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Details on Person UniProt:P01876 IGHA1
| Class:Id | ReferenceGeneProduct:49868 |
|---|---|
| _chainChangeLog | chain:-353 added on Fri February 6 2015;chain:1-353 for 49868 removed on Fri May 5 2023;chain:1-398 for 49868 added on Fri May 5 2023 |
| _displayName | UniProt:P01876 IGHA1 |
| _timestamp | 2025-08-15 21:23:26 |
| chain | chain:1-398 |
| checksum | B317D8CD4F29D5F3 |
| comment | FUNCTION Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).SUBUNIT Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked (PubMed:20176268). Monomeric or polymeric (PubMed:2241915). Part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR).SUBCELLULAR LOCATION 3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.PTM N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.POLYMORPHISM There are several alleles. The sequence shown is that of IMGT allele IGHA1*02.DISEASE A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.CAUTION For an example of a full-length immunoglobulin alpha heavy chain see AC P0DOX2.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: fullName evidence="15 20"Immunoglobulin heavy constant alpha 1 alternativeName: fullName evidence="21"Ig alpha-1 chain C region alternativeName: fullName evidence="22"Ig alpha-1 chain C region BUR alternativeName: fullName evidence="23"Ig alpha-1 chain C region TRO |
| geneName | IGHA1 |
| identifier | P01876 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Adaptive immunity Alternative splicing Cell membrane Chromophore Chromosomal rearrangement Direct protein sequencing Disulfide bond Glycoprotein Immunity Immunoglobulin Immunoglobulin domain Membrane Proteomics identification Reference proteome Secreted Transmembrane Transmembrane helix |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | IGHA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958510] ENSEMBL:ENSG00000211895 IGHA1 [Homo sapiens] [ReferenceDNASequence:8958182] ENSEMBL:ENSG00000282633 IGHA1 [Homo sapiens] |
| secondaryIdentifier | IGHA1_HUMAN A0A286YEY1 |
| sequenceLength | 398 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:9834116] UniProt:P01876-1 IGHA1 [Homo sapiens] [ReferenceIsoform:9834117] UniProt:P01876-2 IGHA1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:1478809] IGHA1 [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P01876 IGHA1 (49868)
