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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Toll-Like Receptors Cascades

Class:IdPathwayDiagram:500232
_displayNameDiagram of Toll-Like Receptors Cascades
_timestamp2024-05-10 16:21:06
created[InstanceEdit:500231] Jupe, S, 2010-02-01
height928
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:1843854] Shamovsky, V, 2011-10-27
[InstanceEdit:1986611] Shamovsky, V, 2011-11-11
[InstanceEdit:2011829] Shamovsky, V, 2011-11-22
[InstanceEdit:2011832] Shamovsky, V, 2011-11-22
[InstanceEdit:2129010] Shamovsky, V, 2012-02-19
[InstanceEdit:2134527] Shamovsky, V, 2012-02-23
[InstanceEdit:2201367] Shamovsky, V, 2012-04-19
[InstanceEdit:2201369] Shamovsky, V, 2012-04-19
[InstanceEdit:2206279] Shamovsky, V, 2012-04-26
[InstanceEdit:2213019] Shamovsky, V, 2012-04-27
[InstanceEdit:2423838] Shamovsky, V, 2012-07-20
[InstanceEdit:2559472] Shamovsky, V, 2012-11-02
[InstanceEdit:2559579] Shamovsky, V, 2012-11-02
[InstanceEdit:2585259] Shamovsky, V, 2012-11-15
[InstanceEdit:3288225] Shamovsky, V, 2013-04-15
[InstanceEdit:5602772] Shamovsky, Veronica, 2014-06-24
[InstanceEdit:5615681] Shamovsky, V, 2014-07-29
[InstanceEdit:5675071] Shamovsky, Veronica, 2015-02-15
[InstanceEdit:5675108] Shamovsky, Veronica, 2015-02-15
[InstanceEdit:6789538] D'Eustachio, Peter, 2015-07-31
[InstanceEdit:6790600] Shamovsky, Veronica, 2015-08-14
[InstanceEdit:6809987] Shamovsky, Veronica, 2015-11-13
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8877508] Orlic-Milacic, Marija, 2016-06-22
[InstanceEdit:8877510] Orlic-Milacic, Marija, 2016-06-22
[InstanceEdit:9014708] Shamovsky, Veronica, 2017-08-02
[InstanceEdit:9028372] Shamovsky, Veronica, 2017-11-07
[InstanceEdit:9028374] Shamovsky, Veronica, 2017-11-07
[InstanceEdit:9029371] Jupe, Steve, 2017-11-16
[InstanceEdit:9032292] Shamovsky, Veronica, 2017-12-08
[InstanceEdit:9034694] Shamovsky, Veronica, 2018-01-10
[InstanceEdit:9628996] Shamovsky, Veronica, 2018-11-15
[InstanceEdit:9638024] D'Eustachio, Peter, 2019-02-22
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9687129] Shamovsky, Veronica, 2020-05-06
[InstanceEdit:9691210] Jassal, Bijay, 2020-06-09
[InstanceEdit:9696615] Jassal, Bijay, 2020-07-23
[InstanceEdit:9699210] Jassal, Bijay, 2020-09-14
[InstanceEdit:9708728] Shamovsky, Veronica, 2020-12-01
[InstanceEdit:9708850] Shamovsky, Veronica, 2020-12-01
[InstanceEdit:9724893] Stephan, Ralf, 2021-03-26
[InstanceEdit:9767735] Shamovsky, Veronica, 2022-03-01
[InstanceEdit:9767889] Matthews, Lisa, 2022-03-02
[InstanceEdit:9768028] Shamovsky, Veronica, 2022-03-03
[InstanceEdit:9861106] Shamovsky, Veronica, 2024-02-13
[InstanceEdit:9909357] Shamovsky, Veronica, 2024-05-10
representedPathway[Pathway:168898] Toll-like Receptor Cascades [Homo sapiens]
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textPosition="186 323"> <Properties> <displayName>TLR5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="492" reactomeId="167919" position="140 338" bounds="110 327 60 22" textPosition="113 327" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" lineWidth="1.0" isForDisease="true"> <Properties> <displayName>Flagellin</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="493" reactomeId="188027" position="197 436" bounds="139 418 116 36" textPosition="141 418" bgColor="204 255 255" fgColor="0 0 0" lineColor="204 0 0" hideComponents="true"> <Properties> <displayName>TLR5 homodimer:bacterial flagellin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1693" reactomeId="975871" position="195 710" bounds="136 672 119 77" textPosition="139 674" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>MyD88 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textPosition="1741 277" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Integrin alphaMbeta2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2754" reactomeId="2559438" position="1945 303" bounds="1897 292 96 22" textPosition="1899 292" bgColor="204 255 255" fgColor="0 0 0" lineColor="204 0 0" lineWidth="1.0" hideComponents="true"> <Properties> <displayName>LPS:CD14:CR3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3563" reactomeId="2559462" position="1255 816" bounds="1197 798 117 36" textPosition="1198 798" bgColor="204 255 255" fgColor="0 0 0" lineColor="204 0 0" lineWidth="1.0" hideComponents="true"> <Properties> <displayName>TLR1:TLR2 ligand:CD14</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="3616" reactomeId="166033" position="211 783" bounds="147 765 129 36" textPosition="160 765"> <Properties> <displayName>GPIN-CD14(20-345)</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.12403100775193798" relativeY="0.0" label="PI" trackId="0" reactomeId="166032" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="3847" reactomeId="2559461" position="884 820" bounds="836 802 96 