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Details on Person UniProt:O43741 PRKAB2
| Class:Id | ReferenceGeneProduct:49386 |
|---|---|
| _chainChangeLog | chain:1-272 added on Fri February 6 2015 |
| _displayName | UniProt:O43741 PRKAB2 |
| _timestamp | 2024-11-03 20:08:40 |
| chain | chain:1-272 |
| checksum | 42B23BD70B92519C |
| comment | FUNCTION Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).SUBUNIT AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3).INTERACTION Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.SIMILARITY Belongs to the 5'-AMP-activated protein kinase beta subunit family. |
| description | recommendedName: 5'-AMP-activated protein kinase subunit beta-2 shortName: AMPK subunit beta-2 |
| geneName | PRKAB2 |
| identifier | O43741 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PRKAB2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003357] ENSEMBL:ENSG00000131791 PRKAB2 [Homo sapiens] |
| secondaryIdentifier | AAKB2_HUMAN A8K9V5 B4DH06 Q5VXY0 |
| sequenceLength | 272 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977273] UniProt:O43741-1 PRKAB2 [Homo sapiens] [ReferenceIsoform:8977274] UniProt:O43741-2 PRKAB2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:164096] PRKAB2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:200413] PRKAB2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9931271] PRKAB2 [endoplasmic reticulum lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43741 PRKAB2 (49386)
