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Details on Person UniProt:P20309 CHRM3
| Class:Id | ReferenceGeneProduct:49544 |
|---|---|
| _chainChangeLog | chain:1-590 added on Fri February 6 2015 |
| _displayName | UniProt:P20309 CHRM3 |
| _timestamp | 2024-11-03 20:17:43 |
| chain | chain:1-590 |
| checksum | 5CB473C57B9526E9 |
| comment | FUNCTION The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.SUBUNIT Homodimer; the dimers can form tetramers (PubMed:23521066). Interacts with NALCN (By similarity). Interacts with TMEM147 (PubMed:21056967).INTERACTION Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily. |
| description | recommendedName: Muscarinic acetylcholine receptor M3 |
| geneName | CHRM3 |
| identifier | P20309 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond Endoplasmic reticulum G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Postsynaptic cell membrane Proteomics identification Receptor Reference proteome Synapse Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CHRM3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992875] ENSEMBL:ENSG00000133019 CHRM3 [Homo sapiens] |
| secondaryIdentifier | ACM3_HUMAN Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 |
| sequenceLength | 590 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:399994] CHRM3 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P20309 CHRM3 (49544)