36" textPosition="836 802" bgColor="204 255 255" fgColor="0 0 0" lineColor="204 0 0" lineWidth="1.0" hideComponents="true"> <Properties> <displayName>TLR6/2 ligand:CD14:CD36</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="3982" reactomeId="51645" position="560 815" bounds="510 804 100 22" textPosition="510 804"> <Properties> <displayName>4xPalmC-CD36</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1297709923664122" relativeY="0.0" label="Pa" description="Cyc" trackId="0" reactomeId="2187205" /> <org.gk.render.RenderableFeature relativeX="0.26717557251908397" relativeY="0.0" label="Pa" description="Cyc" trackId="0" reactomeId="2187204" /> <org.gk.render.RenderableFeature relativeX="0.40458015267175573" relativeY="0.0" label="Pa" description="Cyc" trackId="0" reactomeId="2187208" /> <org.gk.render.RenderableFeature relativeX="0.5419847328244275" relativeY="0.0" label="Pa" description="Cyc" trackId="0" reactomeId="2187207" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="3983" reactomeId="391108" position="1409 742" bounds="1353 724 113 36" textPosition="1357 724"> <Properties> <displayName>SFTPA oligomer, SFTPD oligomer</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="3984" reactomeId="391108" position="764 135" bounds="708 117 113 36" textPosition="712 117" /> <org.gk.render.RenderableProtein id="3986" reactomeId="6806211" position="143 136" bounds="129 125 28 22" textPosition="130 125"> <Properties> <displayName>BPI</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="3987" reactomeId="5686938" position="1829 891" bounds="1765 862 129 58" textPosition="1769 862"> <Properties> <displayName>Regulation of TLR by endogenous ligand</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="3988" reactomeId="8877173" position="1527 396" bounds="1503 385 49 22" textPosition="1504 385"> <Properties> <displayName>PTPN4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="3990" reactomeId="168164" position="1522 450" bounds="1451 413 142 74" textPosition="1454 428"> <Properties> <displayName>Toll Like Receptor 3 (TLR3) Cascade</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableEntitySet id="4030" reactomeId="9628992" position="614 878" bounds="558 860 112 36" textPosition="558 860" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>TLR6:TLR2 recognized ligand</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="4031" reactomeId="9684904" position="578 538" bounds="516 520 125 36" textPosition="518 527" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>TLR7, TLR8 ligands</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="4286" reactomeId="1679575" position="478 442" bounds="441 424 74 36" textPosition="440 424" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>C-ter TLR7 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="4381" reactomeId="1679576" position="572 442" bounds="534 431 77 22" textPosition="534 431" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TLR8 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="4382" reactomeId="9691207" position="684 444" bounds="627 426 115 36" textPosition="627 426" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TLR8 dimer:TLR7,TLR8 ligands</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemicalDrug id="4483" reactomeId="9678628" position="359 344" bounds="335 328 49 32" textPosition="342 333" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true" /> <org.gk.render.RenderableComplex id="4484" reactomeId="9678617" position="359 452" bounds="308 435 103 35" textPosition="321 434" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>C-ter TLR7 dimer:HCQ</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="4716" reactomeId="9678655" position="1153 441" bounds="1095 423 116 36" textPosition="1095 423" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>C-ter TLR9 dimer:HCQ</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemicalDrug id="4717" reactomeId="9678628" position="1000 380" bounds="976 364 49 32" textPosition="983 369" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>HCQ</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableChemicalDrug id="4759" reactomeId="9724672" position="279 368" bounds="241 353 76 31" textPosition="244 357" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>imiquimod</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableComplex id="4760" reactomeId="9724662" position="331 538" bounds="272 520 118 36" textPosition="273 520" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>C-ter TLR7 dimer:imiquimod</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="4761" reactomeId="984806" position="1695 361" bounds="1672 350 47 23" textPosition="1672 350"> <Properties> <displayName>PLCG2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="4774" reactomeId="9860276" position="742 659" bounds="686 