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Details on Person UniProt:Q01432 AMPD3
| Class:Id | ReferenceGeneProduct:49930 |
|---|---|
| _chainChangeLog | chain:1-767 added on Sat February 7 2015 |
| _displayName | UniProt:Q01432 AMPD3 |
| _timestamp | 2025-02-21 18:33:50 |
| chain | chain:1-767 |
| checksum | 2E0A2C629003B98C |
| comment | FUNCTION AMP deaminase plays a critical role in energy metabolism.CATALYTIC ACTIVITY AMP + H2O + H(+) = IMP + NH4(+)COFACTOR Binds 1 zinc ion per subunit.PATHWAY Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.SUBUNIT Homotetramer.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. |
| description | recommendedName: fullName evidence="13"AMP deaminase 3 ecNumber evidence="7"3.5.4.6 alternativeName: AMP deaminase isoform E alternativeName: Erythrocyte AMP deaminase |
| geneName | AMPD3 |
| identifier | Q01432 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Disease variant Hydrolase Metal-binding Nucleotide metabolism Phosphoprotein Proteomics identification Reference proteome Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | AMPD3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996412] ENSEMBL:ENSG00000133805 AMPD3 [Homo sapiens] |
| secondaryIdentifier | AMPD3_HUMAN A0AUX0 B7Z2S2 B7Z763 B7Z877 |
| sequenceLength | 767 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:143987] UniProt:Q01432-2 AMPD3 [Homo sapiens] [ReferenceIsoform:143988] UniProt:Q01432-3 AMPD3 [Homo sapiens] [ReferenceIsoform:405025] UniProt:Q01432-1 AMPD3 [Homo sapiens] [ReferenceIsoform:8969531] UniProt:Q01432-4 AMPD3 [Homo sapiens] [ReferenceIsoform:8969532] UniProt:Q01432-5 AMPD3 [Homo sapiens] [ReferenceIsoform:8969533] UniProt:Q01432-6 AMPD3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:49929] AMPD3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6801064] AMPD3 [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801077] AMPD3 [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806502] AMPD3 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q01432 AMPD3 (49930)
