7692 1115" /> </Outputs> <Catalysts> <Catalyst id="1003" points="7732 1033" /> </Catalysts> <Properties> <displayName>CYP4F11 16-hydroxylates 3OH-PALM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="545" reactomeId="217255" points="1222 1290, 1270 1292, 1315 1292" position="1270 1292" lineWidth="1.0"> <Inputs> <Input id="2648" points="1148 1294" /> <Input id="432" points="1165 1239" /> <Input id="434" points="1194 1306" /> <Input id="431" points="1138 1259" /> </Inputs> <Outputs> <Output id="420" points="1389 1291" /> <Output id="437" points="1355 1315" /> <Output id="438" points="1351 1275" /> </Outputs> <Catalysts> <Catalyst id="429" points="1270 1347" /> </Catalysts> <Properties> <displayName>FMO1:FAD N-oxidises TAM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="546" reactomeId="217258" points="1630 1270, 1684 1271, 1754 1270" position="1684 1271" lineWidth="1.0"> <Inputs> <Input id="417" points="1556 1260" /> <Input id="430" points="1586 1286" /> <Input id="433" points="1514 1219" /> <Input id="435" points="1590 1213" /> </Inputs> <Outputs> <Output id="425" points="1818 1268" /> <Output id="436" points="1798 1298" /> <Output id="439" points="1798 1247" /> </Outputs> <Catalysts> <Catalyst id="426" points="1684 1350" /> </Catalysts> <Properties> <displayName>FMO2:FAD:Mg2+ S-oxidises MTZ</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="547" reactomeId="139970" points="802 1295, 856 1294, 904 1295" position="856 1294" lineWidth="1.0"> <Inputs> <Input id="416" points="759 1258" /> <Input id="428" points="718 1261" /> <Input id="418" points="756 1318" /> <Input id="421" points="750 1294" /> </Inputs> <Outputs> <Output id="427" points="941 1268" /> <Output id="419" points="962 1290" /> <Output id="422" points="960 1323" /> </Outputs> <Catalysts> <Catalyst id="424" points="856 1351" /> </Catalysts> <Properties> <displayName>FMO3:FAD N-oxidises TMA to TMAO</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="548" reactomeId="140359" points="2253 1277, 2297 1278, 2331 1276" position="2297 1278" lineWidth="1.0"> <Inputs> <Input id="2823" points="2218 1218" /> <Input id="441" points="2211 1277" /> </Inputs> <Outputs> <Output id="2824" points="2354 1297" /> <Output id="2825" points="2351 1250" /> <Output id="636" points="2364 1276" /> </Outputs> <Catalysts> <Catalyst id="632" points="2228 1348" /> </Catalysts> <Properties> <displayName>PGG2 is reduced to PGH2 by PTGS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="549" reactomeId="140355" points="2073 1273, 2121 1273, 2155 1275" position="2121 1273" lineWidth="1.0"> <Inputs> <Input id="440" stoichiometry="2" points="2027 1298" /> <Input id="444" points="2030 1246" /> </Inputs> <Outputs> <Output id="441" /> </Outputs> <Catalysts> <Catalyst id="632" points="2205 1348" /> </Catalysts> <Properties> <displayName>Arachidonate is oxidised to PGG2 by PTGS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="550" reactomeId="141200" points="8287 836, 8285 866, 8228 892" position="8285 866" lineWidth="1.0"> <Inputs> <Input id="463" points="8265 793" /> <Input id="461" points="8311 765" /> <Input id="459" points="8336 833" /> </Inputs> <Outputs> <Output id="464" points="8172 877" /> <Output id="457" points="8129 902" /> <Output id="455" points="8204 825" /> </Outputs> <Catalysts> <Catalyst id="448" points="8256 1346, 8196 1141, 8196 970" /> </Catalysts> <Properties> <displayName>MAOB:FAD oxidatively deaminates of PEA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="552" reactomeId="141202" points="8161 1322, 8161 1357, 8161 1385" position="8161 1357" lineWidth="1.0"> <Inputs> <Input id="454" points="8118 1314" /> <Input id="452" points="8161 1276" /> <Input id="449" points="8130 1289" /> </Inputs> <Outputs> <Output id="450" points="8137 1409" /> <Output id="453" points="8161 1458" /> <Output id="451" points="8188 1408" /> </Outputs> <Catalysts> <Catalyst id="448" points="8222 