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Details on Person UniProt:P68138 ACTA1
| Class:Id | ReferenceGeneProduct:49637 |
|---|---|
| _chainChangeLog | propeptide:1-2 added on Fri February 6 2015;chain:3-377 added on Fri February 6 2015;initiator methionine:1 for 49637 removed on Fri Nov 03 2023;initiator methionine: for 49637 added on Fri Nov 03 2023;initiator methionine: for 49637 removed on Fri Aug 15 2025;initiator methionine:1 for 49637 added on Fri Aug 15 2025 |
| _displayName | UniProt:P68138 ACTA1 |
| _timestamp | 2025-08-15 21:20:34 |
| chain | initiator methionine:1 chain:2-377 chain:3-377 |
| checksum | DF2A3A046346A179 |
| comment | FUNCTION Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with alpha-actinin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with TTID. Interacts (via its C-terminus) with USP25 (By similarity).SUBCELLULAR LOCATION N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.PTM Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.PTM Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.PTM Methylated at His-75 by SETD3.MISCELLANEOUS In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.SIMILARITY Belongs to the actin family. |
| description | recommendedName: Actin, alpha skeletal muscle ecNumber evidence="6"3.6.4.- alternativeName: Alpha-actin-1 component recommendedName: Actin, alpha skeletal muscle, intermediate form /component |
| geneName | ACTA1 ACTA |
| identifier | P68138 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Cytoplasm Cytoskeleton Direct protein sequencing Hydrolase Methylation Muscle protein Nucleotide-binding Oxidation Reference proteome |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618410] Weiser, JD [InstanceEdit:5618413] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ACTA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ACTS_BOVIN P02568 P99020 Q3ZCG3 |
| sequenceLength | 377 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:9913726] ACTA1 [cytosol] [Bos taurus] |
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No pathways have been reviewed or authored by UniProt:P68138 ACTA1 (49637)
