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Details on Person UniProt:P02768 ALB
| Class:Id | ReferenceGeneProduct:49866 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Sat February 7 2015;propeptide:19-22 added on Sat February 7 2015;chain:25-609 added on Sat February 7 2015;propeptide:19-22 removed on Wed November 4 2015;propeptide:19-24 added on Wed November 4 2015 |
| _displayName | UniProt:P02768 ALB |
| _timestamp | 2024-11-03 20:13:11 |
| chain | signal peptide:1-18 propeptide:19-24 chain:25-609 |
| checksum | F88FF61DD242E818 |
| comment | FUNCTION Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017).SUBUNIT Interacts with FCGRT; this interaction regulates ALB homeostasis (PubMed:28330995). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin with molar ratio 1:2 and 1:1; this interaction does not prevent fatty acid binding to ALB.INTERACTION Plasma.PTM Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.PTM Glycated in diabetic patients.PTM Phosphorylated by FAM20C in the extracellular medium.PTM Acetylated on Lys-223 by acetylsalicylic acid.POLYMORPHISM A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ALB/AFP/VDB family.CAUTION A peptide arising from positions 166 to 174 was originally (PubMed:3087352, PubMed:2437111) termed neurotensin-related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and blood flow.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION Serum albumin entry |
| description | recommendedName: Albumin |
| geneName | ALB GIG20 GIG42 PRO0903 PRO1708 PRO2044 PRO2619 PRO2675 UNQ696/PRO1341 |
| identifier | P02768 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Cleavage on pair of basic residues Copper Direct protein sequencing Disease variant Disulfide bond Glycation Glycoprotein Lipid-binding Metal-binding Methylation Phosphoprotein Proteomics identification Reference proteome Repeat Secreted Signal Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ALB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957776] ENSEMBL:ENSG00000163631 ALB [Homo sapiens] |
| secondaryIdentifier | ALBU_HUMAN E7ESS9 O95574 P04277 Q13140 Q645G4 Q68DN5 Q6UXK4 Q86YG0 Q8IUK7 Q9P157 Q9P1I7 Q9UHS3 Q9UJZ0 |
| sequenceLength | 609 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:218387] UniProt:P02768-2 ALB [Homo sapiens] [ReferenceIsoform:402305] UniProt:P02768-1 ALB [Homo sapiens] [ReferenceIsoform:8971785] UniProt:P02768-3 ALB [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:49865] ALB [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:114609] ALB(19-609) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:194115] ALB [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8956690] ALB [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:8956930] p-ALB [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:9749660] acetyl-ALB [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9750694] salicyl-ALB [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8957073] phosphorylated residue at unknown position [ModifiedResidue:9749570] N6-acetyl-L-lysine at 223 [ModifiedResidue:9749653] N6-acetyl-L-lysine at 543 [GroupModifiedResidue:9750698] uncategorized protein modification (uncategorized protein modification) at unknown position |
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No pathways have been reviewed or authored by UniProt:P02768 ALB (49866)
