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Details on Person UniProt:P05062 ALDOB
| Class:Id | ReferenceGeneProduct:49878 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-364 added on Fri February 6 2015;initiator methionine:1 for 49878 removed on Fri Nov 03 2023;initiator methionine: for 49878 added on Fri Nov 03 2023;initiator methionine: for 49878 removed on Fri Aug 15 2025;initiator methionine:1 for 49878 added on Fri Aug 15 2025 |
| _displayName | UniProt:P05062 ALDOB |
| _timestamp | 2025-08-15 21:20:46 |
| chain | initiator methionine:1 chain:2-364 |
| checksum | DCE314E7AC5586CA |
| comment | FUNCTION Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041).CATALYTIC ACTIVITY beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphateCATALYTIC ACTIVITY beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphateBIOPHYSICOCHEMICAL PROPERTIES Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.PATHWAY Carbohydrate biosynthesis; gluconeogenesis.PATHWAY Carbohydrate metabolism; fructose metabolism.SUBUNIT Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7 (PubMed:18000879). Forms a ternary complex with G6PD and TP53; this interaction is direct (PubMed:35122041).INTERACTION The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.SIMILARITY Belongs to the class I fructose-bisphosphate aldolase family. |
| description | recommendedName: Fructose-bisphosphate aldolase B ecNumber evidence="5 6 11"4.1.2.13 alternativeName: Liver-type aldolase |
| geneName | ALDOB ALDB |
| identifier | P05062 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Glycolysis Lyase Phosphoprotein Proteomics identification Reference proteome Schiff base |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ALDOB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993448] ENSEMBL:ENSG00000136872 ALDOB [Homo sapiens] |
| secondaryIdentifier | ALDOB_HUMAN Q13741 Q13742 Q5T7D6 |
| sequenceLength | 364 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:70339] ALDOB [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5656456] ALDOB A174D [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5656457] ALDOB A149P [cytosol] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:5656449] L-alanine 174 replaced with L-aspartic acid [ReplacedResidue:5656454] L-alanine 149 replaced with L-proline |
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No pathways have been reviewed or authored by UniProt:P05062 ALDOB (49878)
