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Details on Person UniProt:Q99417 MYCBP
| Class:Id | ReferenceGeneProduct:49960 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-103 added on Fri February 6 2015;initiator methionine:1 for 49960 removed on Fri Nov 03 2023;initiator methionine: for 49960 added on Fri Nov 03 2023;initiator methionine: for 49960 removed on Fri Aug 15 2025;initiator methionine:1 for 49960 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q99417 MYCBP |
| _timestamp | 2026-02-20 22:12:48 |
| chain | initiator methionine:1 chain:2-103 |
| checksum | 72B9BD179A6808D0 |
| comment | FUNCTION May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.SUBUNIT Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84 (PubMed:11483602). Interacts with MYCBPAP (PubMed:12151104). Interacts with CFAP91 (PubMed:12223483). Interacts with CFAP65 in a MYCBPAP-dependent manner (By similarity). Interacts with OTUD4 (PubMed:40215271).INTERACTION Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.TISSUE SPECIFICITY Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.SIMILARITY Belongs to the AMY1 family. |
| description | recommendedName: fullName evidence="7"c-Myc-binding protein alternativeName: Associate of Myc 1 shortName: AMY-1 |
| geneName | MYCBP AMY1 |
| identifier | Q99417 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Direct protein sequencing Mitochondrion Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | MYCBP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989648] ENSEMBL:ENSG00000214114 MYCBP [Homo sapiens] |
| secondaryIdentifier | MYCBP_HUMAN B2R4N0 Q5TA64 Q96HE2 |
| sequenceLength | 103 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9966873] MYCBP [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9969472] MYCBP [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q99417 MYCBP (49960)