1358" /> </Catalysts> <Properties> <displayName>MAOB:FAD oxidatively deaminates TYR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="553" reactomeId="141351" points="8879 596, 8916 596, 8954 595" position="8916 596" lineWidth="1.0"> <Inputs> <Input id="469" points="8848 570" /> <Input id="485" points="8818 635" /> <Input id="487" points="8821 596" /> </Inputs> <Outputs> <Output id="477" points="9069 558" /> <Output id="480" points="9027 608" /> <Output id="481" points="8996 556" /> </Outputs> <Catalysts> <Catalyst id="478" points="8916 644" /> </Catalysts> <Properties> <displayName>PAOX:FAD oxidises NASPN to SPM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="554" reactomeId="141341" points="9237 658, 9289 659, 9359 659" position="9289 659" lineWidth="1.0"> <Inputs> <Input id="471" points="9197 661" /> <Input id="484" points="9203 633" /> <Input id="486" points="9210 693" /> </Inputs> <Outputs> <Output id="472" points="9422 629" /> <Output id="482" points="9401 683" /> <Output id="483" points="9446 657" /> </Outputs> <Catalysts> <Catalyst id="1220" points="9289 720" /> </Catalysts> <Properties> <displayName>SMOX-3 oxidises SPN to SPM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="555" reactomeId="141348" points="8867 724, 8917 723, 8961 723" position="8917 723" lineWidth="1.0"> <Inputs> <Input id="467" points="8821 709" /> <Input id="475" points="8799 737" /> <Input id="476" points="8825 757" /> </Inputs> <Outputs> <Output id="473" points="9019 688" /> <Output id="474" points="9020 775" /> <Output id="470" points="9052 725" /> </Outputs> <Catalysts> <Catalyst id="478" points="8917 673" /> </Catalysts> <Properties> <displayName>PAO:FAD oxidises NASPM to PTCN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="584" reactomeId="71691" points="7957 1642, 8042 1643, 8094 1642" position="8042 1643" lineWidth="1.0"> <Inputs> <Input id="563" points="7923 1664" /> <Input id="556" points="7971 1624" /> <Input id="577" points="7915 1642" /> </Inputs> <Outputs> <Output id="567" points="8131 1661" /> <Output id="573" points="8153 1763" /> <Output id="595" points="8146 1642" /> </Outputs> <Catalysts> <Catalyst id="571" points="8042 1687" /> </Catalysts> <Properties> <displayName>acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="585" reactomeId="71735" points="8080 1806, 8037 1806, 7989 1806" position="8037 1806" lineWidth="1.0"> <Inputs> <Input id="564" points="8135 1848" /> <Input id="559" points="8174 1825" /> <Input id="573" points="8121 1792" /> </Inputs> <Outputs> <Output id="565" points="7917 1808" /> <Output id="557" points="7948 1778" /> <Output id="581" points="7937 1838" /> </Outputs> <Catalysts> <Catalyst id="570" points="8037 1857" /> </Catalysts> <Properties> <displayName>acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="586" reactomeId="71723" points="8734 1606, 8773 1606, 8800 1606" position="8773 1606" lineWidth="1.0"> <Inputs> <Input id="558" points="8684 1569" /> <Input id="578" points="8660 1604" /> <Input id="561" points="8692 1651" /> </Inputs> <Outputs> <Output id="569" points="8897 1606" /> <Output id="560" points="8856 1580" /> <Output id="582" points="8841 1648" /> </Outputs> <Catalysts> <Catalyst id="566" points="8773 1548" /> </Catalysts> <Properties> <displayName>acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="587" reactomeId="449911" points="9008 1606, 9038 1606, 9067 1606" position="9038 1606" lineWidth="1.0"> <Inputs> <Input id="569" points="8978 1606" /> <Input id="575" points="8990 1620" /> <Input id="572" points="8990 1595" /> </Inputs> <Outputs> <Output id="568" points="9099 1607" /> <Output id="576" points="9086 1586" /> <Output id="583" points="9098 1634" /> </Outputs> <Catalysts> <Catalyst id="580" points="9038 1558" /> </Catalysts> <Properties> <displayName>acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="588" reactomeId="71707" points="7892 1562, 7921 1562, 7964 1563" position="7921 