630 113 59" textPosition="686 630"> <Properties> <displayName>SLC15A4:TASL-dependent IRF5 activation</displayName> </Properties> </org.gk.render.ProcessNode> </Nodes> <Edges> <org.gk.render.RenderableReaction id="222" reactomeId="168947" points="177 539, 176 560, 176 586" position="176 560" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="224" points="150 530" /> <Input id="223" stoichiometry="2" points="200 504" /> </Inputs> <Outputs> <Output id="225" /> </Outputs> <Properties> <displayName>Ligand binds to TLR10</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="258" reactomeId="167983" points="445 512, 445 512, 362 604" position="445 512" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="4031" points="510 525" /> <Input id="4286" points="469 463" /> </Inputs> <Outputs> <Output id="261" /> </Outputs> <Inhibitors> <Inhibitor id="4484" points="384 473" /> </Inhibitors> <Properties> <displayName>C-ter TLR7 dimer binds TLR7, TLR8 ligands</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="266" reactomeId="187895" points="1036 556, 1036 557, 1169 637" position="1036 557" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="1954" points="999 536" /> <Input id="2144" points="1036 462" /> </Inputs> <Outputs> <Output id="1956" /> </Outputs> <Inhibitors> <Inhibitor id="4716" points="1134 462" /> </Inhibitors> <Activators> <Activator id="270" points="1030 659" /> </Activators> <Properties> <displayName>Engulfed CpG DNA binds to endosomal C-ter TLR9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="271" reactomeId="188002" points="1403 668, 1403 667, 1482 667" position="1403 667" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="272" points="1384 686" /> <Input id="1956" points="1277 665" /> </Inputs> <Outputs> <Output id="273" /> </Outputs> <Activators> <Activator id="274" points="1409 614" /> </Activators> <Properties> <displayName>Rab5-mediated recruitment of class III PI3K to TLR9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="278" reactomeId="166015" points="122 176, 144 176, 171 176" position="144 176" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="280" points="102 151" /> <Input id="1807" points="99 195" /> </Inputs> <Outputs> <Output id="281" /> </Outputs> <Inhibitors> <Inhibitor id="3986" points="143 150" /> </Inhibitors> <Properties> <displayName>Association of LBP with LPS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="291" reactomeId="166041" points="704 239, 765 239, 1503 244, 1564 275" position="765 239" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="292" stoichiometry="2" points="655 276" /> <Input id="2583" points="658 206" /> </Inputs> <Outputs> <Output id="294" /> </Outputs> <Inhibitors> <Inhibitor id="296" points="762 273, 755 253" /> <Inhibitor id="3984" points="764 159" /> </Inhibitors> <Properties> <displayName>Transfer of LPS onto TLR4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="480" reactomeId="168951" points="1384 791, 1410 790, 1480 804" position="1410 790" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="481" points="1373 808" /> <Input id="3563" points="1283 795, 1297 789" /> </Inputs> <Outputs> <Output id="483" /> </Outputs> <Inhibitors> <Inhibitor id="3983" points="1409 766" /> </Inhibitors> <Properties> <displayName>TLR1:TLR2 is recruited to ligand:CD14</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="485" reactomeId="168950" points="1029 859, 1029 859, 1029 859, 1566 858, 1639 838" position="1029 859" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="487" points="990 832" /> <Input id="3847" points="935 832" /> </Inputs> <Outputs> <Output id="488" /> </Outputs> <Properties> <displayName>TLR6:TLR2 is recruited to ligand:CD14:CD36</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="490" reactomeId="188025" points="173 372, 172 393, 186 415" position="172 393" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="491" stoichiometry="2" points="195 348" /> <Input id="492" points="150 352" /> </Inputs> <Outputs> <Output id="493" /> </Outputs> <Properties> <displayName>Flagellin binds to TLR5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="738" reactomeId="166038" points="265 216, 303 216, 337 216" position="303 216" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="281" points="241 192" /> <Input id="284" points="236 279" /> </Inputs> <Outputs> <Output id="279" points="363 192" /> <Output id="285" points="432 274" /> </Outputs> <Properties> <displayName>GPI-bound CD14 binds LPS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="739" reactomeId="169719" points="263 141, 297 142, 330 141" position="297 142" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="281" points="241 164" /> <Input id="287" points="214 106" /> </Inputs> <Outputs> <Output id="279" points="360 164" /> <Output id="288" points="396 