Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P40937 RFC5
| Class:Id | ReferenceGeneProduct:49468 |
|---|---|
| _chainChangeLog | chain:1-340 added on Fri February 6 2015 |
| _displayName | UniProt:P40937 RFC5 |
| _timestamp | 2025-05-21 21:58:03 |
| chain | chain:1-340 |
| checksum | E31E7B8C79933BCE |
| comment | FUNCTION Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA.SUBUNIT Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA (PubMed:8999859, PubMed:9488738). Forms an heterotetrameric complex with RFC2, RFC3 and RFC4; this complex has ATPase activity but is not stimulated by PCNA (PubMed:9488738). The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17 (PubMed:11572977).INTERACTION Belongs to the activator 1 small subunits family. |
| description | recommendedName: Replication factor C subunit 5 alternativeName: Activator 1 36 kDa subunit shortName: A1 36 kDa subunit alternativeName: Activator 1 subunit 5 alternativeName: Replication factor C 36 kDa subunit shortName: RF-C 36 kDa subunit shortName: RFC36 |
| geneName | RFC5 |
| identifier | P40937 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding DNA replication Nucleotide-binding Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | RFC5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001394] ENSEMBL:ENSG00000111445 RFC5 [Homo sapiens] |
| secondaryIdentifier | RFC5_HUMAN A8MZ62 B3KSX8 |
| sequenceLength | 340 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966252] UniProt:P40937-1 RFC5 [Homo sapiens] [ReferenceIsoform:8966253] UniProt:P40937-2 RFC5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68427] RFC5 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P40937 RFC5 (49468)