1562" lineWidth="1.0"> <Inputs> <Input id="574" points="7872 1546" /> <Input id="591" points="7877 1568" /> </Inputs> <Outputs> <Output id="562" points="8042 1556" /> <Output id="556" points="7975 1587" /> <Output id="593" points="8020 1527" /> </Outputs> <Catalysts> <Catalyst id="579" points="7922 1511" /> </Catalysts> <Properties> <displayName>ethanol + NAD+ => acetaldehyde + NADH + H+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="589" reactomeId="449872" points="8019 1604, 8445 1603, 8586 1603" position="8445 1603" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="556" /> </Inputs> <Outputs> <Output id="578" /> </Outputs> <Properties> <displayName>acetaldehyde [cytosolic] => acetaldehyde [mitochondrial]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="531" reactomeId="143468" points="6011 693, 6050 692, 6087 692" position="6050 692" lineWidth="1.0"> <Inputs> <Input id="315" points="5929 689" /> <Input id="622" points="5965 662" /> <Input id="324" points="5948 723" /> <Input id="335" points="6001 730" /> </Inputs> <Outputs> <Output id="301" points="6131 697" /> <Output id="680" stoichiometry="2" points="6116 734" /> <Output id="685" points="6128 660" /> </Outputs> <Catalysts> <Catalyst id="663" points="6240 454, 6157 578" /> </Catalysts> <Properties> <displayName>MEOS oxidizes ethanol to acetaldehyde</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1116" reactomeId="211923" points="2665 1318, 2706 1318, 2761 1318" position="2706 1318" lineWidth="1.0"> <Inputs> <Input id="1117" points="2607 1318" /> <Input id="1128" points="2665 1287" /> <Input id="1130" points="2614 1280" /> <Input id="1132" points="2627 1248" /> </Inputs> <Outputs> <Output id="1118" points="2783 1276" /> <Output id="1119" points="2818 1318" /> <Output id="1126" points="2851 1244" /> </Outputs> <Catalysts> <Catalyst id="1120" points="2705 1354" /> </Catalysts> <Properties> <displayName>CYP26C1 4-hydroxylates 9cRA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1161" reactomeId="194017" points="9360 1168, 9394 1167, 9424 1168" position="9394 1167" lineWidth="1.0"> <Inputs> <Input id="1162" points="9328 1168" /> <Input id="1172" stoichiometry="2" points="9344 1228" /> <Input id="1170" stoichiometry="2" points="9333 1144" /> <Input id="1168" points="9323 1198" /> </Inputs> <Outputs> <Output id="1163" points="9479 1168" /> <Output id="1166" stoichiometry="2" points="9498 1233" /> <Output id="1164" points="9491 1198" /> </Outputs> <Catalysts> <Catalyst id="1173" points="9394 1124" /> </Catalysts> <Properties> <displayName>CYP11B2 oxidises 11DCORST to CORST</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1196" reactomeId="193965" points="9676 1318, 9676 1363, 9677 1398" position="9676 1363" lineWidth="1.0"> <Inputs> <Input id="1180" points="9675 1289" /> <Input id="1204" stoichiometry="2" points="9628 1335" /> <Input id="1202" stoichiometry="2" points="9580 1310" /> <Input id="1200" points="9619 1291" /> </Inputs> <Outputs> <Output id="2813" stoichiometry="2" points="9611 1440" /> <Output id="1197" points="9677 1446" /> <Output id="1206" stoichiometry="2" points="9630 1398" /> </Outputs> <Catalysts> <Catalyst id="1173" points="9428 1106, 9748 1080, 9749 1361" /> </Catalysts> <Properties> <displayName>CYP11B2 oxidises 18HCORST to ALDO</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1211" reactomeId="193995" points="9639 1178, 9641 1198, 9640 1202, 9641 1228" position="9640 1202" lineWidth="1.0"> <Inputs> <Input id="1163" points="9541 1170" /> <Input id="1216" stoichiometry="2" points="9593 1155" /> <Input id="1214" stoichiometry="2" points="9671 1150" /> <Input id="1218" points="9640 1151" /> </Inputs> <Outputs> <Output id="1180" points="9662 1252" /> <Output id="1166" stoichiometry="2" points="9549 1245" /> <Output id="1164" points="9540 1211" /> </Outputs> <Catalysts> <Catalyst id="1173" points="9428 1108, 9725 1106, 9726 