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Details on Person UniProt:O43707 ACTN4
| Class:Id | ReferenceGeneProduct:49376 |
|---|---|
| _chainChangeLog | chain:1-911 added on Sat February 7 2015 |
| _displayName | UniProt:O43707 ACTN4 |
| _timestamp | 2025-08-15 21:28:05 |
| chain | chain:1-911 |
| checksum | 461580C3F22937D1 |
| comment | FUNCTION F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882).SUBUNIT Homodimer; antiparallel. Binds TRIM3 at the N-terminus (PubMed:15772161). Interacts with MICALL2 (preferentially in opened conformation); stimulated by RAB13 activation (By similarity). Identified in a complex with CASK, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3 (PubMed:15772161). Interacts with MAGI1 (PubMed:12042308). Interacts with PDLIM2 (By similarity). Interacts with PPARG and RARA (PubMed:22351778). Binds to VCL; this interaction triggers VCL conformational changes (PubMed:15988023). Interacts with SEPTIN14 (PubMed:33228246). Interacts with IGSF8 (PubMed:22689882).INTERACTION Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7).ALTERNATIVE PRODUCTS Widely expressed.DOMAIN Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif that mediates interaction with nuclear receptors.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Does not colocalize with actin cytoskeleton structures.SIMILARITY Belongs to the alpha-actinin family.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: fullName evidence="26"Alpha-actinin-4 alternativeName: fullName evidence="23"Non-muscle alpha-actinin 4 |
| geneName | ACTN4 |
| identifier | O43707 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Alternative splicing Calcium Cell junction Cytoplasm Cytoskeleton Disease variant Metal-binding Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Transport |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ACTN4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958375] ENSEMBL:ENSG00000130402 ACTN4 [Homo sapiens] [ReferenceDNASequence:8958625] ENSEMBL:ENSG00000282844 ACTN4 [Homo sapiens] |
| secondaryIdentifier | ACTN4_HUMAN A4K467 D6PXK4 O76048 |
| sequenceLength | 911 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974147] UniProt:O43707-1 ACTN4 [Homo sapiens] [ReferenceIsoform:8974148] UniProt:O43707-2 ACTN4 [Homo sapiens] [ReferenceIsoform:8974149] UniProt:O43707-3 ACTN4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:198240] ACTN4 [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:349729] ACTN4 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:390558] ACTN4 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43707 ACTN4 (49376)
