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Details on Person UniProt:Q13015 MLLT11
| Class:Id | ReferenceGeneProduct:49756 |
|---|---|
| _chainChangeLog | chain:1-90 added on Fri February 6 2015 |
| _displayName | UniProt:Q13015 MLLT11 |
| _timestamp | 2024-11-03 20:04:16 |
| chain | chain:1-90 |
| checksum | B37C6F7303C9EBF8 |
| comment | FUNCTION Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).SUBUNIT Interacts with HSPA8 and LAMP2 isoform A; the interaction may target MLLT11 for degradation via chaperone-mediated autophagy (PubMed:24880125). Interacts with TCF7 (PubMed:26079538).INTERACTION Continuous nuclear export is followed by degradation.TISSUE SPECIFICITY Expressed in myoepithelial cells of normal breast tissue (at protein level) (PubMed:26079538). Highly expressed in thymus (PubMed:7833468). Expressed in colon, small intestine, prostate and ovary. Not detected in peripheral blood lymphocytes and spleen (PubMed:7833468).PTM Ubiquitinated, leading to degradation.DISEASE A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.SIMILARITY Belongs to the MLLT11 family. |
| description | recommendedName: Protein AF1q |
| geneName | MLLT11 AF1Q |
| identifier | Q13015 |
| isSequenceChanged | FALSE |
| keyword | Chromosomal rearrangement Cytoplasm Cytoskeleton Nucleus Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MLLT11 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992294] ENSEMBL:ENSG00000213190 MLLT11 [Homo sapiens] |
| secondaryIdentifier | AF1Q_HUMAN |
| sequenceLength | 90 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9965424] MLLT11 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q13015 MLLT11 (49756)
