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Details on Person UniProt:Q9NS82 SLC7A10

Class:IdReferenceGeneProduct:49362
_chainChangeLogchain:1-523 added on Fri February 6 2015
_displayNameUniProt:Q9NS82 SLC7A10
_timestamp2025-08-15 21:27:58
chainchain:1-523
checksum24BA0B36521AC2D4
commentFUNCTION Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity) (PubMed:10863037). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (By similarity). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (By similarity).CATALYTIC ACTIVITY L-alanine(in) + glycine(out) = L-alanine(out) + glycine(in)CATALYTIC ACTIVITY L-serine(out) + L-alanine(in) = L-serine(in) + L-alanine(out)CATALYTIC ACTIVITY L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)CATALYTIC ACTIVITY L-cysteine(out) + L-alanine(in) = L-cysteine(in) + L-alanine(out)CATALYTIC ACTIVITY 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)CATALYTIC ACTIVITY D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)CATALYTIC ACTIVITY D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)CATALYTIC ACTIVITY L-valine(out) + L-alanine(in) = L-valine(in) + L-alanine(out)CATALYTIC ACTIVITY L-methionine(out) + L-alanine(in) = L-methionine(in) + L-alanine(out)CATALYTIC ACTIVITY beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)CATALYTIC ACTIVITY D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)CATALYTIC ACTIVITY D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)CATALYTIC ACTIVITY D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)CATALYTIC ACTIVITY D-serine(in) = D-serine(out)BIOPHYSICOCHEMICAL PROPERTIES Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.INTERACTION Colocalizes with OLIG2 in astrocytic processes. Localizes to the plasma membrane in mature adipocytes and to intracellular structures in preadipocytes.TISSUE SPECIFICITY Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily.
descriptionrecommendedName: Asc-type amino acid transporter 1 shortName: Asc-1 alternativeName: Solute carrier family 7 member 10
geneNameSLC7A10
ASC1
identifierQ9NS82
isSequenceChangedFALSE
keyword3D-structure
Amino-acid transport
Cell membrane
Disulfide bond
Membrane
Proteomics identification
Reference proteome
Transmembrane
Transmembrane helix
Transport
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
nameSLC7A10
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8991105] ENSEMBL:ENSG00000130876 SLC7A10 [Homo sapiens]
secondaryIdentifierAAA1_HUMAN
B2RE84
sequenceLength523
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:376190] SLC7A10 [plasma membrane] [Homo sapiens]
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