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Details on Person UniProt:P55198 MLLT6
Class:Id
ReferenceGeneProduct:49754
_chainChangeLog
chain:1-1093 added on Fri February 6 2015
_displayName
UniProt:P55198 MLLT6
_timestamp
2024-11-03 19:59:40
chain
chain:1-1093
checksum
C55F0801D9A0A5C1
comment
SUBUNIT Interacts with histone H3; interaction is necessary for MLLT6 binding to nucleosomes; interaction is inhibited by histone H3 'Lys-27' methylations (H3K27me1, H3K27me2 and H3K27me3).INTERACTION A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation t(11;17)(q23;q21) with KMT2A/MLL1. The result is a rogue activator protein.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
description
recommendedName: Protein AF-17 alternativeName: ALL1-fused gene from chromosome 17 protein
