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Details on Person UniProt:P11229 CHRM1
| Class:Id | ReferenceGeneProduct:49540 |
|---|---|
| _chainChangeLog | chain:1-460 added on Fri February 6 2015 |
| _displayName | UniProt:P11229 CHRM1 |
| _timestamp | 2024-11-03 19:59:38 |
| chain | chain:1-460 |
| checksum | 567C20F63541C8D0 |
| comment | FUNCTION The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.SUBUNIT Interacts with GPRASP2 (PubMed:15086532). Interacts with TMEM147 (PubMed:21056967).SUBCELLULAR LOCATION Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily. |
| description | recommendedName: Muscarinic acetylcholine receptor M1 |
| geneName | CHRM1 |
| identifier | P11229 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Postsynaptic cell membrane Proteomics identification Receptor Reference proteome Synapse Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CHRM1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990526] ENSEMBL:ENSG00000168539 CHRM1 [Homo sapiens] |
| secondaryIdentifier | ACM1_HUMAN Q96RH1 |
| sequenceLength | 460 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973152] UniProt:P11229-1 CHRM1 [Homo sapiens] [ReferenceIsoform:8973153] UniProt:P11229-2 CHRM1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:390628] CHRM1 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P11229 CHRM1 (49540)
