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Details on Person UniProt:P08172 CHRM2
| Class:Id | ReferenceGeneProduct:49542 |
|---|---|
| _chainChangeLog | chain:1-466 added on Sat February 7 2015 |
| _displayName | UniProt:P08172 CHRM2 |
| _timestamp | 2026-02-20 22:51:41 |
| chain | chain:1-466 |
| checksum | 2FC2FD7748C22BEC |
| comment | FUNCTION Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia (PubMed:24256733, PubMed:3443095, PubMed:36690613). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:36690613). CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity (PubMed:36690613).ACTIVITY REGULATION Activated by allosteric modulator LY2119620.SUBUNIT Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of the receptor and short-term desensitization to the ligand (PubMed:38175886, PubMed:7822302). Interacts with RACK1; the interaction regulates CHRM2 internalization (PubMed:20976005).SUBCELLULAR LOCATION Phosphorylation in response to agonist binding promotes receptor internalization.INDUCTION Up-regulated in response to enterovirus 71 (EV71) infection.DOMAIN The P-X-P-P motif is phosphorylated in response to ligand binding, promoting. association with beta-arrestin (ARRB1 and/or ARRB2).PTM Phosphorylation of the P-X-P-P motif promotes association with beta-arrestin (ARRB1 and/or ARRB2), leading to receptor desensitization and negative regulation of G-protein coupled receptor signaling.POLYMORPHISM Genetic variations in CHRM2 can influence susceptibility to alcoholism [MIM:103780].DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily. |
| description | recommendedName: Muscarinic acetylcholine receptor M2 |
| geneName | CHRM2 |
| identifier | P08172 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Postsynaptic cell membrane Proteomics identification Receptor Reference proteome Synapse Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CHRM2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001003] ENSEMBL:ENSG00000181072 CHRM2 [Homo sapiens] |
| secondaryIdentifier | ACM2_HUMAN Q4VBK6 Q9P1X9 |
| sequenceLength | 466 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:390654] CHRM2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8869085] CHRM2 [clathrin-coated endocytic vesicle membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P08172 CHRM2 (49542)
