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Details on Person UniProt:Q9NR19 ACSS2
| Class:Id | ReferenceGeneProduct:49564 |
|---|---|
| _chainChangeLog | chain:1-701 added on Sat February 7 2015 |
| _displayName | UniProt:Q9NR19 ACSS2 |
| _timestamp | 2025-02-21 18:53:56 |
| chain | chain:1-701 |
| checksum | 833580B41B73A8B4 |
| comment | FUNCTION Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429, PubMed:28552616). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis (PubMed:28552616). Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription (PubMed:28552616). The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival (PubMed:28552616). Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (By similarity).CATALYTIC ACTIVITY acetate + ATP + CoA = acetyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphateACTIVITY REGULATION Inhibited by acetylation at Lys-661 and activated by deacetylation mediated by the deacetylases SIRT1 and SIRT3.SUBUNIT Monomer (PubMed:10843999). Interacts with TFEB (PubMed:28552616). AMPK-mediated phosphorylated form at Ser-659 interacts with KPNA1; this interaction results in nuclear translocation of ACSS2 (PubMed:28552616). Interacts with the 'Thr-172' phosphorylated form of PRKAA2 (PubMed:28552616). Interacts with CREBBP (By similarity).SUBCELLULAR LOCATION Glucose deprivation results in its AMPK-dependent phosphorylation and subsequent nuclear translocation (PubMed:28552616). Phosphorylation at Ser-659, leads to exposure of its nuclear localization signal which is required for its interaction with KPNA1 and subsequent translocation to the nucleus (PubMed:28552616). Found in the cytoplasm in undifferentiated neurons and upon differentiation, translocates to nucleus (By similarity).ALTERNATIVE PRODUCTS Reversibly acetylated at Lys-661 (By similarity). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylases SIRT1 and SIRT3 (By similarity).PTM Glucose deprivation results in its AMPK-dependent phosphorylation at Ser-659, which leads to exposure of its nuclear localization signal, required for its interaction with KPNA1 and subsequent translocation to the nucleus.SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family. |
| description | recommendedName: Acetyl-coenzyme A synthetase, cytoplasmic ecNumber evidence="4 5 6"6.2.1.1 alternativeName: Acetate--CoA ligase alternativeName: Acetyl-CoA synthetase shortName: ACS shortName: AceCS alternativeName: fullName evidence="2"Acetyl-CoA synthetase 1 shortName evidence="2"AceCS1 alternativeName: Acyl-CoA synthetase short-chain family member 2 alternativeName: Acyl-activating enzyme alternativeName: Propionate--CoA ligase ecNumber evidence="2"6.2.1.17 |
| geneName | ACSS2 ACAS2 |
| identifier | Q9NR19 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Activator Alternative splicing ATP-binding Cytoplasm Ligase Lipid metabolism Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ACSS2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003363] ENSEMBL:ENSG00000131069 ACSS2 [Homo sapiens] |
| secondaryIdentifier | ACSA_HUMAN A6NE90 Q5QPH2 Q5QPH3 Q8N238 Q96EL0 Q9NQP7 Q9UJ15 |
| sequenceLength | 701 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8972278] UniProt:Q9NR19-1 ACSS2 [Homo sapiens] [ReferenceIsoform:8972279] UniProt:Q9NR19-2 ACSS2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:71733] ACSS2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5688284] AcK-ACSS2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:5688311] ACSS2 [mitochondrial matrix] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:5688296] N6-acetyl-L-lysine at 418 |
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No pathways have been reviewed or authored by UniProt:Q9NR19 ACSS2 (49564)