1200" /> </Catalysts> <Properties> <displayName>CYP11B2 18-hydroxylates CORST to 18HCORST</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1233" reactomeId="215526" points="933 498, 973 497, 1014 497" position="973 497" lineWidth="1.0"> <Inputs> <Input id="1234" points="862 498" /> <Input id="1248" points="917 522" /> <Input id="1250" points="879 524" /> <Input id="1252" points="894 475" /> </Inputs> <Outputs> <Output id="1235" points="1048 522" /> <Output id="1236" points="1053 497" /> <Output id="1246" points="1048 477" /> </Outputs> <Catalysts> <Catalyst id="1237" points="973 455" /> </Catalysts> <Properties> <displayName>CYP4F3 20-hydroxylates LTB4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1264" reactomeId="5602295" points="258 383, 322 383, 322 383" position="322 383" lineWidth="1.0"> <Inputs> <Input id="1265" points="201 384" /> <Input id="1275" points="209 331" /> <Input id="1277" points="221 399" /> <Input id="1279" points="215 360" /> </Inputs> <Outputs> <Output id="1266" points="388 319" /> <Output id="1267" points="366 381" /> <Output id="1281" points="376 356" /> </Outputs> <Catalysts> <Catalyst id="1268" points="322 415" /> </Catalysts> <Properties> <displayName>CYP4F22 20-hydroxylates TrXA3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1282" reactomeId="5692237" points="7578 1520, 7618 1520, 7664 1520" position="7618 1520" lineWidth="1.0"> <Inputs> <Input id="1283" points="7547 1520" /> <Input id="1291" points="7549 1539" /> </Inputs> <Outputs> <Output id="1284" points="7722 1520" /> <Output id="1287" points="7753 1552" /> <Output id="1289" points="7700 1546" /> </Outputs> <Catalysts> <Catalyst id="1285" points="7618 1494" /> </Catalysts> <Properties> <displayName>ADH5 oxidises S-HMGSH to S-FGSH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1301" reactomeId="5692283" points="7153 1527, 7193 1527, 7249 1527" position="7193 1527" lineWidth="1.0"> <Inputs> <Input id="1302" points="7098 1527" /> <Input id="1303" points="7124 1543" /> <Input id="1311" points="7122 1509" /> </Inputs> <Outputs> <Output id="1304" points="7293 1527" /> <Output id="1307" points="7270 1556" /> <Output id="1309" points="7302 1549" /> </Outputs> <Catalysts> <Catalyst id="1305" points="7193 1499" /> </Catalysts> <Inhibitors> <Inhibitor id="2594" points="6795 1687, 7105 1687" /> </Inhibitors> <Activators> <Activator id="2522" points="6902 1734, 7192 1728" /> </Activators> <Properties> <displayName>ALD3A1 oxidises 4HPCP to CXPA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1312" reactomeId="5693691" points="4131 1187, 4183 1187, 4230 1187" position="4183 1187" lineWidth="1.0"> <Inputs> <Input id="1313" points="4104 1187" /> <Input id="1314" points="4103 1210" /> </Inputs> <Outputs> <Output id="1315" points="4302 1201" /> <Output id="1316" points="4304 1158" /> <Output id="1319" points="4266 1221" /> </Outputs> <Catalysts> <Catalyst id="1317" points="4183 1164" /> </Catalysts> <Properties> <displayName>CES1 trimer.CES2 hydrolyse COCN to BEG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1320" reactomeId="5694077" points="4504 1297, 4550 1298, 4571 1298" position="4550 1298" lineWidth="1.0"> <Inputs> <Input id="1321" points="4476 1297" /> <Input id="1322" points="4469 1275" /> </Inputs> <Outputs> <Output id="1323" /> </Outputs> <Catalysts> <Catalyst id="1324" points="4550 1350" /> </Catalysts> <Properties> <displayName>EPHX1 hydrates BaP4,5O to BaP4,5-DHD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1720" reactomeId="5696131" points="94 76, 133 75, 177 75" position="133 75" lineWidth="1.0"> <Inputs> <Input id="1722" points="74 91" /> <Input id="1723" points="63 76" /> <Input id="1798" points="77 60" /> </Inputs> <Outputs> <Output id="1727" points="232 75" /> <Output id="1788" points="185 44" /> <Output id="1790" points="219 50" /> <Output id="1794" points="202 91" /> </Outputs> <Catalysts> <Catalyst id="1728" points="133 