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Details on Person UniProt:Q99965 ADAM2
| Class:Id | ReferenceGeneProduct:49658 |
|---|---|
| _chainChangeLog | signal peptide:1-16 added on Sat February 7 2015;propeptide:17-174 added on Sat February 7 2015;chain:175-735 added on Sat February 7 2015 |
| _displayName | UniProt:Q99965 ADAM2 |
| _timestamp | 2024-08-09 19:45:42 |
| chain | signal peptide:1-16 propeptide:17-174 chain:175-735 |
| checksum | 92867B5340BEE01F |
| comment | FUNCTION Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.SUBCELLULAR LOCATION Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.DOMAIN A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.PTM The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.MISCELLANEOUS In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene. |
| description | recommendedName: Disintegrin and metalloproteinase domain-containing protein 2 shortName: ADAM 2 alternativeName: Cancer/testis antigen 15 shortName: CT15 alternativeName: Fertilin subunit beta alternativeName: PH-30 shortName: PH30 alternativeName: PH30-beta |
| geneName | ADAM2 FTNB |
| identifier | Q99965 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell adhesion Disulfide bond EGF-like domain Glycoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | ADAM2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003958] ENSEMBL:ENSG00000104755 ADAM2 [Homo sapiens] |
| secondaryIdentifier | ADAM2_HUMAN P78326 Q9UQQ8 |
| sequenceLength | 735 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:143829] UniProt:Q99965-2 ADAM2 [Homo sapiens] [ReferenceIsoform:413186] UniProt:Q99965-1 ADAM2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:508394] ADAM2 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q99965 ADAM2 (49658)
