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Details on Person UniProt:O00116 AGPS
| Class:Id | ReferenceGeneProduct:49700 |
|---|---|
| _chainChangeLog | transit peptide:1-58 added on Sat February 7 2015;chain:59-658 added on Sat February 7 2015 |
| _displayName | UniProt:O00116 AGPS |
| _timestamp | 2025-02-21 18:33:35 |
| chain | transit peptide:1-58 chain:59-658 |
| checksum | 0E97AE86B513DF32 |
| comment | FUNCTION Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.CATALYTIC ACTIVITY a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)CATALYTIC ACTIVITY hexadecan-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)CATALYTIC ACTIVITY 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoateCOFACTOR Glycerolipid metabolism; ether lipid biosynthesis.SUBUNIT Homodimer.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the FAD-binding oxidoreductase/transferase type 4 family. |
| description | recommendedName: Alkyldihydroxyacetonephosphate synthase, peroxisomal shortName: Alkyl-DHAP synthase ecNumber evidence="8 9"2.5.1.26 alternativeName: Aging-associated gene 5 protein alternativeName: Alkylglycerone-phosphate synthase |
| geneName | AGPS AAG5 |
| identifier | O00116 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cataract Disease variant Dwarfism FAD Flavoprotein Lipid biosynthesis Lipid metabolism Membrane Peroxisome Phosphoprotein Proteomics identification Reference proteome Rhizomelic chondrodysplasia punctata Transferase Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | AGPS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002187] ENSEMBL:ENSG00000018510 AGPS [Homo sapiens] |
| secondaryIdentifier | ADAS_HUMAN A5D8U9 Q2TU35 |
| sequenceLength | 658 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:49699] AGPS [peroxisomal matrix] [Homo sapiens] [EntityWithAccessionedSequence:9033119] AGPS(1-658) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9033519] AGPS(1-58) [peroxisomal matrix] [Homo sapiens] [EntityWithAccessionedSequence:9033523] AGPS(1-658) [peroxisomal matrix] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O00116 AGPS (49700)
