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Details on Person UniProt:P01011 SERPINA3
| Class:Id | ReferenceGeneProduct:49378 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Sat February 7 2015;chain:24-423 added on Sat February 7 2015;chain:26-423 added on Sat February 7 2015 |
| _displayName | UniProt:P01011 SERPINA3 |
| _timestamp | 2024-11-03 19:49:42 |
| chain | signal peptide:1-23 chain:24-423 chain:26-423 |
| checksum | B002F946C86A8951 |
| comment | FUNCTION Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.SUBUNIT Interacts with DNAJC1.INTERACTION Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.DOMAIN The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.PTM N- and O-glycosylated.MISCELLANEOUS Alpha-1-antichymotrypsin can bind DNA.SIMILARITY Belongs to the serpin family.CAUTION It is uncertain whether Met-1 or Met-4 is the initiator.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.ONLINE INFORMATION Alpha-1 antichymotrypsin entry |
| description | recommendedName: Alpha-1-antichymotrypsin shortName: ACT alternativeName: Cell growth-inhibiting gene 24/25 protein alternativeName: Serpin A3 component recommendedName: Alpha-1-antichymotrypsin His-Pro-less /component |
| geneName | SERPINA3 AACT GIG24 GIG25 |
| identifier | P01011 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acute phase Alternative splicing Direct protein sequencing Glycoprotein Protease inhibitor Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SERPINA3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998716] ENSEMBL:ENSG00000196136 SERPINA3 [Homo sapiens] |
| secondaryIdentifier | AACT_HUMAN B3KVQ7 Q13703 Q2TU87 Q2TU88 Q59GP9 Q6LBY8 Q6LDT7 Q6NSC9 Q8N177 Q96DW8 Q9UC47 Q9UNU9 |
| sequenceLength | 423 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:217527] UniProt:P01011-2 SERPINA3 [Homo sapiens] [ReferenceIsoform:217528] UniProt:P01011-3 SERPINA3 [Homo sapiens] [ReferenceIsoform:402238] UniProt:P01011-1 SERPINA3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6798754] SERPINA3 [azurophil granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801018] SERPINA3 [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806173] SERPINA3 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8848913] SERPINA3 [platelet alpha granule lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P01011 SERPINA3 (49378)