127" /> </Catalysts> <Properties> <displayName>AOC1 deaminates Hist</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1729" reactomeId="5696146" points="422 76, 457 76, 497 76" position="457 76" lineWidth="1.0"> <Inputs> <Input id="1730" points="395 76" /> <Input id="1731" points="414 64" /> <Input id="1800" points="412 94" /> </Inputs> <Outputs> <Output id="1732" points="551 76" /> <Output id="1792" points="540 100" /> <Output id="1796" points="518 55" /> <Output id="1802" points="512 100" /> </Outputs> <Catalysts> <Catalyst id="1733" points="457 134" /> </Catalysts> <Properties> <displayName>AOC2 deaminates TYR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1734" reactomeId="5696183" points="766 82, 820 82, 859 82" position="820 82" lineWidth="1.0"> <Inputs> <Input id="1721" points="748 104" /> <Input id="1735" points="750 63" /> <Input id="1736" points="734 82" /> </Inputs> <Outputs> <Output id="1724" points="893 104" /> <Output id="1725" points="908 42" /> <Output id="1726" points="875 41" /> <Output id="1737" points="918 82" /> </Outputs> <Catalysts> <Catalyst id="1738" points="820 128" /> </Catalysts> <Properties> <displayName>AOC3 deaminates BZAM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1851" reactomeId="5696091" points="8739 1628, 8772 1628, 8800 1628" position="8772 1628" lineWidth="1.0"> <Inputs> <Input id="558" points="8679 1569" /> <Input id="578" points="8660 1611" /> <Input id="561" points="8701 1651" /> </Inputs> <Outputs> <Output id="569" points="8897 1612" /> <Output id="560" points="8862 1588" /> <Output id="582" points="8835 1653" /> </Outputs> <Catalysts> <Catalyst id="1853" points="8772 1669" /> </Catalysts> <Properties> <displayName>ALDH1B1 tetramer oxidises CH3CHO to CH3COOH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1861" reactomeId="5689000" points="4883 1295, 4922 1295, 4957 1295" position="4922 1295" lineWidth="1.0"> <Inputs> <Input id="1862" points="4873 1279" /> <Input id="1863" points="4858 1295" /> </Inputs> <Outputs> <Output id="1864" points="4978 1278" /> <Output id="1865" points="5001 1295" /> </Outputs> <Catalysts> <Catalyst id="1866" points="4921 1349" /> </Catalysts> <Properties> <displayName>AADAC deacetylates PHEN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1873" reactomeId="6784959" points="8759 925, 8789 925, 8812 925" position="8789 925" lineWidth="1.0"> <Inputs> <Input id="1874" points="8736 901" /> <Input id="1875" points="8732 925" /> </Inputs> <Outputs> <Output id="1876" points="8853 925" /> <Output id="1879" points="8822 901" /> </Outputs> <Catalysts> <Catalyst id="1877" points="8787 951" /> </Catalysts> <Properties> <displayName>BPHL hydrolyses VACV to ACV</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1880" reactomeId="6786190" points="5131 249, 5168 249, 5210 249" position="5168 249" lineWidth="1.0"> <Inputs> <Input id="1881" points="5090 249" /> <Input id="1882" points="5111 267" /> </Inputs> <Outputs> <Output id="2689" points="5247 248" /> <Output id="1883" points="5230 276" /> </Outputs> <Catalysts> <Catalyst id="1885" points="5168 215" /> </Catalysts> <Properties> <displayName>CMBL hydrolyses OM to OLMS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2388" reactomeId="6786239" points="5292 1427, 5338 1427, 5381 1427" position="5338 1427" lineWidth="1.0"> <Inputs> <Input id="2389" points="5250 1381" /> <Input id="2394" points="5233 1443" /> <Input id="2396" points="5256 1417" /> <Input id="2398" points="5268 1448" /> </Inputs> <Outputs> <Output id="2390" points="5434 1383" /> <Output id="2391" points="5422 1418" /> <Output id="2400" points="5412 1449" /> </Outputs> <Catalysts> <Catalyst id="2392" points="5339 1381" /> </Catalysts> <Properties> <displayName>CYP4V2 omega-hydroxylates DHA to HDoHE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2401" reactomeId="76494" points="7587 377, 7625 377, 7664 377" position="7625 377" lineWidth="1.0"> <Inputs> <Input