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Details on Person UniProt:P10323 ACR
Class:Id
ReferenceGeneProduct:49562
_chainChangeLog
signal peptide:1-19 added on Sat February 7 2015;chain:20-421 added on Sat February 7 2015;chain:20-42 added on Sat February 7 2015;chain:43-343 added on Sat February 7 2015;propeptide:344-421 added on Sat February 7 2015
_displayName
UniProt:P10323 ACR
_timestamp
2024-11-03 19:44:30
chain
signal peptide:1-19 chain:20-421 chain:20-42 chain:43-343 propeptide:344-421
checksum
7A2F7ECEC98008FA
comment
FUNCTION Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.CATALYTIC ACTIVITY Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.ACTIVITY REGULATION Inhibited by SERPINA5.SUBUNIT Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with SERPINA5.INTERACTION The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase S1 family.