103" /> </Outputs> <Properties> <displayName>Secreted CD14 binds LPS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1803" interactionType="Activate" points="179 628, 187 669" position="183 648" lineWidth="1.5" lineColor="0 0 0"> <Inputs> <Input id="225" /> </Inputs> <Outputs> <Output id="1693" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1805" interactionType="Activate" points="213 457, 243 486, 243 645, 223 669" position="243 565" lineWidth="1.5" lineColor="0 0 0"> <Inputs> <Input id="493" /> </Inputs> <Outputs> <Output id="1693" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1951" interactionType="Activate" points="413 624, 490 624, 505 628" position="490 624" lineWidth="1.5" lineColor="0 0 0"> <Inputs> <Input id="261" /> </Inputs> <Outputs> <Output id="1694" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1958" interactionType="Activate" points="1143 679, 907 736, 660 734, 617 699" position="783 735" lineWidth="1.5" lineColor="0 0 0"> <Inputs> <Input id="1956" /> </Inputs> <Outputs> <Output id="1694" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2031" interactionType="Activate" points="886 371, 1002 424" position="944 397" lineWidth="2.0"> <Inputs> <Input id="2027" /> </Inputs> <Outputs> <Output id="2144" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2033" interactionType="Activate" points="886 345, 1383 358, 1466 410" position="1383 358" lineWidth="2.0"> <Inputs> <Input id="2027" /> </Inputs> <Outputs> <Output id="3990" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2124" interactionType="Activate" points="841 379, 871 421" position="856 400" lineWidth="2.0"> <Inputs> <Input id="2027" /> </Inputs> <Outputs> <Output id="2112" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2302" reactomeId="1679589" points="1289 502, 1289 502, 1332 480" position="1289 502" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="2303" stoichiometry="2" points="1261 458" /> <Input id="1954" points="1016 511, 1237 513" /> </Inputs> <Outputs> <Output id="2353" /> </Outputs> <Properties> <displayName>Engulfed CpG DNA binds to endosomal full-length TLR9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2306" interactionType="Activate" points="886 349, 1176 376, 1242 430" position="1176 376" lineWidth="2.0"> <Inputs> <Input id="2027" /> </Inputs> <Outputs> <Output id="2303" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2358" reactomeId="1679098" points="884 549, 884 607, 884 647" position="884 607" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="2112" points="884 464" /> <Input id="1954" points="917 532" /> </Inputs> <Outputs> <Output id="2359" /> </Outputs> <Activators> <Activator id="270" points="1005 659" /> </Activators> <Properties> <displayName>Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="2584" points="494 274, 626 206" position="560 240" lineWidth="1.5" lineColor="0 0 0"> <Inputs> <Input id="285" /> </Inputs> <Outputs> <Output id="2583" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2585" points="441 103, 619 172" position="530 137" lineWidth="1.5" lineColor="0 0 0"> <Inputs> <Input id="288" /> </Inputs> <Outputs> <Output id="2583" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2586" reactomeId="2201293" points="1597 317, 1597 361, 1842 430" position="1597 361" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="294" /> </Inputs> <Outputs> <Output id="2587" /> </Outputs> <Activators> <Activator id="2602" points="1477 308" /> <Activator id="4761" points="1669 361" /> </Activators> <Properties> <displayName>Endocytosis of TLR4:LY96:LPS:CD14</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2650" interactionType="Activate" points="1763 671, 1786 671" position="1774 671" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="2648" /> </Inputs> <Outputs> <Output id="1696" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2730" reactomeId="2201341" points="1371 314, 1542 362, 1711 424" position="1542 362" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="2625" /> </Inputs> <Outputs> <Output id="2626" /> </Outputs> <Inhibitors> <Inhibitor id="3988" points="1531 382" /> </Inhibitors> <Properties> <displayName>Endocytosis of TRAM (TICAM2)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2741" reactomeId="166168" points="1788 520, 1789 551, 1716 652" position="1789 551" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="2587" points="1878 469" /> <Input id="2626" stoichiometry="2" points="1765 466" /> </Inputs> <Outputs> <Output id="2648" /> </Outputs> <Properties> <displayName>TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2752" reactomeId="2559439" points="1864 267, 1894 267, 1929 289" position="1894 267" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="2583" points="686 189, 1718 199" /> <Input id="2753" stoichiometry="2" points="1835 274" /> </Inputs> <Outputs> <Output