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Details on Person UniProt:P30533 LRPAP1
| Class:Id | ReferenceGeneProduct:49958 |
|---|---|
| _chainChangeLog | signal peptide:1-34 added on Sat February 7 2015;chain:35-357 added on Sat February 7 2015 |
| _displayName | UniProt:P30533 LRPAP1 |
| _timestamp | 2024-11-03 19:59:44 |
| chain | signal peptide:1-34 chain:35-357 |
| checksum | D56A7DA754125CFA |
| comment | FUNCTION Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.SUBUNIT Interacts with the LRP1/alpha-2-macroglobulin receptor heavy and light chains; the interaction is transient and coincides with a reduction of ligand binding by the receptor (PubMed:1400426, PubMed:16678114, PubMed:16938309, PubMed:1712782, PubMed:32296178, PubMed:7774585). Interacts with LRP2/glycoprotein 330 (PubMed:1400426). Interacts with LRP1B; binding is followed by internalization and degradation (PubMed:11384978). Interacts with LDLR (PubMed:16630895). Interacts with SORL1 (PubMed:11294867, PubMed:12530537, PubMed:15053742, PubMed:15364913, PubMed:26858303, PubMed:8940146). Interacts with LRP1; this interaction is followed by rapid internalization (PubMed:15053742).INTERACTION May be associated with receptors at the cell surface.PTM N-glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the alpha-2-MRAP family. |
| description | recommendedName: fullName evidence="22"Alpha-2-macroglobulin receptor-associated protein shortName: Alpha-2-MRAP alternativeName: Low density lipoprotein receptor-related protein-associated protein 1 shortName: RAP |
| geneName | LRPAP1 A2MRAP |
| identifier | P30533 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Coiled coil Direct protein sequencing Endoplasmic reticulum Endosome Glycoprotein Golgi apparatus Heparin-binding Phosphoprotein Proteomics identification Reference proteome Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LRPAP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989369] ENSEMBL:ENSG00000163956 LRPAP1 [Homo sapiens] |
| secondaryIdentifier | AMRP_HUMAN D3DVR9 Q2M310 Q53HQ3 Q53HS6 |
| sequenceLength | 357 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:350199] LRPAP1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P30533 LRPAP1 (49958)