id="2561" stoichiometry="2" points="7547 418" /> <Input id="2406" points="7547 356" /> </Inputs> <Outputs> <Output id="2562" stoichiometry="2" points="7711 421" /> <Output id="2408" points="7708 356" /> <Output id="2833" points="7721 384" /> </Outputs> <Catalysts> <Catalyst id="2404" points="7626 421" /> </Catalysts> <Properties> <displayName>POR reduces CYP450:Fe3+ to CYP450:Fe2+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2448" reactomeId="8936442" points="9114 914, 9159 914, 9238 914" position="9159 914" lineWidth="1.0"> <Inputs> <Input id="2449" points="9055 914" /> <Input id="2454" points="9094 928" /> <Input id="2458" points="9089 893" /> </Inputs> <Outputs> <Output id="2450" points="9256 927" /> <Output id="2451" points="9294 914" /> <Output id="2456" points="9270 889" /> </Outputs> <Catalysts> <Catalyst id="2452" points="9157 953" /> </Catalysts> <Properties> <displayName>MARC1,MARC2 reduce N-hydroxylated compounds</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2461" reactomeId="8936519" points="5575 272, 5625 272, 5680 272" position="5625 272" lineWidth="1.0"> <Inputs> <Input id="2462" points="5534 272" /> <Input id="2463" points="5538 236" /> </Inputs> <Outputs> <Output id="2464" points="5754 272" /> <Output id="2465" points="5728 236" /> </Outputs> <Catalysts> <Catalyst id="2466" points="5625 230" /> </Catalysts> <Inhibitors> <Inhibitor id="2541" points="5668 312" /> <Inhibitor id="2542" points="5604 314" /> </Inhibitors> <Properties> <displayName>NQO2:FAD dimer reduces quinones to hydroquinones</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2526" reactomeId="8937419" points="5752 1514, 5779 1515, 5823 1515" position="5779 1515" lineWidth="1.0"> <Inputs> <Input id="2695" points="5723 1513" /> <Input id="2532" points="5738 1531" /> </Inputs> <Outputs> <Output id="2528" points="5861 1515" /> <Output id="2534" points="5840 1532" /> </Outputs> <Catalysts> <Catalyst id="2529" points="5779 1488" /> </Catalysts> <Properties> <displayName>CBR3 reduces DOX to DOXOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2535" reactomeId="8937442" points="1192 252, 1229 252, 1275 252" position="1229 252" lineWidth="1.0"> <Inputs> <Input id="2543" points="1180 269" /> <Input id="2544" points="1141 252" /> </Inputs> <Outputs> <Output id="2545" points="1288 269" /> <Output id="2546" points="1333 252" /> </Outputs> <Catalysts> <Catalyst id="2540" points="1228 225" /> </Catalysts> <Properties> <displayName>CES3 hydrolyses CHEST to CHOL and LCFA(-)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2548" interactionType="Activate" points="6696 1736, 6787 1736" position="6741 1736" lineWidth="2.0"> <Inputs> <Input id="2547" /> </Inputs> <Outputs> <Output id="2522" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2559" reactomeId="141186" points="8425 832, 8463 833, 8502 833" position="8463 833" lineWidth="1.0"> <Inputs> <Input id="460" points="8432 782" /> <Input id="2560" points="8400 808" /> <Input id="459" points="8376 832" /> </Inputs> <Outputs> <Output id="462" points="8567 799" /> <Output id="2647" points="8522 777" /> <Output id="458" points="8550 846" /> </Outputs> <Catalysts> <Catalyst id="447" points="8539 966" /> </Catalysts> <Properties> <displayName>MAOA:FAD oxidatively deaminates of 5HT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2606" reactomeId="76456" points="3023 653, 3086 653, 3151 652" position="3086 653" lineWidth="1.0"> <Inputs> <Input id="2607" points="2942 609" /> <Input id="255" points="2918 656" /> <Input id="239" points="2919 695" /> <Input id="227" points="2913 741" /> </Inputs> <Outputs> <Output id="2609" points="3228 609" /> <Output id="281" points="3236 739" /> <Output id="270" points="3231 686" /> <Output id="2611" points="3240 644" /> </Outputs> <Catalysts> <Catalyst id="706" points="3086 693" /> </Catalysts> <Properties> <displayName>O-atom dealkylation of