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Details on Person UniProt:P35318 ADM
| Class:Id | ReferenceGeneProduct:49728 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Sat February 7 2015;peptide:22-41 added on Sat February 7 2015;propeptide:45-92 added on Sat February 7 2015;peptide:95-146 added on Sat February 7 2015;propeptide:148-185 added on Sat February 7 2015;peptide:30-41 for 49728 added on Fri Feb 20 2026 |
| _displayName | UniProt:P35318 ADM |
| _timestamp | 2026-02-20 22:18:39 |
| chain | signal peptide:1-21 peptide:22-41 peptide:30-41 propeptide:45-92 peptide:95-146 propeptide:148-185 |
| checksum | 64C7D2A0B4654DFE |
| comment | FUNCTION Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.FUNCTION Peptide hormone that act as potent hypotensive and vasodilatator agents (PubMed:8387282). ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex (PubMed:32296767, PubMed:9620797).FUNCTION Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563).FUNCTION Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563, PubMed:34789875).SUBCELLULAR LOCATION Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.SIMILARITY Belongs to the adrenomedullin family. |
| description | recommendedName: Pro-adrenomedullin component recommendedName: fullName evidence="14"Adrenomedullin shortName: AM /component component recommendedName: fullName evidence="2"Proadrenomedullin N-20 terminal peptide alternativeName: fullName evidence="13"ProAM N-terminal 20 peptide shortName evidence="13"PAMP shortName: ProAM-N20 /component component recommendedName: fullName evidence="12"Proadrenomedullin 9-20 terminal peptide shortName evidence="12"PAMP-12 /component |
| geneName | ADM AM |
| identifier | P35318 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ADM |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991702] ENSEMBL:ENSG00000148926 ADM [Homo sapiens] |
| secondaryIdentifier | ADML_HUMAN B2R793 D3DQV3 Q6FGW2 |
| sequenceLength | 185 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:420093] ADM(95-146) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9861342] ADM(95-146) [secretory granule lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P35318 ADM (49728)
