Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P28332 ADH6
| Class:Id | ReferenceGeneProduct:49712 |
|---|---|
| _chainChangeLog | chain:1-368 added on Fri February 6 2015 |
| _displayName | UniProt:P28332 ADH6 |
| _timestamp | 2025-02-21 19:24:58 |
| chain | chain:1-368 |
| checksum | EC8E81E9571E6241 |
| comment | FUNCTION Alcohol dehydrogenase (PubMed:1755855). Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes (PubMed:1755855). Oxidizes secondary alcohols to the corresponding ketones (By similarity).CATALYTIC ACTIVITY a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)CATALYTIC ACTIVITY a secondary alcohol + NAD(+) = a ketone + NADH + H(+)COFACTOR Binds 2 Zn(2+) ions per subunit.ACTIVITY REGULATION Inhibited partially by pyrazole (10 mM) in the reaction mixture containing 100 mM ethanol at pH 10.0.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 10.0.SUBUNIT Dimer.SUBCELLULAR LOCATION Stomach and liver.MISCELLANEOUS There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.MISCELLANEOUS Isoelectric point (pH(I)) is 8.6.SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. Class-V subfamily. |
| description | recommendedName: Alcohol dehydrogenase 6 ecNumber evidence="3"1.1.1.1 |
| geneName | ADH6 |
| identifier | P28332 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Metal-binding NAD Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ADH6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991117] ENSEMBL:ENSG00000172955 ADH6 [Homo sapiens] |
| secondaryIdentifier | ADH6_HUMAN A0A0A0MS56 B3KS45 Q58F53 |
| sequenceLength | 368 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:436087] UniProt:P28332-1 ADH6 [Homo sapiens] [ReferenceIsoform:436088] UniProt:P28332-2 ADH6 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:71747] ADH6 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P28332 ADH6 (49712)
