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Details on Person UniProt:P29274 ADORA2A
| Class:Id | ReferenceGeneProduct:49356 |
|---|---|
| _chainChangeLog | chain:1-412 added on Fri February 6 2015 |
| _displayName | UniProt:P29274 ADORA2A |
| _timestamp | 2024-11-03 20:08:40 |
| chain | chain:1-412 |
| checksum | 9438E9D64A6BE61B |
| comment | FUNCTION Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).SUBUNIT Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (PubMed:16339847). May interact with DRD4 (PubMed:18832607). Interacts with NECAB2 (PubMed:17689978). Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (By similarity).INTERACTION Colocalizes with GAS2L2 at neuronal processes.DOMAIN The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.PTM Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: Adenosine receptor A2a |
| geneName | ADORA2A ADORA2 |
| identifier | P29274 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ADORA2A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994639] ENSEMBL:ENSG00000128271 ADORA2A [Homo sapiens] |
| secondaryIdentifier | AA2AR_HUMAN B2R7E0 |
| sequenceLength | 412 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:187668] ADORA2A [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:418934] ADORA2A [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P29274 ADORA2A (49356)
