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Details on Person UniProt:P24298 GPT
| Class:Id | ReferenceGeneProduct:49864 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-496 added on Fri February 6 2015;initiator methionine:1 for 49864 removed on Fri Nov 03 2023;initiator methionine: for 49864 added on Fri Nov 03 2023;initiator methionine: for 49864 removed on Fri Aug 15 2025;initiator methionine:1 for 49864 added on Fri Aug 15 2025 |
| _displayName | UniProt:P24298 GPT |
| _timestamp | 2025-08-15 21:05:14 |
| chain | initiator methionine:1 chain:2-496 |
| checksum | 23705E7A3A4283B6 |
| comment | FUNCTION Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).CATALYTIC ACTIVITY L-alanine + 2-oxoglutarate = pyruvate + L-glutamateCOFACTOR Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.SUBUNIT Homodimer.SUBCELLULAR LOCATION Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue.INDUCTION By glucocorticoids.SIMILARITY Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.ONLINE INFORMATION Alanine transaminase entry |
| description | recommendedName: Alanine aminotransferase 1 shortName: ALT1 ecNumber: 2.6.1.2 alternativeName: Glutamate pyruvate transaminase 1 shortName: GPT 1 alternativeName: Glutamic--alanine transaminase 1 alternativeName: Glutamic--pyruvic transaminase 1 |
| geneName | GPT AAT1 GPT1 |
| identifier | P24298 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Aminotransferase Cytoplasm Direct protein sequencing Phosphoprotein Proteomics identification Pyridoxal phosphate Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GPT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002794] ENSEMBL:ENSG00000167701 GPT [Homo sapiens] |
| secondaryIdentifier | ALAT1_HUMAN B0YJ18 D3DWM7 P78398 Q93076 |
| sequenceLength | 496 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:70520] PXLP-K314-GPT [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:508047] N6-pyridoxal phosphate-L-lysine at 314 |
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No pathways have been reviewed or authored by UniProt:P24298 GPT (49864)
