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Details on Person UniProt:Q9Y2D5 PALM2AKAP2
Class:Id
ReferenceGeneProduct:49834
_chainChangeLog
chain:1-859 added on Fri February 6 2015;chain:1-859 for 49834 removed on Mon Feb 26 2024;chain:1-1103 for 49834 added on Mon Feb 26 2024
_displayName
UniProt:Q9Y2D5 PALM2AKAP2
_timestamp
2026-02-20 22:02:42
chain
chain:1-1103
checksum
B501182135112FE5
comment
FUNCTION Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton.SUBCELLULAR LOCATION Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons.ALTERNATIVE PRODUCTS Expressed in infantile heart and muscle, and fibroblasts.DOMAIN The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.MISCELLANEOUS Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.MISCELLANEOUS Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus.
description
recommendedName: fullName evidence="9"PALM2-AKAP2 fusion protein alternativeName: A-kinase anchor protein 2 shortName: AKAP-2 alternativeName: AKAP-KL alternativeName: fullName evidence="1"Paralemmin A kinase anchor protein alternativeName: fullName evidence="8"Paralemmin-2 alternativeName: Protein kinase A-anchoring protein 2 shortName: PRKA2
geneName
PALM2AKAP2 KIAA0920 PAKAP PALM2
identifier
Q9Y2D5
isSequenceChanged
FALSE
keyword
Alternative splicing Cell membrane Coiled coil Glycoprotein GPI-anchor Isopeptide bond Lipoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Ubl conjugation
