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Details on Person UniProt:P61222 Abce1
| Class:Id | ReferenceGeneProduct:49438 |
|---|---|
| _chainChangeLog | chain:1-599 added on Fri February 6 2015 |
| _displayName | UniProt:P61222 Abce1 |
| _timestamp | 2025-02-21 19:35:06 |
| chain | chain:1-599 |
| checksum | 5D582B62E95BC7A6 |
| comment | FUNCTION Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (By similarity). Able to hydrolyze ATP, GTP, UTP and CTP (By similarity). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (By similarity). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (By similarity). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (By similarity). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (By similarity). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (By similarity). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:10866653). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)CATALYTIC ACTIVITY CTP + H2O = CDP + phosphate + H(+)CATALYTIC ACTIVITY UTP + H2O = UDP + phosphate + H(+)SUBUNIT Interacts with PINK1. Interacts with CNOT4. Interacts with PELO. Probably heterodimerizes with RNASEL; this interaction inhibits RNASEL.SUBCELLULAR LOCATION Ubiquitinated by CNOT4 (By similarity). Ubiquitination mediates the recruitment of autophagy receptors to the mitochondrial outer membrane and initiates mitophagy (By similarity).SIMILARITY Belongs to the ABC transporter superfamily. ABCE family. |
| description | recommendedName: ATP-binding cassette sub-family E member 1 alternativeName: fullName evidence="5"RNase L inhibitor ecNumber evidence="1"3.6.5.- alternativeName: fullName evidence="5"Ribonuclease 4 inhibitor shortName evidence="5"RNS4I |
| geneName | Abce1 Rli |
| identifier | P61222 |
| isSequenceChanged | FALSE |
| keyword | 4Fe-4S ATP-binding Chaperone Cytoplasm Hydrolase Iron Iron-sulfur Metal-binding Mitochondrion Nucleotide-binding Phosphoprotein Reference proteome Repeat Translation regulation Ubl conjugation |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Abce1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ABCE1_MOUSE O88793 Q13181 Q13864 Q96AL0 Q96B10 Q99K66 |
| sequenceLength | 599 |
| species | [Species:48892] Mus musculus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P61222 Abce1 (49438)