dextromethorphan</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2616" reactomeId="9677929" points="8258 1441, 8278 1440, 8304 1440" position="8278 1440" lineWidth="1.0"> <Inputs> <Input id="2617" points="8216 1519" /> <Input id="448" points="8259 1375" /> </Inputs> <Outputs> <Output id="2618" /> </Outputs> <Properties> <displayName>MAOB inhibitors bind MAOB:FAD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2621" reactomeId="9677917" points="8465 945, 8416 970, 8356 1001" position="8416 970" lineWidth="1.0"> <Inputs> <Input id="447" points="8519 966" /> <Input id="2622" points="8403 922" /> </Inputs> <Outputs> <Output id="2624" /> </Outputs> <Properties> <displayName>MAOA inhibitors bind MAOA:FAD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="2623" points="8323 912, 7950 976, 7963 1271, 8200 1519" position="7956 1123" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="2622" /> </Inputs> <Outputs> <Output id="2617" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="2635" reactomeId="9678766" points="7490 1363, 7551 1364, 7593 1363" position="7551 1364" lineWidth="1.0"> <Inputs> <Input id="2636" points="7451 1363" /> <Input id="2637" points="7491 1398" /> </Inputs> <Outputs> <Output id="2638" /> </Outputs> <Properties> <displayName>CYP3A4 binds CYP3A4 inhibitors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2643" reactomeId="9680865" points="7195 1365, 7223 1365, 7259 1365" position="7223 1365" lineWidth="1.0"> <Inputs> <Input id="2644" points="7196 1396" /> <Input id="2645" points="7167 1365" /> </Inputs> <Outputs> <Output id="2646" /> </Outputs> <Properties> <displayName>CYP3A4, CYP2B6 bind ritonavir</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2834" reactomeId="9971246" points="1327 493, 1357 493, 1388 493" position="1357 493" lineWidth="1.0"> <Inputs> <Input id="2835" points="1279 495" /> <Input id="2845" points="1280 524" /> <Input id="2847" points="1241 470" /> </Inputs> <Outputs> <Output id="2836" points="1455 494" /> <Output id="2837" points="1539 546" /> <Output id="2843" points="1401 516" /> <Output id="2849" points="1489 550" /> </Outputs> <Catalysts> <Catalyst id="2838" points="1355 454" /> </Catalysts> <Properties> <displayName>Unknown CYP 450 omega-hydroxylates C10 fatty acid</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2853" reactomeId="9971258" points="5425 1721, 5454 1720, 5483 1719" position="5454 1720" lineWidth="1.0"> <Inputs> <Input id="2854" points="5406 1726" /> <Input id="2865" points="5379 1699" /> </Inputs> <Outputs> <Output id="2855" points="5556 1719" /> <Output id="2858" points="5530 1687" /> <Output id="2863" points="5550 1769" /> </Outputs> <Catalysts> <Catalyst id="2856" points="5455 1756" /> </Catalysts> <Properties> <displayName>ADH7 dehydrogenates 10-OH-DECA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2869" reactomeId="9971429" points="5703 1719, 5739 1718, 5773 1719" position="5739 1718" lineWidth="1.0"> <Inputs> <Input id="2855" points="5646 1719" /> <Input id="2870" points="5688 1698" /> <Input id="2876" points="5672 1740" /> </Inputs> <Outputs> <Output id="2871" points="5831 1720" /> <Output id="2874" points="5812 1749" /> <Output id="2878" stoichiometry="2" points="5827 1687" /> </Outputs> <Catalysts> <Catalyst id="2872" points="5739 1774" /> </Catalysts> <Properties> <displayName>Unknown ALDH oxidizes 10-oxo-DECA</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Phase I - Functionalization of compounds, Defective CYP11A1 causes AICSR, Defective CYP11B1 causes AH4, Defective CYP11B2 causes CMO-1 deficiency, Defective CYP19A1 causes AEXS, Defective CYP1B1 causes Glaucoma, Defective CYP21A2 causes AH3, Defective CYP24A1 causes HCAI, Defective CYP26B1 causes RHFCA, Defective CYP26C1 causes FFDD4, Defective CYP2U1 causes SPG56, Defective CYP4F22 causes ARCI5, Defective CYP7B1 causes SPG5A and CBAS3, Defective FMO3 causes TMAU, Defective MAOA causes BRUNS, and Defective TBXAS1 causes GHDD (500339)