id="2754" stoichiometry="2" /> </Outputs> <Properties> <displayName>CD14:LPS binds CR3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3614" reactomeId="2559468" points="1155 776, 1185 777, 1222 795" position="1185 777" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="482" points="1136 791" /> <Input id="3616" points="279 774, 456 749" /> </Inputs> <Outputs> <Output id="3563" /> </Outputs> <Properties> <displayName>TLR1/2 ligand binds to CD14</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3981" reactomeId="2559464" points="729 840, 766 841, 833 828" position="766 841" lineWidth="1.0" lineColor="0 0 0" reactionType="Association"> <Inputs> <Input id="3982" points="613 822" /> <Input id="4030" points="668 854" /> <Input id="284" points="162 300, 30 301, 26 842" /> </Inputs> <Outputs> <Output id="3847" /> </Outputs> <Properties> <displayName>TLR6/2 ligand associates with CD14 and CD36 within lipid rafts</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="4024" interactionType="Activate" points="1665 308, 2006 375, 2004 676, 1956 750" position="2005 525" lineWidth="2.0"> <Inputs> <Input id="294" /> </Inputs> <Outputs> <Output id="1695" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="4027" interactionType="Activate" points="1552 796, 1558 788, 1867 788" position="1558 788" lineWidth="2.0"> <Inputs> <Input id="483" /> </Inputs> <Outputs> <Output id="1695" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="4029" interactionType="Activate" points="1762 814, 1867 798" position="1814 806" lineWidth="2.0"> <Inputs> <Input id="488" /> </Inputs> <Outputs> <Output id="1695" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="4380" reactomeId="9691204" points="589 470, 589 472, 624 460" position="589 472" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4031" points="580 514" /> <Input id="4381" points="578 456" /> </Inputs> <Outputs> <Output id="4382" /> </Outputs> <Properties> <displayName>TLR8 dimer binds TLR7, TLR8 ligands</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="4383" interactionType="Activate" points="758 361, 518 431" position="638 396" lineWidth="2.0"> <Inputs> <Input id="2027" /> </Inputs> <Outputs> <Output id="4286" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="4384" interactionType="Activate" points="758 367, 599 428" position="678 397" lineWidth="2.0"> <Inputs> <Input id="2027" /> </Inputs> <Outputs> <Output id="4381" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="4385" interactionType="Activate" points="577 562, 578 628" position="577 595" lineWidth="2.0"> <Inputs> <Input id="4031" /> </Inputs> <Outputs> <Output id="1694" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="4482" reactomeId="9679029" points="358 392, 358 392, 358 432" position="358 392" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4483" points="358 363" /> <Input id="4286" points="438 426" /> </Inputs> <Outputs> <Output id="4484" /> </Outputs> <Properties> <displayName>C-ter TLR7 dimer binds HCQ</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4715" reactomeId="9679045" points="1073 398, 1072 398, 1119 420" position="1072 398" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2144" points="1049 424" /> <Input id="4717" points="1028 386" /> </Inputs> <Outputs> <Output id="4716" /> </Outputs> <Properties> <displayName>C-ter TLR9 dimer binds HCQ</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.FlowLine id="4718" points="1858 859, 1894 828" position="1876 843" lineWidth="2.0"> <Inputs> <Input id="3987" /> </Inputs> <Outputs> <Output id="1695" /> </Outputs> </org.gk.render.FlowLine> <org.gk.render.RenderableReaction id="4758" reactomeId="9724670" points="277 447, 277 447, 278 446, 320 517" position="278 446" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4759" points="278 387" /> <Input id="4286" points="438 432, 339 405" /> </Inputs> <Outputs> <Output id="4760" /> </Outputs> <Properties> <displayName>C-ter TLR7 dimer binds imiquimod</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="4793" interactionType="Activate" points="1143 679, 909 732, 802 731, 766 692" position="855 731" lineWidth="2.0"> <Inputs> <Input id="1956" /> </Inputs> <Outputs> <Output id="4774" /> </Outputs> <Properties> <displayName>C-ter TLR9 dimer:unmethylated CpG DNA Activates SLC15A4:TASL-dependent IRF5 activation</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="4795" interactionType="Activate" points="413 617, 489 609, 695 609, 714 627" position="592 609" lineWidth="2.0"> <Inputs> <Input id="261" /> </Inputs> <Outputs> <Output id="4774" /> </Outputs> <Properties> <displayName>C-ter TLR7 dimer:TLR7, TLR8 ligands Activates SLC15A4:TASL-dependent IRF5 activation</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Toll-Like Receptors Cascades (500232)
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