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Details on Person UniProt:P11230 CHRNB1
Class:Id
ReferenceGeneProduct:49520
_chainChangeLog
signal peptide:1-23 added on Fri February 6 2015;chain:24-501 added on Fri February 6 2015
_displayName
UniProt:P11230 CHRNB1
_timestamp
2026-02-20 21:56:27
chain
signal peptide:1-23 chain:24-501
checksum
365CBFA795A51394
comment
FUNCTION After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.CATALYTIC ACTIVITY K(+)(in) = K(+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)SUBUNIT Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (PubMed:15609996).INTERACTION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily.
3D-structure Alternative splicing Cell membrane Congenital myasthenic syndrome Disease variant Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Phosphoprotein Postsynaptic cell membrane Proteomics identification Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport
